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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB12010
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb


303 known interactions (targets) of input drug (DB12010): Fostamatinib
No. Gene UniProt ID Protein Name Pathway PDB
1 DYRK1A Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A NA 2VX3; 2WO6; 3ANQ; 3ANR; 4AZE; 4MQ1; 4MQ2; 4NCT; 4YLJ; 4YLK; 4YLL; 4YU2; 5AIK
2 ZAK Q9NYL2 Mitogen-activated protein kinase kinase kinase MLT hsa04010 NA
3 PIP4K2B P78356 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta hsa00562; hsa04070; hsa04810 1BO1; 3WZZ; 3X01; 3X02; 3X03; 3X04; 3X05; 3X06; 3X07; 3X08; 3X09; 3X0A; 3X0B; 3X0C
4 STK17A Q9UEE5 Serine/threonine-protein kinase 17A NA NA
5 FYN P06241 Tyrosine-protein kinase Fyn hsa04071; hsa04072; hsa04360; hsa04380; hsa04510; hsa04520; hsa04611; hsa04650; hsa04660; hsa04664; hsa04725; hsa05020; hsa05130; hsa05162; hsa05416
6 FLT3 P36888 Receptor-type tyrosine-protein kinase FLT3 hsa04010; hsa04014; hsa04151; hsa04640; hsa05200; hsa05202; hsa05221; hsa05230 1RJB; 3QS7; 3QS9; 4RT7; 4XUF
7 CHEK2 O96017 Serine/threonine-protein kinase Chk2 hsa04110; hsa04115; hsa04218; hsa05166
8 STK26 Q9P289 Serine/threonine-protein kinase 26 NA 3GGF; 3W8I; 4FZA; 4FZD; 4FZF; 4GEH
9 PDE5A O76074 cGMP-specific 3',5'-cyclic phosphodiesterase hsa00230; hsa04022
10 SIK3 Q9Y2K2 Serine/threonine-protein kinase SIK3 NA NA
11 BMPR2 Q13873 Bone morphogenetic protein receptor type-2 hsa04060; hsa04350; hsa04360; hsa04390; hsa04550; hsa05206; hsa05418 2HLQ; 3G2F
12 MYO3A Q8NEV4 Myosin-IIIa NA NA
13 DCLK3 Q9C098 Serine/threonine-protein kinase DCLK3 NA NA
14 MARK2 Q7KZI7 Serine/threonine-protein kinase MARK2 NA 3IEC; 5EAK; 5KZ7; 5KZ8
15 CSK P41240 Tyrosine-protein kinase CSK hsa05120 1BYG; 1CSK; 3D7T; 3D7U; 3EAC; 3EAZ
16 TLK2 Q86UE8 Serine/threonine-protein kinase tousled-like 2 NA NA
17 STK32A Q8WU08 Serine/threonine-protein kinase 32A NA 4FR4
18 TNK2 Q07912 Activated CDC42 kinase 1 NA 1CF4; 1U46; 1U4D; 1U54; 3EQP; 3EQR; 4EWH; 4HZR; 4HZS; 4ID7
19 MST1R Q04912 Macrophage-stimulating protein receptor NA 3PLS; 4FWW; 4QT8
20 CIT O14578 Citron Rho-interacting kinase NA NA
21 ABL1 P00519 Tyrosine-protein kinase ABL1 hsa04012; hsa04014; hsa04110; hsa04360; hsa04722; hsa05130; hsa05131; hsa05200; hsa05206; hsa05220; hsa05416
22 RIPK2 O43353 Receptor-interacting serine/threonine-protein kinase 2 hsa04621; hsa04722; hsa05131; hsa05152 2N7Z; 2N83; 4C8B; 5AR2; 5AR3; 5AR4; 5AR5; 5AR7; 5AR8; 5J79; 5J7B; 5NG0; 5NG2; 5NG3; 5W5J; 5W5O; 6ES0
23 MAP3K3 Q99759 Mitogen-activated protein kinase kinase kinase 3 hsa04010; hsa04722; hsa04912; hsa05166 2C60; 2JRH; 2O2V; 2PPH; 4Y5O; 4YL6
