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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB00157
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB00157 NADH Thumb


144 known interactions (targets) of input drug (DB00157): NADH
No. Gene UniProt ID Protein Name Pathway PDB
1 NDUFB10 O96000 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
2 NDUFS4 O43181 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
3 MT-ND1 P03886 NADH-ubiquinone oxidoreductase chain 1 hsa00190; hsa01100; hsa04714; hsa04723; hsa05012 NA
4 NDUFB8 O95169 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
5 HSD3B2 P26439 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 hsa00140; hsa01100; hsa04913; hsa04925; hsa04927; hsa04934 NA
6 NDUFC1 O43677 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
7 MT-ND5 P03915 NADH-ubiquinone oxidoreductase chain 5 hsa00190; hsa01100; hsa04714; hsa04723; hsa05012 NA
8 ALDH4A1 P30038 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial hsa00250; hsa00330; hsa01100 3V9G; 3V9H; 3V9I; 4OE5
9 OGDH Q02218 2-oxoglutarate dehydrogenase, mitochondrial hsa00020; hsa00310; hsa00380; hsa01100; hsa01200 3ERY
10 NDUFA5 Q16718 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
11 ME1 P48163 NADP-dependent malic enzyme hsa00620; hsa01100; hsa01200; hsa03320 2AW5; 3WJA
12 HSD17B4 P51659 Peroxisomal multifunctional enzyme type 2 hsa00120; hsa01100; hsa04146 1IKT; 1S9C; 1ZBQ
13 NDUFV3 P56181 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
14 LDHC P07864 L-lactate dehydrogenase C chain hsa00010; hsa00270; hsa00620; hsa00640; hsa01100; hsa04922 NA
15 HMOX2 P30519 Heme oxygenase 2 hsa00860; hsa01100; hsa04978 2Q32; 2QPP; 2RGZ; 4WMH
16 IDH3G P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial hsa00020; hsa01100; hsa01200; hsa01210; hsa01230 NA
17 AKR1B1 P15121 Aldose reductase hsa00040; hsa00051; hsa00052; hsa00561; hsa00790; hsa01100
1ABN; 1ADS; 1AZ1; 1AZ2; 1EF3; 1EL3; 1IEI; 1MAR; 1PWL; 1PWM; 1T40; 1T41; 1US0; 1X96; 1X97; 1X98; 1XGD; 1Z3N; 1Z89; 1Z8A; 2ACQ; 2ACR; 2ACS; 2ACU; 2AGT; 2DUX; 2DUZ; 2DV0; 2F2K; 2FZ8; 2FZ9; 2FZB; 2FZD; 2HV5; 2HVN; 2HVO; 2I16; 2I17; 2IKG; 2IKH; 2IKI; 2IKJ; 2INE; 2INZ; 2IPW; 2IQ0; 2IQD; 2IS7; 2ISF; 2J8T; 2NVC; 2NVD; 2PD5; 2PD9; 2PDB; 2PDC; 2PDF; 2PDG; 2PDH; 2PDI; 2PDJ; 2PDK; 2PDL; 2PDM; 2PDN; 2PDP; 2PDQ; 2PDU; 2PDW; 2PDX; 2PDY; 2PEV; 2PF8; 2PFH; 2PZN; 2QXW; 2R24; 3BCJ; 3DN5; 3G5E; 3GHR; 3GHS; 3GHT; 3GHU; 3LBO; 3LD5; 3LEN; 3LEP; 3LQG; 3LQL; 3LZ3; 3LZ5; 3M0I; 3M4H; 3M64; 3MB9; 3MC5; 3ONB; 3ONC; 3P2V; 3Q65; 3Q67; 3RX2; 3RX3; 3RX4; 3S3G; 3T42; 3U2C; 3V35; 3V36; 4GCA; 4GQ0; 4IGS; 4JIR; 4LAU; 4LAZ; 4LB3; 4LB4; 4LBR; 4LBS; 4NKC; 4PR4; 4PRR; 4PRT; 4PUU; 4PUW; 4Q7B; 4QBX; 4QR6; 4QX4; 4QXI; 4RPQ; 4XZH; 4XZI
18 MT-ND4 P03905 NADH-ubiquinone oxidoreductase chain 4 hsa00190; hsa01100; hsa04714; hsa04723; hsa05012 NA
19 HIBADH P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial hsa00280; hsa01100 2GF2; 2I9P
