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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB01593
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb


124 known interactions (targets) of input drug (DB01593): Zinc
No. Gene UniProt ID Protein Name Pathway PDB
1 DSP P15924 Desmoplakin hsa05412 1LM5; 1LM7; 3R6N; 5DZZ
2 APCS P02743 Serum amyloid P-component NA 1GYK; 1LGN; 1SAC; 2A3W; 2A3X; 2A3Y; 2W08; 3D5O; 3KQR; 4AVS; 4AVT; 4AVV; 4AYU
3 HRNR Q86YZ3 Hornerin NA NA
4 TP73 O15350 Tumor protein p73 hsa04115; hsa04390; hsa04722; hsa05162
5 PSPH P78330 Phosphoserine phosphatase hsa00260; hsa01100; hsa01200; hsa01230 1L8L; 1L8O; 1NNL
6 NA P01619 Ig kappa chain V-III region GOL NA NA
7 CFI P05156 Complement factor I hsa04610; hsa05150 2XRC
8 CFB P00751 Complement factor B hsa04610; hsa05150 1DLE; 1Q0P; 1RRK; 1RS0; 1RTK; 2OK5; 2WIN; 2XWB; 2XWJ; 3HRZ; 3HS0
9 GSN P06396 Gelsolin hsa04666; hsa04810; hsa05203
10 HPR P00739 Haptoglobin-related protein hsa05143 NA
11 PARP1 P09874 Poly [ADP-ribose] polymerase 1 hsa03410; hsa04064; hsa04210; hsa04217
12 FCN3 O75636 Ficolin-3 NA 1LA5; 2J5Z; 2J60; 2J64
13 KLKB1 P03952 Plasma kallikrein hsa04610 2ANW; 2ANY; 4OGX; 4OGY; 4ZJ4; 4ZJ5; 4ZJ6
14 KRT16 P08779 Keratin, type I cytoskeletal 16 hsa04915 NA
15 KRT2 P35908 Keratin, type II cytoskeletal 2 epidermal NA NA
16 MMP9 P14780 Matrix metalloproteinase-9 hsa01522; hsa04657; hsa04668; hsa04670; hsa04915; hsa04926; hsa05161; hsa05200; hsa05202; hsa05205; hsa05206; hsa05215; hsa05219; hsa05418 1GKC; 1GKD; 1ITV; 1L6J; 1LKG; 2OVX; 2OVZ; 2OW0; 2OW1; 2OW2; 4H1Q; 4H2E; 4H3X; 4H82; 4HMA; 4JIJ; 4JQG; 4WZV; 4XCT
17 PZP P20742 Pregnancy zone protein NA NA
18 C1S P09871 Complement C1s subcomponent hsa04610; hsa05133; hsa05150; hsa05322 1ELV; 1NZI; 4J1Y; 4LMF; 4LOR; 4LOS; 4LOT
19 APOE P02649 Apolipoprotein E hsa04979; hsa05010 1B68; 1BZ4; 1EA8; 1GS9; 1H7I; 1LE2; 1LE4; 1LPE; 1NFN; 1NFO; 1OEF; 1OEG; 1OR2; 1OR3; 2KC3; 2KNY; 2L7B
20 C3 P01024 Complement C3 hsa04145; hsa04610; hsa05133; hsa05134; hsa05140; hsa05142; hsa05150; hsa05152; hsa05167; hsa05168; hsa05203; hsa05322
21 FN1 P02751 Fibronectin hsa04151; hsa04510; hsa04512; hsa04810; hsa04933; hsa05100; hsa05146; hsa05165; hsa05200; hsa05205; hsa05222
22 S100A7 P31151 Protein S100-A7 hsa04657 1PSR; 2PSR; 2WND; 2WOR; 2WOS; 3PSR; 4AQJ
23 KRT10 P13645 Keratin, type I cytoskeletal 10 hsa04915; hsa05150 3ASW; 4F1Z; 4ZRY
24 CCS O14618 Copper chaperone for superoxide dismutase hsa05014 1DO5; 2CRL; 2RSQ
25 KRT6A P02538 Keratin, type II cytoskeletal 6A NA 5KI0
26 SEPP1 P49908 Selenoprotein P NA NA
27 INS P01308 Insulin hsa04010; hsa04014; hsa04015; hsa04022; hsa04066; hsa04068; hsa04072; hsa04114; hsa04140; hsa04150; hsa04151; hsa04152; hsa04211; hsa04213; hsa04810; hsa04910; hsa04911; hsa04913; hsa04914; hsa04917; hsa04923; hsa04930; hsa04931; hsa04932; hsa04940; hsa04950; hsa04960; hsa05215