24 PIM3 Q86V86 Serine/threonine-protein kinase pim-3 NA NA
25 TNNI3K Q59H18 Serine/threonine-protein kinase TNNI3K NA 4YFF; 4YFI
26 CAMK2B Q13554 Calcium/calmodulin-dependent protein kinase type II subunit beta hsa04012; hsa04020; hsa04024; hsa04066; hsa04114; hsa04217; hsa04261; hsa04310; hsa04360; hsa04713; hsa04720; hsa04722; hsa04725; hsa04728; hsa04740; hsa04750; hsa04911; hsa04912; hsa04916; hsa04921; hsa04922; hsa04925; hsa04934; hsa04971; hsa05031; hsa05152; hsa05200; hsa05205; hsa05214 3BHH
27 MYLK3 Q32MK0 Myosin light chain kinase 3 hsa04020; hsa04022; hsa04270; hsa04371; hsa04510; hsa04611; hsa04810; hsa04921; hsa04971 NA
28 STK16 O75716 Serine/threonine-protein kinase 16 NA 2BUJ
29 ANKK1 Q8NFD2 Ankyrin repeat and protein kinase domain-containing protein 1 NA NA
30 PKMYT1 Q99640 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase hsa04110; hsa04114; hsa04914 3P1A; 5VCV; 5VCW; 5VCX; 5VCY; 5VCZ; 5VD0; 5VD1; 5VD3
31 CAMK2D Q13557 Calcium/calmodulin-dependent protein kinase type II subunit delta hsa04012; hsa04020; hsa04024; hsa04066; hsa04114; hsa04217; hsa04261; hsa04310; hsa04360; hsa04713; hsa04720; hsa04722; hsa04725; hsa04728; hsa04740; hsa04750; hsa04911; hsa04912; hsa04916; hsa04921; hsa04922; hsa04925; hsa04934; hsa04971; hsa05031; hsa05152; hsa05200; hsa05205; hsa05214 2VN9; 2W2C; 2WEL; 3GP2
32 SIK1 P57059 Serine/threonine-protein kinase SIK1 NA NA
33 ROCK2 O75116 Rho-associated protein kinase 2 hsa04022; hsa04024; hsa04062; hsa04071; hsa04270; hsa04310; hsa04360; hsa04510; hsa04530; hsa04611; hsa04670; hsa04810; hsa04921; hsa05130; hsa05131; hsa05132; hsa05163; hsa05200; hsa05205 4L6Q; 4WOT
34 LIMK1 P53667 LIM domain kinase 1 hsa04360; hsa04666; hsa04810; hsa05170 3S95
35 PTK6 Q13882 Protein-tyrosine kinase 6 NA 1RJA; 2KGT
36 DCLK2 Q8N568 Serine/threonine-protein kinase DCLK2 NA NA
37 STK17B O94768 Serine/threonine-protein kinase 17B NA 3LM0; 3LM5
38 FGFR3 P22607 Fibroblast growth factor receptor 3 hsa01521; hsa04010; hsa04014; hsa04015; hsa04144; hsa04151; hsa04550; hsa04810; hsa05200; hsa05206; hsa05219; hsa05230 1RY7; 2LZL; 4K33
39 LIMK2 P53671 LIM domain kinase 2 hsa04360; hsa04666; hsa04810; hsa05170 1X6A; 4TPT; 5NXD
40 JAK2 O60674 Tyrosine-protein kinase JAK2 hsa01521; hsa04062; hsa04151; hsa04217; hsa04550; hsa04630; hsa04658; hsa04659; hsa04725; hsa04917; hsa04920; hsa04933; hsa05140; hsa05145; hsa05152; hsa05162; hsa05164; hsa05167; hsa05168; hsa05200
41 AURKB Q96GD4 Aurora kinase B NA 4AF3
42 CAMK1G Q96NX5 Calcium/calmodulin-dependent protein kinase type 1G hsa04921; hsa04925 2JAM
43 EIF2AK1 Q9BQI3 Eukaryotic translation initiation factor 2-alpha kinase 1 hsa04141; hsa05160; hsa05162; hsa05164; hsa05168; hsa05169 NA