20 CYP17A1 P05093 Steroid 17-alpha-hydroxylase/17,20 lyase hsa00140; hsa01100; hsa04913; hsa04917; hsa04927; hsa04934 2C17; 3RUK; 3SWZ; 4NKV; 4NKW; 4NKX; 4NKY; 4NKZ
21 HSD11B2 P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 hsa00140; hsa04960 NA
22 ME3 Q16798 NADP-dependent malic enzyme, mitochondrial hsa00620; hsa01100; hsa01200 NA
23 EHHADH Q08426 Peroxisomal bifunctional enzyme hsa00071; hsa00280; hsa00310; hsa00380; hsa00410; hsa00640; hsa00650; hsa01100; hsa01200; hsa01212; hsa03320; hsa04146 NA
24 ALDH3B1 P43353 Aldehyde dehydrogenase family 3 member B1 hsa00010; hsa00340; hsa00350; hsa00360; hsa00410; hsa00980; hsa00982; hsa01100; hsa05204 NA
25 MTHFD1 P11586 C-1-tetrahydrofolate synthase, cytoplasmic hsa00670; hsa01100 1A4I; 1DIA; 1DIB; 1DIG
26 ALDH1B1 P30837 Aldehyde dehydrogenase X, mitochondrial hsa00010; hsa00053; hsa00071; hsa00280; hsa00310; hsa00330; hsa00340; hsa00380; hsa00410; hsa00561; hsa00620; hsa01100 NA
27 ALDH5A1 P51649 Succinate-semialdehyde dehydrogenase, mitochondrial hsa00250; hsa00650; hsa01100 2W8N; 2W8O; 2W8P; 2W8Q; 2W8R
28 NDUFA2 O43678 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 1S3A
29 AKR1C2 P52895 Aldo-keto reductase family 1 member C2 hsa00140; hsa05204 1IHI; 1J96; 1XJB; 2HDJ; 2IPJ; 4JQ1; 4JQ2; 4JQ3; 4JQ4; 4JQA; 4JTQ; 4JTR; 4L1W; 4L1X
30 ADH7 P40394 Alcohol dehydrogenase class 4 mu/sigma chain hsa00010; hsa00071; hsa00350; hsa00830; hsa00980; hsa00982; hsa01100; hsa05204 1AGN; 1D1S; 1D1T
31 NDUFS3 O75489 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
32 MT-ND2 P03891 NADH-ubiquinone oxidoreductase chain 2 hsa00190; hsa01100; hsa04714; hsa04723; hsa05012 NA
33 MSMO1 Q15800 Methylsterol monooxygenase 1 hsa00100; hsa01100 NA
34 HSD17B10 Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 hsa00280; hsa01100; hsa05010 1F67; 1SO8; 1U7T; 2O23
35 AASS Q9UDR5 Alpha-aminoadipic semialdehyde synthase, mitochondrial hsa00310; hsa01100 NA
36 IMPDH2 P12268 Inosine-5'-monophosphate dehydrogenase 2 hsa00230; hsa00983; hsa01100 1B3O; 1NF7; 1NFB
37 HSD17B1 P14061 Estradiol 17-beta-dehydrogenase 1 hsa00140; hsa01100; hsa04913
38 H6PD O95479 GDH/6PGL endoplasmic bifunctional protein hsa00030; hsa01100; hsa01200 NA
39 HADHA P40939 Trifunctional enzyme subunit alpha, mitochondrial hsa00062; hsa00071; hsa00280; hsa00310; hsa00380; hsa00410; hsa00640; hsa00650; hsa01040; hsa01100; hsa01200; hsa01212 NA
40 ALDH2 P05091 Aldehyde dehydrogenase, mitochondrial hsa00010; hsa00053; hsa00071; hsa00280; hsa00310; hsa00330; hsa00340; hsa00380; hsa00410; hsa00561; hsa00620; hsa01100
41 DHFR P00374 Dihydrofolate reductase hsa00670; hsa00790; hsa01100; hsa01523
42 MDH1 P40925 Malate dehydrogenase, cytoplasmic hsa00020; hsa00270; hsa00620; hsa00630; hsa01100; hsa01200; hsa04964 NA
43 ADH4 P08319 Alcohol dehydrogenase 4 hsa00010; hsa00071; hsa00350; hsa00830; hsa00980; hsa00982; hsa01100; hsa05204 3COS