1A7F; 1AI0; 1AIY; 1B9E; 1BEN; 1EFE; 1EV3; 1EV6; 1EVR; 1FU2; 1FUB; 1G7A; 1G7B; 1GUJ; 1HIQ; 1HIS; 1HIT; 1HLS; 1HTV; 1HUI; 1IOG; 1IOH; 1J73; 1JCA; 1JCO; 1JK8; 1K3M; 1KMF; 1LKQ; 1LPH; 1MHI; 1MHJ; 1MSO; 1OS3; 1OS4; 1Q4V; 1QIY; 1QIZ; 1QJ0; 1RWE; 1SF1; 1SJT; 1SJU; 1T0C; 1T1K; 1T1P; 1T1Q; 1TRZ; 1TYL; 1TYM; 1UZ9; 1VKT; 1W8P; 1XDA; 1XGL; 1XW7; 1ZEG; 1ZEH; 1ZNJ; 2AIY; 2C8Q; 2C8R; 2CEU; 2G54; 2G56; 2H67; 2HH4; 2HHO; 2HIU; 2JMN; 2JUM; 2JUU; 2JUV; 2JV1; 2JZQ; 2K91; 2K9R; 2KJJ; 2KJU; 2KQP; 2KQQ; 2KXK; 2L1Y; 2L1Z; 2LGB; 2LWZ; 2M1D; 2M1E; 2M2M; 2M2N; 2M2O; 2M2P; 2MLI; 2MPG; 2MPI; 2MVC; 2MVD; 2OLY; 2OLZ; 2OM0; 2OM1; 2OMG; 2OMH; 2OMI; 2OMQ; 2QIU; 2R34; 2R35; 2R36; 2RN5; 2VJZ; 2VK0; 2W44; 2WBY; 2WC0; 2WRU; 2WRV; 2WRW; 2WRX; 2WS0; 2WS1; 2WS4; 2WS6; 2WS7; 3AIY; 3BXQ; 3E7Y; 3E7Z; 3EXX; 3FQ9; 3HYD; 3I3Z; 3I40; 3ILG; 3INC; 3IR0; 3JSD; 3KQ6; 3P2X; 3P33; 3Q6E; 3ROV; 3TT8; 3U4N; 3UTQ; 3UTS; 3UTT; 3V19; 3V1G; 3W11; 3W12; 3W13; 3W7Y; 3W7Z; 3W80; 3ZI3; 3ZQR; 3ZS2; 3ZU1; 4AIY; 4AJX; 4AJZ; 4AK0; 4AKJ; 4CXL; 4CXN; 4CY7; 4EFX; 4EWW; 4EWX; 4EWZ; 4EX0; 4EX1; 4EXX; 4EY1; 4EY9; 4EYD; 4EYN; 4EYP; 4F0N; 4F0O; 4F1A; 4F1B; 4F1C; 4F1D; 4F1F; 4F1G; 4F4T; 4F4V; 4F51; 4F8F; 4FG3; 4FKA; 4GBC; 4GBI; 4GBK; 4GBL; 4GBN; 4IUZ; 4IYD; 4IYF; 4NIB; 4OGA; 4P65; 4Q5Z; 4RXW; 4UNE; 4UNG; 4UNH; 4WDI; 4XC4; 4Y19; 4Y1A; 4Z76; 4Z77; 4Z78; 5AIY; 5CNY; 5CO2; 5CO6; 5CO9
28 IGFALS P35858 Insulin-like growth factor-binding protein complex acid labile subunit NA NA
29 UTRN P46939 Utrophin NA 1BHD; 1QAG
30 PGLYRP2 Q96PD5 N-acetylmuramoyl-L-alanine amidase NA NA
31 TP53 P04637 Cellular tumor antigen p53 hsa01522; hsa01524; hsa04010; hsa04071; hsa04110; hsa04115; hsa04137; hsa04151; hsa04210; hsa04211; hsa04216; hsa04218; hsa04310; hsa04722; hsa04919; hsa05014; hsa05016; hsa05160; hsa05161; hsa05162; hsa05163; hsa05165; hsa05166; hsa05167; hsa05168; hsa05169; hsa05200; hsa05202; hsa05203; hsa05205; hsa05206; hsa05210; hsa05212; hsa05213; hsa05214; hsa05215; hsa05216; hsa05217; hsa05218; hsa05219; hsa05220; hsa05222; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05418
32 C1R P00736 Complement C1r subcomponent hsa04145; hsa04610; hsa05133; hsa05150; hsa05322 1APQ; 1GPZ; 1MD7; 1MD8; 2QY0
33 HBA1 P69905 Hemoglobin subunit alpha NA
1A00; 1A01; 1A0U; 1A0Z; 1A3N; 1A3O; 1A9W; 1ABW; 1ABY; 1AJ9; 1B86; 1BAB; 1BBB; 1BIJ; 1BUW; 1BZ0; 1BZ1; 1BZZ; 1C7B; 1C7C; 1C7D; 1CLS; 1CMY; 1COH; 1DKE; 1DXT; 1DXU; 1DXV; 1FDH; 1FN3; 1G9V; 1GBU; 1GBV; 1GLI; 1GZX; 1HAB; 1HAC; 1HBA; 1HBB; 1HBS; 1HCO; 1HDB; 1HGA; 1HGB; 1HGC; 1HHO; 1IRD; 1J3Y; 1J3Z; 1J40; 1J41; 1J7S; 1J7W; 1J7Y; 1JY7; 1K0Y; 1K1K; 1KD2; 1LFL; 1LFQ; 1LFT; 1LFV; 1LFY; 1LFZ; 1LJW; 1M9P; 1MKO; 1NEJ; 1NIH; 1NQP; 1O1I; 1O1J; 1O1K; 1O1L; 1O1M; 1O1N; 1O1O; 1O1P; 1QI8; 1QSH; 1QSI; 1QXD; 1QXE; 1R1X; 1R1Y; 1RPS; 1RQ3; 1RQ4; 1RQA; 1RVW; 1SDK; 1SDL; 1SHR; 1SI4; 1THB; 1UIW; 1VWT; 1XXT; 1XY0; 1XYE; 1XZ2; 1XZ4; 1XZ5; 1XZ7; 1XZU; 1XZV; 1Y01; 1Y09; 1Y0A; 1Y0C; 1Y0D; 1Y0T; 1Y0W; 1Y22; 1Y2Z; 1Y31; 1Y35; 1Y45; 1Y46; 1Y4B; 1Y4F; 1Y4G; 1Y4P; 1Y4Q; 1Y4R; 1Y4V; 1Y5F; 1Y5J; 1Y5K; 1Y7C; 1Y7D; 1Y7G; 1Y7Z; 1Y83; 1Y85; 1Y8W; 1YDZ; 1YE0; 1YE1; 1YE2; 1YEN; 1YEO; 1YEQ; 1YEU; 1YEV; 1YFF; 1YG5; 1YGD; 1YGF; 1YH9; 1YHE; 1YHR; 1YIE; 1YIH; 1YVQ; 1YVT; 1YZI; 1Z8U; 2D5Z; 2D60; 2DN1; 2DN2; 2DN3; 2DXM; 2H35; 2HBC; 2HBD; 2HBE; 2HBF; 2HBS; 2HCO; 2HHB; 2HHD; 2HHE; 2M6Z; 2W6V; 2W72; 2YRS; 3B75; 3D17; 3D7O; 3DUT; 3HHB; 3HXN; 3IA3; 3IC0; 3IC2; 3KMF; 3NL7; 3NMM; 3ODQ; 3ONZ; 3OO4; 3OO5; 3OVU; 3P5Q; 3QJB; 3QJC; 3QJD; 3QJE; 3R5I; 3S48; 3S65; 3S66; 3SZK; 3WCP; 3WHM; 4FC3; 4HHB; 4IJ2; 4L7Y; 4M4A; 4M4B; 4MQC; 4MQG; 4MQH; 4MQI; 4MQJ; 4MQK; 4N7N; 4N7O; 4N7P; 4N8T; 4NI0; 4NI1; 4ROL; 4ROM; 4WJG; 4X0I; 4X0L; 4XS0; 5E29; 5E6E; 5EE4; 6HBW
34 KRT5 P13647 Keratin, type II cytoskeletal 5 NA 3TNU
35 PON1 P27169 Serum paraoxonase/arylesterase 1 NA 1V04; 1XHR
36 KRT9 P35527 Keratin, type I cytoskeletal 9 hsa04915 NA
37 C8G P07360 Complement component C8 gamma chain hsa04610; hsa05020; hsa05146; hsa05322 1IW2; 1LF7; 2OVA; 2OVD; 2OVE; 2QOS; 2RD7; 3OJY
38 SIVA1 O15304 Apoptosis regulatory protein Siva hsa04115 NA
39 SERPINA4 P29622 Kallistatin NA NA
40 APLP2 Q06481 Amyloid-like protein 2 NA 5JBT
41 ITIH2 P19823 Inter-alpha-trypsin inhibitor heavy chain H2 NA NA
42 APOBR Q0VD83 Apolipoprotein B receptor NA NA
43 C1QB P02746 Complement C1q subcomponent subunit B hsa04610; hsa05020; hsa05133; hsa05142; hsa05150; hsa05322 1PK6; 2JG8; 2JG9; 2WNU; 2WNV
44 A1BG P04217 Alpha-1B-glycoprotein NA NA
45 TUFM P49411 Elongation factor Tu, mitochondrial NA NA
46 S100A8 P05109 Protein S100-A8 hsa04657 1MR8; 1XK4; 4GGF; 4XJK; 5HLO; 5HLV
47 DAND5 Q8N907 DAN domain family member 5 NA NA
48 MT3 P25713 Metallothionein-3 NA 2F5H; 2FJ4; 2FJ5
49 APLP1 P51693 Amyloid-like protein 1 NA 3PMR; 3Q7G; 3Q7L; 3QMK; 4RD9; 4RDA
50 PRDX1 Q06830 Peroxiredoxin-1 hsa04146 2RII; 3HY2
51 APOL1 O14791 Apolipoprotein L1 hsa05143 NA
52 IGLV3-21 P80748 Immunoglobulin lambda variable 3-21 NA 2LOI
53 APP P05067 Amyloid beta A4 protein hsa04726; hsa05010
54 FGA P02671 Fibrinogen alpha chain hsa04610; hsa04611
55 CPN2 P22792 Carboxypeptidase N subunit 2 NA NA
56 APOA4 P06727 Apolipoprotein A-IV NA 3S84
57 GLRA1 P23415 Glycine receptor subunit alpha-1 hsa04080 1MOT; 1VRY; 2M6B; 2M6I; 4X5T
58 SERPINA6 P08185 Corticosteroid-binding globulin NA 2VDX; 2VDY; 4BB2; 4C41; 4C49
59 TPI1 P60174 Triosephosphate isomerase hsa00010; hsa00051; hsa00562; hsa01100; hsa01200; hsa01230 1HTI; 1KLG; 1KLU; 1WYI; 2IAM; 2IAN; 2JK2; 2VOM; 4BR1; 4E41; 4POC; 4POD; 4UNK; 4UNL
60 IGKV1-17 P01599 Immunoglobulin kappa variable 1-17 NA NA
61 C1QC P02747 Complement C1q subcomponent subunit C hsa04610; hsa05020; hsa05133; hsa05142; hsa05150; hsa05322 1PK6; 2JG8; 2JG9; 2WNU; 2WNV
62 KRT1 P04264 Keratin, type II cytoskeletal 1 NA 4ZRY
63 AHSG P02765 Alpha-2-HS-glycoprotein NA NA
64 C8B P07358 Complement component C8 beta chain hsa04610; hsa05020; hsa05146; hsa05322 3OJY