44 DHCR7 Q9UBM7 7-dehydrocholesterol reductase hsa00100; hsa01100 NA
45 HSD17B2 P37059 Estradiol 17-beta-dehydrogenase 2 hsa00140; hsa01100; hsa04913 NA
46 HPGD P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] hsa05202 2GDZ
47 NDUFA13 Q9P0J0 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
48 ALDH1A3 P47895 Aldehyde dehydrogenase family 1 member A3 hsa00010; hsa00340; hsa00350; hsa00360; hsa00410; hsa00980; hsa00982; hsa01100; hsa05204 NA
49 ALDH3B2 P48448 Aldehyde dehydrogenase family 3 member B2 NA NA
50 PDHB P11177 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial hsa00010; hsa00020; hsa00620; hsa01100; hsa01200; hsa04066; hsa04922; hsa05230 1NI4; 2OZL; 3EXE; 3EXF; 3EXG; 3EXH; 3EXI
51 SORD Q00796 Sorbitol dehydrogenase hsa00040; hsa00051; hsa01100 1PL6; 1PL7; 1PL8
52 IMPDH1 P20839 Inosine-5'-monophosphate dehydrogenase 1 hsa00230; hsa00983; hsa01100 1JCN
53 NQO2 P16083 Ribosyldihydronicotinamide dehydrogenase [quinone] NA
54 NDUFB9 Q9Y6M9 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
55 CDO1 Q16878 Cysteine dioxygenase type 1 hsa00270; hsa00430; hsa01100 2IC1
56 HSD11B1 P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 hsa00140; hsa00980; hsa01100; hsa05204
57 MT-ND3 P03897 NADH-ubiquinone oxidoreductase chain 3 hsa00190; hsa01100; hsa04714; hsa04723; hsa05012 NA
58 ALDH7A1 P49419 Alpha-aminoadipic semialdehyde dehydrogenase hsa00010; hsa00053; hsa00071; hsa00260; hsa00280; hsa00310; hsa00330; hsa00340; hsa00380; hsa00410; hsa00561; hsa00620; hsa01100 2J6L; 4X0T; 4X0U; 4ZUK; 4ZUL; 4ZVW; 4ZVX; 4ZVY
59 AKR1C3 P42330 Aldo-keto reductase family 1 member C3 hsa00140; hsa00590; hsa00790; hsa01100; hsa04913
60 NDUFS2 O75306 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
61 LDHA P00338 L-lactate dehydrogenase A chain hsa00010; hsa00270; hsa00620; hsa00640; hsa01100; hsa04066; hsa04922; hsa05230 1I10; 4AJP; 4JNK; 4L4R; 4L4S; 4M49; 4OJN; 4OKN; 4QO7; 4QO8; 4QSM; 4QT0; 4R68; 4R69; 4RLS
62 NNT Q13423 NAD(P) transhydrogenase, mitochondrial hsa00760; hsa01100 1DJL; 1PT9; 1U31
63 NSDHL Q15738 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating hsa00100; hsa01100 NA
64 ALDH1A1 P00352 Retinal dehydrogenase 1 hsa00830; hsa01100 4WB9; 4WJ9; 4WP7; 4WPN; 4X4L; 5AC2
65 NDUFA7 O95182 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
66 LDHAL6B Q9BYZ2 L-lactate dehydrogenase A-like 6B hsa00010; hsa00270; hsa00620; hsa00640; hsa01100; hsa04922 NA
67 PDHA1 P08559 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial hsa00010; hsa00020; hsa00620; hsa01100; hsa01200; hsa04066; hsa04922; hsa05230 1NI4; 2OZL; 3EXE; 3EXF; 3EXG; 3EXH; 3EXI
68 HSD17B3 P37058 Testosterone 17-beta-dehydrogenase 3 hsa00140; hsa01100 NA
69 BLVRB P30043 Flavin reductase (NADPH) hsa00740; hsa00860; hsa01100 1HDO; 1HE2; 1HE3; 1HE4; 1HE5
70 NDUFS1 P28331 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