65 SOD1 P00441 Superoxide dismutase [Cu-Zn] hsa04146; hsa04213; hsa05014; hsa05016; hsa05020
66 SHBG P04278 Sex hormone-binding globulin NA 1D2S; 1F5F; 1KDK; 1KDM; 1LHN; 1LHO; 1LHU; 1LHV; 1LHW
67 HDAC1 Q13547 Histone deacetylase 1 hsa04110; hsa04213; hsa04330; hsa04919; hsa05016; hsa05031; hsa05034; hsa05165; hsa05169; hsa05200; hsa05202; hsa05203; hsa05206; hsa05220 1TYI; 4BKX
68 VTN P04004 Vitronectin hsa04151; hsa04510; hsa04512; hsa04610; hsa05165; hsa05205 1OC0; 1S4G; 1SSU; 2JQ8; 3BT1; 3BT2; 4K24
69 S100A2 P29034 Protein S100-A2 NA 2RGI; 4DUQ
70 ITIH1 P19827 Inter-alpha-trypsin inhibitor heavy chain H1 NA NA
71 TF P02787 Serotransferrin hsa04066; hsa04216; hsa04978
72 F2 P00734 Prothrombin hsa04080; hsa04610; hsa04810
1A2C; 1A3B; 1A3E; 1A46; 1A4W; 1A5G; 1A61; 1ABI; 1ABJ; 1AD8; 1AE8; 1AFE; 1AHT; 1AI8; 1AIX; 1AWF; 1AWH; 1AY6; 1B5G; 1B7X; 1BA8; 1BB0; 1BCU; 1BHX; 1BMM; 1BMN; 1BTH; 1C1U; 1C1V; 1C1W; 1C4U; 1C4V; 1C4Y; 1C5L; 1C5N; 1C5O; 1CA8; 1D3D; 1D3P; 1D3Q; 1D3T; 1D4P; 1D6W; 1D9I; 1DE7; 1DIT; 1DM4; 1DOJ; 1DWB; 1DWC; 1DWD; 1DWE; 1DX5; 1E0F; 1EB1; 1EOJ; 1EOL; 1FPC; 1FPH; 1G30; 1G32; 1G37; 1GHV; 1GHW; 1GHX; 1GHY; 1GJ4; 1GJ5; 1H8D; 1H8I; 1HAG; 1HAH; 1HAI; 1HAO; 1HAP; 1HBT; 1HDT; 1HGT; 1HLT; 1HUT; 1HXE; 1HXF; 1IHS; 1IHT; 1JMO; 1JOU; 1JWT; 1K21; 1K22; 1KTS; 1KTT; 1LHC; 1LHD; 1LHE; 1LHF; 1LHG; 1MH0; 1MU6; 1MU8; 1MUE; 1NM6; 1NO9; 1NRN; 1NRO; 1NRP; 1NRQ; 1NRR; 1NRS; 1NT1; 1NU7; 1NU9; 1NY2; 1NZQ; 1O0D; 1O2G; 1O5G; 1OOK; 1OYT; 1P8V; 1PPB; 1QBV; 1QHR; 1QJ1; 1QJ6; 1QJ7; 1QUR; 1RD3; 1RIW; 1SB1; 1SFQ; 1SG8; 1SGI; 1SHH; 1SL3; 1SR5; 1T4U; 1T4V; 1TA2; 1TA6; 1TB6; 1TBZ; 1THP; 1THR; 1THS; 1TMB; 1TMT; 1TMU; 1TOM; 1TQ0; 1TQ7; 1TWX; 1UMA; 1UVS; 1VR1; 1VZQ; 1W7G; 1WAY; 1WBG; 1XM1; 1XMN; 1YPE; 1YPG; 1YPJ; 1YPK; 1YPL; 1YPM; 1Z71; 1Z8I; 1Z8J; 1ZGI; 1ZGV; 1ZRB; 2A0Q; 2A2X; 2A45; 2AFQ; 2ANK; 2ANM; 2B5T; 2BDY; 2BVR; 2BVS; 2BVX; 2BXT; 2BXU; 2C8W; 2C8X; 2C8Y; 2C8Z; 2C90; 2C93; 2CF8; 2CF9; 2CN0; 2FEQ; 2FES; 2GDE; 2GP9; 2H9T; 2HGT; 2HNT; 2HPP; 2HPQ; 2HWL; 2JH0; 2JH5; 2JH6; 2OD3; 2PGB; 2PGQ; 2PKS; 2PW8; 2R2M; 2THF; 2UUF; 2UUJ; 2UUK; 2V3H; 2V3O; 2ZC9; 2ZDA; 2ZDV; 2ZF0; 2ZFF; 2ZFP; 2ZFQ; 2ZFR; 2ZG0; 2ZGB; 2ZGX; 2ZHE; 2ZHF; 2ZHQ; 2ZHW; 2ZI2; 2ZIQ; 2ZNK; 2ZO3; 3B23; 3B9F; 3BEF; 3BEI; 3BF6; 3BIU; 3BIV; 3BV9; 3C1K; 3C27; 3D49; 3DA9; 3DD2; 3DHK; 3DT0; 3DUX; 3E6P; 3EE0; 3EGK; 3EQ0; 3F68; 3GIC; 3GIS; 3HAT; 3HKJ; 3HTC; 3JZ1; 3JZ2; 3K65; 3LDX; 3LU9; 3NXP; 3P17; 3P6Z; 3P70; 3PMH; 3PO1; 3QDZ; 3QGN; 3QLP; 3QTO; 3QTV; 3QWC; 3QX5; 3R3G; 3RLW; 3RLY; 3RM0; 3RM2; 3RML; 3RMM; 3RMN; 3RMO; 3S7H; 3S7K; 3SHA; 3SHC; 3SI3; 3SI4; 3SQE; 3SQH; 3SV2; 3T5F; 3TU7; 3U69; 3U8O; 3U8R; 3U8T; 3U98; 3U9A; 3UTU; 3UWJ; 3VXE; 3VXF; 4AX9; 4AYV; 4AYY; 4AZ2; 4BAH; 4BAK; 4BAM; 4BAN; 4BAO; 4BAQ; 4BOH; 4CH2; 4CH8; 4DIH; 4DII; 4DT7; 4DY7; 4E05; 4E06; 4E7R; 4H6S; 4H6T; 4HFP; 4HTC; 4HZH; 4I7Y; 4LOY; 4LXB; 4LZ1; 4LZ4; 4MLF; 4N3L; 4NZE; 4NZQ; 4O03; 4RKJ; 4RKO; 4RN6; 4THN; 4UD9; 4UDW; 4UE7; 4UEH; 4YES; 5AF9; 5AFY; 5AFZ; 5AHG; 5E8E; 5GDS; 7KME; 8KME
73 CP P00450 Ceruloplasmin hsa00860; hsa04216 1KCW; 2J5W; 4EJX; 4ENZ
74 ENO1 P06733 Alpha-enolase hsa00010; hsa01100; hsa01200; hsa01230; hsa03018; hsa04066 2PSN; 3B97
75 JCHAIN P01591 Immunoglobulin J chain NA NA
76 C4BPA P04003 C4b-binding protein alpha chain hsa04610; hsa05133 2A55; 4B0F; 5HYP; 5HYT; 5HYU; 5HZP; 5I0Q
77 SERPIND1 P05546 Heparin cofactor 2 hsa04610 1JMJ; 1JMO
78 CFH P08603 Complement factor H hsa04610; hsa05150
79 S100A9 P06702 Protein S100-A9 hsa04657 1IRJ; 1XK4; 4GGF; 4XJK; 5I8N
80 ASPA P45381 Aspartoacylase hsa00250; hsa00340; hsa01100 2I3C; 2O4H; 2O53; 2Q51; 4MRI; 4MXU; 4NFR; 4TNU
81 ESR1 P03372 Estrogen receptor hsa01522; hsa04915; hsa04917; hsa04919; hsa04961; hsa05200; hsa05205; hsa05224
82 APOA2 P02652 Apolipoprotein A-II hsa03320; hsa04979 1L6L; 2OU1
83 F13B P05160 Coagulation factor XIII B chain hsa04610 NA
84 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 hsa01522; hsa01524; hsa04068; hsa04110; hsa04115; hsa04120; hsa04144; hsa04151; hsa04218; hsa04625; hsa04919; hsa05163; hsa05165; hsa05169; hsa05200; hsa05202; hsa05203; hsa05205; hsa05206; hsa05214; hsa05215; hsa05218; hsa05219; hsa05220
85 C5 P01031 Complement C5 hsa04610; hsa05020; hsa05133; hsa05150; hsa05168; hsa05322 1CFA; 1KJS; 1XWE; 3CU7; 3HQA; 3HQB; 3KLS; 3KM9; 3PRX; 3PVM; 4A5W; 4E0S; 4P39; 4UU9
86 ITIH4 Q14624 Inter-alpha-trypsin inhibitor heavy chain H4 NA NA
87 MT1A P04731 Metallothionein-1A hsa04978 NA
88 KRT14 P02533 Keratin, type I cytoskeletal 14 hsa04915 3TNU
89 KNG1 P01042 Kininogen-1 hsa04610 1NY2; 2WOK; 4ASQ; 4ASR; 4ECB; 4ECC
90 MGMT P16455 Methylated-DNA--protein-cysteine methyltransferase NA 1EH6; 1EH7; 1EH8; 1QNT; 1T38; 1T39; 1YFH
91 HDAC8 Q9BY41 Histone deacetylase 8 hsa05034; hsa05165; hsa05203
92 APOA1 P02647 Apolipoprotein A-I hsa03320; hsa04975; hsa04977; hsa04979; hsa05143 1AV1; 1GW3; 1GW4; 1ODP; 1ODQ; 1ODR; 2A01; 2MSC; 2MSD; 2MSE; 3K2S; 3R2P; 4V6M
93 SERPINA1 P01009 Alpha-1-antitrypsin hsa04610
94 SERPINA3 P01011 Alpha-1-antichymotrypsin NA 1AS4; 1QMN; 2ACH; 3CAA; 3DLW; 4CAA
95 JUP P14923 Junction plakoglobin hsa05200; hsa05202; hsa05221; hsa05226; hsa05412 3IFQ
96 IGHA1 P01876 Ig alpha-1 chain C region NA 1IGA; 1OW0; 2QEJ; 3CHN
97 BRCC3 P46736 Lys-63-specific deubiquitinase BRCC36 hsa03440; hsa04621 NA
98 EEF1A1 P68104 Elongation factor 1-alpha 1 hsa03013; hsa05134 1SYW; 3C5J
99 HDAC4 P56524 Histone deacetylase 4 hsa04371; hsa05034; hsa05165; hsa05169; hsa05203; hsa05206 2H8N; 2O94; 2VQJ; 2VQM; 2VQO; 2VQQ; 2VQV; 2VQW; 3UXG; 3UZD; 3V31; 4CBT; 4CBY
100 IL3 P08700 Interleukin-3 hsa04060; hsa04151; hsa04210; hsa04630; hsa04640; hsa04664; hsa05200; hsa05202; hsa05221; hsa05310 1JLI
101 F12 P00748 Coagulation factor XII hsa04610 4BDW; 4BDX; 4XDE; 4XE4
102 ALDOA P04075 Fructose-bisphosphate aldolase A hsa00010; hsa00030; hsa00051; hsa01100; hsa01200; hsa01230; hsa04066 1ALD; 2ALD; 4ALD