71 ADH1B P00325 Alcohol dehydrogenase 1B hsa00010; hsa00071; hsa00350; hsa00830; hsa00980; hsa00982; hsa01100; hsa05204 1DEH; 1HDX; 1HDY; 1HDZ; 1HSZ; 1HTB; 1U3U; 1U3V; 3HUD
72 MTHFD2 P13995 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial hsa00670; hsa01100 1ZN4
73 ADH1C P00326 Alcohol dehydrogenase 1C hsa00010; hsa00071; hsa00350; hsa00830; hsa00980; hsa00982; hsa01100; hsa05204 1DDA; 1HT0; 1U3W
74 NDUFB6 O95139 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
75 NDUFB2 O95178 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
76 ACADS P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial hsa00071; hsa00280; hsa00650; hsa01100; hsa01200; hsa01212 2VIG
77 PDHA2 P29803 Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial hsa00010; hsa00020; hsa00620; hsa01100; hsa01200; hsa04066; hsa04922; hsa05230 NA
78 RDH5 Q92781 11-cis retinol dehydrogenase hsa00830 NA
79 GLUD1 P00367 Glutamate dehydrogenase 1, mitochondrial hsa00220; hsa00250; hsa00471; hsa00910; hsa01100; hsa01200; hsa04217; hsa04964 1L1F; 1NR1
80 QDPR P09417 Dihydropteridine reductase hsa00790; hsa01100 1HDR
81 NDUFA9 Q16795 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
82 IDH3A P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial hsa00020; hsa01100; hsa01200; hsa01210; hsa01230 NA
83 GPD1 P21695 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic hsa00564 1WPQ; 1X0V; 1X0X
84 NDUFS5 O43920 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
85 AKR1C4 P17516 Aldo-keto reductase family 1 member C4 hsa00120; hsa00140; hsa01100 2FVL
86 HSD3B1 P14060 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 hsa00140; hsa01100; hsa04913; hsa04925; hsa04927; hsa04934 NA
87 TYR P14679 Tyrosinase hsa00350; hsa01100; hsa04916 NA
88 NDUFB3 O43676 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
89 ALDH1A2 O94788 Retinal dehydrogenase 2 hsa00830; hsa01100 NA
90 UGDH O60701 UDP-glucose 6-dehydrogenase hsa00040; hsa00053; hsa00520; hsa01100 2Q3E; 2QG4; 3ITK; 3KHU; 3PRJ; 3PTZ; 3TDK; 3TF5; 4EDF; 4QEJ; 4RJT
91 NDUFA3 O95167 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
92 GAPDH P04406 Glyceraldehyde-3-phosphate dehydrogenase hsa00010; hsa01100; hsa01200; hsa01230; hsa04066; hsa05010 1U8F; 1ZNQ; 2FEH; 3GPD; 4WNC; 4WNI
93 NDUFS7 O75251 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
94 DLAT P10515 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial hsa00010; hsa00020; hsa00620; hsa01100; hsa01200 1FYC; 1Y8N; 1Y8O; 1Y8P; 2DNE; 2PNR; 2Q8I; 3B8K; 3CRK; 3CRL
95 NDUFA4L2 Q9NRX3 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
96 MT-ND6 P03923 NADH-ubiquinone oxidoreductase chain 6 hsa00190; hsa01100; hsa04714; hsa04723; hsa05012 NA
97 NDUFA6 P56556 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