103 MT2A P02795 Metallothionein-2 hsa04978 1MHU; 2MHU
104 NME1 P15531 Nucleoside diphosphate kinase A hsa00230; hsa00240; hsa00983; hsa01100 1JXV; 1UCN; 2HVD; 2HVE; 3L7U; 4ENO
105 PDIA3 P30101 Protein disulfide-isomerase A3 hsa04141; hsa04612; hsa05163; hsa05170 2ALB; 2DMM; 2H8L; 3F8U
106 P4HB P07237 Protein disulfide-isomerase hsa04141 1BJX; 1MEK; 1X5C; 2BJX; 2K18; 3BJ5; 3UEM; 4EKZ; 4EL1; 4JU5
107 DCD P81605 Dermcidin NA 2KSG; 2YMK
108 SEMG1 P04279 Semenogelin-1 NA NA
109 ORM2 P19652 Alpha-1-acid glycoprotein 2 NA 3APU; 3APV; 3APW; 3APX
110 TTR P02766 Transthyretin hsa04918
1BM7; 1BMZ; 1BZ8; 1BZD; 1BZE; 1DVQ; 1DVS; 1DVT; 1DVU; 1DVX; 1DVY; 1DVZ; 1E3F; 1E4H; 1E5A; 1ETA; 1ETB; 1F41; 1F64; 1F86; 1FH2; 1FHN; 1G1O; 1GKO; 1ICT; 1III; 1IIK; 1IJN; 1QAB; 1QWH; 1RLB; 1SOK; 1SOQ; 1THA; 1THC; 1TLM; 1TSH; 1TT6; 1TTA; 1TTB; 1TTC; 1TTR; 1TYR; 1TZ8; 1U21; 1X7S; 1X7T; 1Y1D; 1Z7J; 1ZCR; 1ZD6; 2B14; 2B15; 2B16; 2B77; 2B9A; 2F7I; 2F8I; 2FBR; 2FLM; 2G3X; 2G3Z; 2G4E; 2G4G; 2G5U; 2G9K; 2GAB; 2H4E; 2M5N; 2NOY; 2PAB; 2QEL; 2QGB; 2QGC; 2QGD; 2QGE; 2ROX; 2ROY; 2TRH; 2TRY; 2WQA; 3A4D; 3A4E; 3A4F; 3B56; 3BSZ; 3BT0; 3CBR; 3CFM; 3CFN; 3CFQ; 3CFT; 3CN0; 3CN1; 3CN2; 3CN3; 3CN4; 3CXF; 3D2T; 3D7P; 3DGD; 3DID; 3DJR; 3DJS; 3DJT; 3DJZ; 3DK0; 3DK2; 3DO4; 3ESN; 3ESO; 3ESP; 3FC8; 3FCB; 3GLZ; 3GPS; 3GRB; 3GRG; 3GS0; 3GS4; 3GS7; 3HJ0; 3I9A; 3I9I; 3I9P; 3IMR; 3IMS; 3IMT; 3IMU; 3IMV; 3IMW; 3IPB; 3IPE; 3KGS; 3KGT; 3KGU; 3M1O; 3NEE; 3NEO; 3NES; 3NEX; 3NG5; 3OZK; 3OZL; 3P3R; 3P3S; 3P3T; 3P3U; 3SSG; 3TCT; 3TFB; 3U2I; 3U2J; 3W3B; 4ABQ; 4ABU; 4ABV; 4ABW; 4AC2; 4AC4; 4ACT; 4ANK; 4DER; 4DES; 4DET; 4DEU; 4DEW; 4FI6; 4FI7; 4FI8; 4HIQ; 4HIS; 4HJS; 4HJT; 4HJU; 4I85; 4I87; 4I89; 4IIZ; 4IK6; 4IK7; 4IKI; 4IKJ; 4IKK; 4IKL; 4KY2; 4L1S; 4L1T; 4MAS; 4MRB; 4MRC; 4N85; 4N86; 4N87; 4PM1; 4PME; 4PMF; 4PVL; 4PVM; 4PVN; 4PWE; 4PWF; 4PWG; 4PWH; 4PWI; 4PWJ; 4PWK; 4QRF; 4QXV; 4QYA; 4TKW; 4TL4; 4TL5; 4TLK; 4TLS; 4TLT; 4TM9; 4TNE; 4TQ8; 4TQH; 4TQI; 4TQP; 4WNJ; 4WNS; 4WO0; 4Y9B; 4Y9C; 4Y9E; 4Y9F; 4Y9G; 4YDM; 4YDN; 5AKS; 5AKT; 5AKV; 5AL0; 5AL8; 5BOJ; 5CR1; 5TTR
111 IGHM P01871 Ig mu chain C region NA 2AGJ
112 C8A P07357 Complement component C8 alpha chain hsa04610; hsa05020; hsa05146; hsa05322 2QOS; 2QQH; 2RD7; 3OJY
113 MPG P29372 DNA-3-methyladenine glycosylase hsa03410 1BNK; 1EWN; 1F4R; 1F6O; 3QI5; 3UBY
114 BDKRB1 P46663 B1 bradykinin receptor hsa04020; hsa04080; hsa04610; hsa04750; hsa04810; hsa05200 NA
115 HBB P68871 Hemoglobin subunit beta hsa05143; hsa05144
1A00; 1A01; 1A0U; 1A0Z; 1A3N; 1A3O; 1ABW; 1ABY; 1AJ9; 1B86; 1BAB; 1BBB; 1BIJ; 1BUW; 1BZ0; 1BZ1; 1BZZ; 1C7B; 1C7C; 1C7D; 1CBL; 1CBM; 1CH4; 1CLS; 1CMY; 1COH; 1DKE; 1DXT; 1DXU; 1DXV; 1FN3; 1G9V; 1GBU; 1GBV; 1GLI; 1GZX; 1HAB; 1HAC; 1HBA; 1HBB; 1HBS; 1HCO; 1HDB; 1HGA; 1HGB; 1HGC; 1HHO; 1IRD; 1J3Y; 1J3Z; 1J40; 1J41; 1J7S; 1J7W; 1J7Y; 1JY7; 1K0Y; 1K1K; 1KD2; 1LFL; 1LFQ; 1LFT; 1LFV; 1LFY; 1LFZ; 1LJW; 1M9P; 1MKO; 1NEJ; 1NIH; 1NQP; 1O1I; 1O1J; 1O1K; 1O1L; 1O1M; 1O1N; 1O1O; 1O1P; 1QI8; 1QSH; 1QSI; 1QXD; 1QXE; 1R1X; 1R1Y; 1RPS; 1RQ3; 1RQ4; 1RQA; 1RVW; 1SDK; 1SDL; 1THB; 1UIW; 1VWT; 1XXT; 1XY0; 1XYE; 1XZ2; 1XZ4; 1XZ5; 1XZ7; 1XZU; 1XZV; 1Y09; 1Y0A; 1Y0C; 1Y0D; 1Y0T; 1Y0W; 1Y22; 1Y2Z; 1Y31; 1Y35; 1Y45; 1Y46; 1Y4B; 1Y4F; 1Y4G; 1Y4P; 1Y4Q; 1Y4R; 1Y4V; 1Y5F; 1Y5J; 1Y5K; 1Y7C; 1Y7D; 1Y7G; 1Y7Z; 1Y83; 1Y85; 1Y8W; 1YDZ; 1YE0; 1YE1; 1YE2; 1YEN; 1YEO; 1YEQ; 1YEU; 1YEV; 1YFF; 1YG5; 1YGD; 1YGF; 1YH9; 1YHE; 1YHR; 1YIE; 1YIH; 1YVQ; 1YVT; 1YZI; 2D5Z; 2D60; 2DN1; 2DN2; 2DN3; 2DXM; 2H35; 2HBC; 2HBD; 2HBE; 2HBF; 2HBS; 2HCO; 2HHB; 2HHD; 2HHE; 2M6Z; 2W6V; 2W72; 2YRS; 3B75; 3D17; 3D7O; 3DUT; 3HHB; 3HXN; 3IC0; 3IC2; 3KMF; 3NL7; 3NMM; 3ODQ; 3ONZ; 3OO4; 3OO5; 3P5Q; 3QJB; 3QJC; 3QJD; 3QJE; 3R5I; 3S65; 3S66; 3SZK; 3W4U; 3WCP; 3WHM; 4FC3; 4HHB; 4IJ2; 4L7Y; 4M4A; 4M4B; 4MQC; 4MQG; 4MQH; 4MQI; 4N7N; 4N7O; 4N7P; 4N8T; 4NI0; 4NI1; 4ROL; 4ROM; 4WJG; 4X0I; 4X0L; 4XS0; 5E29; 5E6E; 5EE4; 6HBW
116 CPN1 P15169 Carboxypeptidase N catalytic chain NA 2NSM
117 GAPDHS O14556 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific hsa00010; hsa01100 3H9E; 3PFW
118 ITIH3 Q06033 Inter-alpha-trypsin inhibitor heavy chain H3 NA NA
119 PDCD6 O75340 Programmed cell death protein 6 NA 2ZN8; 2ZN9; 2ZND; 2ZNE; 2ZRS; 2ZRT; 3AAJ; 3AAK; 3WXA
120 A2M P01023 Alpha-2-macroglobulin hsa04610 1BV8; 2P9R; 4ACQ
121 C4BPB P20851 C4b-binding protein beta chain hsa04610; hsa05133 NA
122 C4B P0C0L5 Complement C4-B NA 4XAM
123 CLU P10909 Clusterin hsa04610 NA
124 AGT P01019 Angiotensinogen hsa04614; hsa04924 1N9U; 1N9V; 2JP8; 2WXW; 2X0B; 3CK0; 3WOO; 3WOR; 4AA1; 4APH; 4FYS


20 predicted interactions (targets) of input drug (DB01593): Zinc
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 PLG P00747 Plasminogen hsa04080; hsa04610; hsa05150; hsa05164 71.7%
2 PGR P06401 Progesterone receptor hsa04114; hsa04914; hsa04915; hsa05224 1A28; 1E3K; 1SQN; 1SR7; 1ZUC; 2C7A; 2OVH; 2OVM; 2W8Y; 3D90; 3G8O; 3HQ5; 3KBA; 3ZR7; 3ZRA; 3ZRB; 4A2J; 4APU; 4OAR 60.8%
3 APOD P05090 Apolipoprotein D NA 2APD; 2HZQ; 2HZR 60.1%
4 RPSA P08865 40S ribosomal protein SA hsa03010 3BCH; 4UG0; 4V6X; 5A2Q; 5AJ0 58.7%
5 SERPINF2 P08697 Alpha-2-antiplasmin hsa04610 NA 58.4%
6 APOC2 P02655 Apolipoprotein C-II hsa04979 1BY6; 1I5J; 1O8T; 1SOH 58.1%
7 OPRK1 P41145 Kappa-type opioid receptor hsa04080 2A0D; 2IQN; 4DJH 57.9%
8 OPRM1 P35372 Mu-type opioid receptor hsa04080; hsa04915; hsa05032 NA 57.7%
9 PRDX6 P30041 Peroxiredoxin-6 hsa01100 1PRX 57.0%
10 GSS P48637 Glutathione synthetase hsa00270; hsa00480; hsa01100; hsa04216 2HGS 56.9%
11 AZGP1 P25311 Zinc-alpha-2-glycoprotein NA 1T7V; 1T7W; 1T7X; 1T7Y; 1T7Z; 1T80; 1ZAG; 3ES6 56.1%
12 HSP90AA1 P07900 Heat shock protein HSP 90-alpha hsa04141; hsa04151; hsa04217; hsa04612; hsa04621; hsa04657; hsa04659; hsa04914; hsa04915; hsa05200; hsa05215; hsa05418