98 HADH Q16836 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial hsa00062; hsa00071; hsa00280; hsa00310; hsa00380; hsa00650; hsa01100; hsa01212 1F0Y; 1F12; 1F14; 1F17; 1IL0; 1LSJ; 1LSO; 1M75; 1M76; 2HDH; 3HAD; 3RQS
99 NDUFA1 O15239 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
100 NDUFB7 P17568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
101 NDUFA11 Q86Y39 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
102 HMGCR P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase hsa00900; hsa01100; hsa04152; hsa04976
103 HSD17B7 P56937 3-keto-steroid reductase hsa00100; hsa00140; hsa01100; hsa04913 NA
104 NDUFS8 O00217 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
105 NDUFAB1 O14561 Acyl carrier protein, mitochondrial hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 2DNW
106 PHGDH O43175 D-3-phosphoglycerate dehydrogenase hsa00260; hsa01100; hsa01200; hsa01230 2G76
107 IDH3B O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial hsa00020; hsa01100; hsa01200; hsa01210; hsa01230 NA
108 MDH2 P40926 Malate dehydrogenase, mitochondrial hsa00020; hsa00270; hsa00620; hsa00630; hsa01100; hsa01200 2DFD
109 NDUFS6 O75380 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
110 AKR1C1 Q04828 Aldo-keto reductase family 1 member C1 hsa00140; hsa00980 1MRQ; 3C3U; 3GUG; 3NTY
111 ADH1A P07327 Alcohol dehydrogenase 1A hsa00010; hsa00071; hsa00350; hsa00830; hsa00980; hsa00982; hsa01100; hsa05204 1HSO; 1U3T
112 NDUFV2 P19404 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
113 NDUFV1 P49821 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
114 ME2 P23368 NAD-dependent malic enzyme, mitochondrial hsa00620; hsa01200 1DO8; 1EFK; 1EFL; 1GZ3; 1GZ4; 1PJ2; 1PJ3; 1PJ4; 1PJL; 1QR6
115 CYB5R3 P00387 NADH-cytochrome b5 reductase 3 hsa00520 1M91; 1UMK
116 AMT P48728 Aminomethyltransferase, mitochondrial hsa00260; hsa00630; hsa00670; hsa01100; hsa01200 1WSR; 1WSV
117 GLUD2 P49448 Glutamate dehydrogenase 2, mitochondrial hsa00220; hsa00250; hsa00471; hsa00910; hsa01100; hsa01200; hsa04217; hsa04964 NA
118 ALDH3A1 P30838 Aldehyde dehydrogenase, dimeric NADP-preferring hsa00010; hsa00340; hsa00350; hsa00360; hsa00410; hsa00980; hsa00982; hsa01100; hsa05204 3SZA; 3SZB; 4H80; 4L1O; 4L2O
119 NDUFC2 O95298 NADH dehydrogenase [ubiquinone] 1 subunit C2 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
120 PYCR1 P32322 Pyrroline-5-carboxylate reductase 1, mitochondrial hsa00330; hsa01100; hsa01230 2GER; 2GR9; 2GRA; 2IZZ
121 PYCR2 Q96C36 Pyrroline-5-carboxylate reductase 2 hsa00330; hsa01100; hsa01230 NA
122 NDUFB4 O95168 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
123 ALDH9A1 P49189 4-trimethylaminobutyraldehyde dehydrogenase hsa00010; hsa00053; hsa00071; hsa00280; hsa00310; hsa00330; hsa00340; hsa00380; hsa00410; hsa00561; hsa00620; hsa01100 NA
124 NDUFB1 O75438 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
125 ADH5 P11766 Alcohol dehydrogenase class-3 hsa00010; hsa00071; hsa00350; hsa00830; hsa00980; hsa00982; hsa01100; hsa01200; hsa05204 1M6H; 1M6W; 1MA0; 1MC5; 1MP0; 1TEH; 2FZE; 2FZW; 3QJ5
126 NDUFA12 Q9UI09 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
127 LDHB P07195 L-lactate dehydrogenase B chain hsa00010; hsa00270; hsa00620; hsa00640; hsa01100; hsa04922 1I0Z; 1T2F
128 BDH1 Q02338 D-beta-hydroxybutyrate dehydrogenase, mitochondrial hsa00072; hsa00650; hsa01100 NA
129 NDUFA10 O95299 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
130 LDHAL6A Q6ZMR3 L-lactate dehydrogenase A-like 6A hsa00010; hsa00270; hsa00620; hsa00640; hsa01100; hsa04922 NA
131 NDUFA8 P51970 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
132 ALDH6A1 Q02252 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial hsa00280; hsa00410; hsa00562; hsa00640; hsa01100; hsa01200 NA
133 HMOX1 P09601 Heme oxygenase 1 hsa00860; hsa01100; hsa04066; hsa04216; hsa04978; hsa05200; hsa05206; hsa05225; hsa05418
134 NDUFB5 O43674 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
135 ALDH3A2 P51648 Fatty aldehyde dehydrogenase hsa00010; hsa00053; hsa00071; hsa00280; hsa00310; hsa00330; hsa00340; hsa00380; hsa00410; hsa00561; hsa00620; hsa01100 4QGK
136 CYP4A11 Q02928 Cytochrome P450 4A11 hsa00071; hsa00590; hsa00830; hsa01100; hsa03320; hsa04270; hsa04750 NA
137 MT-ND4L P03901 NADH-ubiquinone oxidoreductase chain 4L hsa00190; hsa01100; hsa04714; hsa04723; hsa05012 NA
138 GAPDHS O14556 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific hsa00010; hsa01100 3H9E; 3PFW
139 TSTA3 Q13630 GDP-L-fucose synthase hsa00051; hsa00520; hsa01100 4B8W; 4B8Z; 4BKP; 4BL5; 4E5Y
140 BLVRA P53004 Biliverdin reductase A hsa00860; hsa01100 2H63
141 GSR P00390 Glutathione reductase, mitochondrial hsa00480; hsa04918
142 HSD17B8 Q92506 Estradiol 17-beta-dehydrogenase 8 hsa00140; hsa01100 2PD6; 4CQL; 4CQM
143 NDUFA4 O00483 Cytochrome c oxidase subunit NDUFA4 hsa00190; hsa01100; hsa04714; hsa04723; hsa04932; hsa05010; hsa05012; hsa05016 NA
144 DLD P09622 Dihydrolipoyl dehydrogenase, mitochondrial hsa00010; hsa00020; hsa00260; hsa00280; hsa00620; hsa00630; hsa00640; hsa01100; hsa01200 1ZMC; 1ZMD; 1ZY8; 2F5Z; 3RNM


20 predicted interactions (targets) of input drug (DB00157): NADH
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 ACE P12821 Angiotensin-converting enzyme hsa04614; hsa04924; hsa05142; hsa05410 61.7%
2 AR P10275 Androgen receptor hsa04114; hsa05200; hsa05215 53.9%
3 CHEK1 O14757 Serine/threonine-protein kinase Chk1 hsa04110; hsa04115; hsa04218; hsa05166; hsa05170; hsa05203 51.9%
4 YARS P54577 Tyrosine--tRNA ligase, cytoplasmic hsa00970 1N3L; 1NTG; 1Q11; 4Q93; 4QBT 51.5%
5 DDC P20711 Aromatic-L-amino-acid decarboxylase hsa00350; hsa00360; hsa00380; hsa01100; hsa04726; hsa04728; hsa05030; hsa05031; hsa05034 3RBF; 3RBL; 3RCH 50.5%
6 SHMT2 P34897 Serine hydroxymethyltransferase, mitochondrial hsa00260; hsa00630; hsa00670; hsa01100; hsa01200; hsa01230; hsa01523 3OU5; 4PVF 46.8%