1BYQ; 1OSF; 1UY6; 1UY7; 1UY8; 1UY9; 1UYC; 1UYD; 1UYE; 1UYF; 1UYG; 1UYH; 1UYI; 1UYK; 1UYL; 1YC1; 1YC3; 1YC4; 1YER; 1YES; 1YET; 2BSM; 2BT0; 2BUG; 2BYH; 2BYI; 2BZ5; 2C2L; 2CCS; 2CCT; 2CCU; 2CDD; 2FWY; 2FWZ; 2H55; 2JJC; 2K5B; 2QF6; 2QFO; 2QG0; 2QG2; 2UWD; 2VCI; 2VCJ; 2WI1; 2WI2; 2WI3; 2WI4; 2WI5; 2WI6; 2WI7; 2XAB; 2XDK; 2XDL; 2XDS; 2XDU; 2XDX; 2XHR; 2XHT; 2XHX; 2XJG; 2XJJ; 2XJX; 2XK2; 2YE2; 2YE3; 2YE4; 2YE5; 2YE6; 2YE7; 2YE8; 2YE9; 2YEA; 2YEB; 2YEC; 2YED; 2YEE; 2YEF; 2YEG; 2YEH; 2YEI; 2YEJ; 2YI0; 2YI5; 2YI6; 2YI7; 2YJW; 2YJX; 2YK2; 2YK9; 2YKB; 2YKC; 2YKE; 2YKI; 2YKJ; 3B24; 3B25; 3B26; 3B27; 3B28; 3BM9; 3BMY; 3D0B; 3EKO; 3EKR; 3FT5; 3FT8; 3HEK; 3HHU; 3HYY; 3HYZ; 3HZ1; 3HZ5; 3INW; 3INX; 3K97; 3K98; 3K99; 3MNR; 3O0I; 3OW6; 3OWB; 3OWD; 3Q6M; 3Q6N; 3QDD; 3QTF; 3R4M; 3R4N; 3R4O; 3R4P; 3R91; 3R92; 3RKZ; 3RLP; 3RLQ; 3RLR; 3T0H; 3T0Z; 3T10; 3T1K; 3T2S; 3TUH; 3VHA; 3VHC; 3VHD; 3WHA; 3WQ9; 4AIF; 4AWO; 4AWP; 4AWQ; 4B7P; 4BQJ; 4CGQ; 4CGU; 4CGV; 4CGW; 4CWF; 4CWN; 4CWO; 4CWP; 4CWQ; 4CWR; 4CWS; 4CWT; 4EEH; 4EFT; 4EFU; 4EGH; 4EGI; 4EGK; 4FCP; 4FCQ; 4FCR; 4HY6; 4JQL; 4L8Z; 4L90; 4L91; 4L93; 4L94; 4LWE; 4LWF; 4LWG; 4LWH; 4LWI; 4NH7; 4NH8; 4O04; 4O05; 4O07; 4O09; 4O0B; 4R3M; 4U93; 4W7T; 4XIP; 4XIQ; 4XIR; 4XIT
 55.5%
13 PSME1 Q06323 Proteasome activator complex subunit 1 hsa03050; hsa04612 1AVO 55.3%
14 IGHG1 P01857 Ig gamma-1 chain C region NA
1AJ7; 1AQK; 1BEY; 1D5B; 1D5I; 1D6V; 1DFB; 1DN2; 1E4K; 1FC1; 1FC2; 1FCC; 1GAF; 1H3T; 1H3U; 1H3V; 1H3W; 1H3X; 1H3Y; 1HKL; 1HZH; 1I7Z; 1L6X; 1N7M; 1OP3; 1OQO; 1OQX; 1T83; 1T89; 1VGE; 2DTS; 2GJ7; 2I5Y; 2IWG; 2J6E; 2JB5; 2JB6; 2O5X; 2O5Y; 2O5Z; 2OSL; 2QAD; 2QL1; 2QQK; 2QQL; 2QQN; 2QR0; 2R56; 2RCJ; 2RCS; 2VXQ; 2WAH; 3AGV; 3AVE; 3AY4; 3B2U; 3B2V; 3BDY; 3BE1; 3BKY; 3BN9; 3BQU; 3C08; 3C09; 3C2S; 3CFJ; 3CFK; 3CSY; 3D0L; 3D0V; 3D6G; 3D85; 3DJ9; 3DNK; 3DO3; 3DRO; 3DRQ; 3DVG; 3DVN; 3EYF; 3EYO; 3EYQ; 3FJT; 3O11; 3RY6; 3S7G; 3SGJ; 3SGK; 3TV3; 3TWC; 3TYG; 3U0W; 3U7W; 3U7Y; 3V7M; 3V8C; 3V95; 3WJJ; 3WJL; 3WKN; 3WN5; 4ACP; 4B7I; 4BM7; 4BSV; 4BSW; 4BYH; 4CDH; 4D9Q; 4D9R; 4DAG; 4DZ8; 4EOW; 4J12; 4KU1; 4LLD; 4LLM; 4LLQ; 4N0U; 4NQS; 4NQT; 4NQU; 4NWT; 4NWU; 4O4Y; 4O51; 4Q6Y; 4Q74; 4Q7D; 4W4N; 4W4O; 4WI2; 4WI3; 4WI4; 4WI5; 4WI6; 4WI7; 4WI8; 4WI9; 4X4M; 4X98; 4X99; 4ZNE; 5BW7
 55.0%
15 EIF4A1 P60842 Eukaryotic initiation factor 4A-I hsa03013 2G9N; 2ZU6; 3EIQ 54.8%
16 EEF1A1L14 Q96RE1 Translation elongation factor 1 alpha 1-like 14 NA NA 54.6%
17 HEPHL1 Q6MZM0 Hephaestin-like protein 1 NA NA 54.5%
18 PKM P14618 Pyruvate kinase PKM hsa00010; hsa00230; hsa00620; hsa01100; hsa01200; hsa01230; hsa04922; hsa04930; hsa05165; hsa05203; hsa05230 54.3%
19 GOT1 P17174 Aspartate aminotransferase, cytoplasmic hsa00220; hsa00250; hsa00270; hsa00330; hsa00350; hsa00360; hsa00400; hsa01100; hsa01200; hsa01210; hsa01230 3II0; 3WZF 53.8%
20 APOC3 P02656 Apolipoprotein C-III hsa03320; hsa04979 2JQ3 53.7%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.