7 LYZ P61626 Lysozyme C hsa04970
133L; 134L; 1B5U; 1B5V; 1B5W; 1B5X; 1B5Y; 1B5Z; 1B7L; 1B7M; 1B7N; 1B7O; 1B7P; 1B7Q; 1B7R; 1B7S; 1BB3; 1BB4; 1BB5; 1C43; 1C45; 1C46; 1C7P; 1CJ6; 1CJ7; 1CJ8; 1CJ9; 1CKC; 1CKD; 1CKF; 1CKG; 1CKH; 1D6P; 1D6Q; 1DI3; 1DI4; 1DI5; 1EQ4; 1EQ5; 1EQE; 1GAY; 1GAZ; 1GB0; 1GB2; 1GB3; 1GB5; 1GB6; 1GB7; 1GB8; 1GB9; 1GBO; 1GBW; 1GBX; 1GBY; 1GBZ; 1GDW; 1GDX; 1GE0; 1GE1; 1GE2; 1GE3; 1GE4; 1GEV; 1GEZ; 1GF0; 1GF3; 1GF4; 1GF5; 1GF6; 1GF7; 1GF8; 1GF9; 1GFA; 1GFE; 1GFG; 1GFH; 1GFJ; 1GFK; 1GFR; 1GFT; 1GFU; 1GFV; 1HNL; 1I1Z; 1I20; 1I22; 1INU; 1IOC; 1IP1; 1IP2; 1IP3; 1IP4; 1IP5; 1IP6; 1IP7; 1IWT; 1IWU; 1IWV; 1IWW; 1IWX; 1IWY; 1IWZ; 1IX0; 1IY3; 1IY4; 1JKA; 1JKB; 1JKC; 1JKD; 1JSF; 1JWR; 1LAA; 1LHH; 1LHI; 1LHJ; 1LHK; 1LHL; 1LHM; 1LMT; 1LOZ; 1LYY; 1LZ1; 1LZ4; 1LZ5; 1LZ6; 1LZR; 1LZS; 1OP9; 1OUA; 1OUB; 1OUC; 1OUD; 1OUE; 1OUF; 1OUG; 1OUH; 1OUI; 1OUJ; 1QSW; 1RE2; 1REM; 1REX; 1REY; 1REZ; 1TAY; 1TBY; 1TCY; 1TDY; 1UBZ; 1W08; 1WQM; 1WQN; 1WQO; 1WQP; 1WQQ; 1WQR; 1YAM; 1YAN; 1YAO; 1YAP; 1YAQ; 207L; 208L; 2BQA; 2BQB; 2BQC; 2BQD; 2BQE; 2BQF; 2BQG; 2BQH; 2BQI; 2BQJ; 2BQK; 2BQL; 2BQM; 2BQN; 2BQO; 2HEA; 2HEB; 2HEC; 2HED; 2HEE; 2HEF; 2LHM; 2MEA; 2MEB; 2MEC; 2MED; 2MEE; 2MEF; 2MEG; 2MEH; 2MEI; 2NWD; 2ZIJ; 2ZIK; 2ZIL; 2ZWB; 3EBA; 3FE0; 3LHM; 3LN2; 4I0C; 4ML7; 4R0P
 46.4%
8 VKORC1 Q9BQB6 Vitamin K epoxide reductase complex subunit 1 hsa00130 NA 46.3%
9 AGTR1 P30556 Type-1 angiotensin II receptor hsa04020; hsa04022; hsa04072; hsa04080; hsa04261; hsa04270; hsa04371; hsa04614; hsa04924; hsa04925; hsa04927; hsa04933; hsa04934; hsa05200 1ZV0; 4YAY; 4ZUD 43.8%
10 PPIA P62937 Peptidyl-prolyl cis-trans isomerase A hsa04217 43.3%
11 IDH1 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic hsa00020; hsa00480; hsa01100; hsa01200; hsa01210; hsa01230; hsa04146; hsa05230 1T09; 1T0L; 3INM; 3MAP; 3MAR; 3MAS; 4I3K; 4I3L; 4KZO; 4L03; 4L04; 4L06; 4UMX; 4UMY; 5DE1 43.2%
12 FDXR P22570 NADPH:adrenodoxin oxidoreductase, mitochondrial NA NA 43.1%
13 POR P16435 NADPH--cytochrome P450 reductase NA 1B1C; 3FJO; 3QE2; 3QFC; 3QFR; 3QFS; 3QFT 42.1%
14 PARP1 P09874 Poly [ADP-ribose] polymerase 1 hsa03410; hsa04064; hsa04210; hsa04217 42.1%
15 HNRNPK P61978 Heterogeneous nuclear ribonucleoprotein K hsa03040; hsa05168; hsa05203; hsa05206 1J5K; 1KHM; 1ZZI; 1ZZJ; 1ZZK 41.8%
16 TOP2A P11388 DNA topoisomerase 2-alpha hsa01524 1LWZ; 1ZXM; 1ZXN; 4FM9; 4R1F 41.1%
17 MMP8 P22894 Neutrophil collagenase NA 41.0%
18 AURKA O14965 Aurora kinase A hsa04114; hsa04914 40.6%
19 TF P02787 Serotransferrin hsa04066; hsa04216; hsa04978 40.6%
20 ICAM1 P05362 Intercellular adhesion molecule 1 hsa04064; hsa04514; hsa04650; hsa04668; hsa04670; hsa04933; hsa05143; hsa05144; hsa05150; hsa05164; hsa05166; hsa05167; hsa05169; hsa05323; hsa05416; hsa05418 1D3E; 1D3I; 1D3L; 1IAM; 1IC1; 1IJ4; 1MQ8; 1P53; 1Z7Z; 2OZ4; 3TCX 39.1%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.