44 MAP3K15 Q6ZN16 Mitogen-activated protein kinase kinase kinase 15 NA NA
45 SRC P12931 Proto-oncogene tyrosine-protein kinase Src hsa01521; hsa01522; hsa04012; hsa04015; hsa04062; hsa04137; hsa04144; hsa04360; hsa04370; hsa04510; hsa04520; hsa04530; hsa04540; hsa04611; hsa04625; hsa04727; hsa04750; hsa04810; hsa04912; hsa04915; hsa04917; hsa04919; hsa04921; hsa04926; hsa05100; hsa05120; hsa05131; hsa05152; hsa05161; hsa05163; hsa05167; hsa05203; hsa05205; hsa05219; hsa05418
46 TNK1 Q13470 Non-receptor tyrosine-protein kinase TNK1 NA NA
47 MET P08581 Hepatocyte growth factor receptor hsa01521; hsa04010; hsa04014; hsa04015; hsa04151; hsa04360; hsa04510; hsa04520; hsa05100; hsa05120; hsa05144; hsa05200; hsa05202; hsa05205; hsa05206; hsa05211; hsa05218; hsa05225; hsa05226; hsa05230
48 FER P16591 Tyrosine-protein kinase Fer hsa04520 2KK6
49 MYLK Q15746 Myosin light chain kinase, smooth muscle hsa04020; hsa04022; hsa04270; hsa04371; hsa04510; hsa04611; hsa04810; hsa04921; hsa04971 2CQV; 2K0F; 2YR3; 5JQA; 5JTH
50 CLK1 P49759 Dual specificity protein kinase CLK1 hsa05134 1Z57; 2VAG
51 MAP3K6 O95382 Mitogen-activated protein kinase kinase kinase 6 hsa04010 NA
52 PIP4K2C Q8TBX8 Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma hsa00562; hsa04070; hsa04810 2GK9
53 STK35 Q8TDR2 Serine/threonine-protein kinase 35 NA NA
54 DAPK1 P53355 Death-associated protein kinase 1 hsa04140; hsa05200; hsa05219
55 NEK11 Q8NG66 Serine/threonine-protein kinase Nek11 NA NA
56 BLK P51451 Tyrosine-protein kinase Blk NA NA
57 STK3 Q13188 Serine/threonine-protein kinase 3 hsa04010; hsa04390; hsa04392 3WWS; 4HKD; 4L0N; 4LG4; 4LGD; 4OH9; 5BRM; 5DH3; 6AO5
58 TAOK2 Q9UL54 Serine/threonine-protein kinase TAO2 hsa04010 NA
59 PKN2 Q16513 Serine/threonine-protein kinase N2 hsa04151; hsa05132 4CRS; 4RRV
60 GSK3A P49840 Glycogen synthase kinase-3 alpha hsa04062; hsa04728; hsa04932 2DFM
61 MAP2K5 Q13163 Dual specificity mitogen-activated protein kinase kinase 5 hsa04010; hsa04540; hsa04722; hsa04921; hsa05418 2NPT; 2O2V; 4IC7
62 RIPK1 Q13546 Receptor-interacting serine/threonine-protein kinase 1 hsa04064; hsa04210; hsa04217; hsa04620; hsa04621; hsa04622; hsa04623; hsa04668; hsa05160; hsa05163; hsa05169; hsa05170 4ITH; 4ITI; 4ITJ; 4NEU; 5HX6; 5TX5
63 FLT1 P17948 Vascular endothelial growth factor receptor 1 hsa04010; hsa04014; hsa04015; hsa04066; hsa04151; hsa04510; hsa05202; hsa05323 1FLT; 1QSV; 1QSZ; 1QTY; 1RV6; 2XAC; 3HNG; 4CKV; 4CL7
64 MINK1 Q8N4C8 Misshapen-like kinase 1 NA NA
65 TYK2 P29597 Non-receptor tyrosine-protein kinase TYK2 hsa04217; hsa04380; hsa04621; hsa04630; hsa04658; hsa04659; hsa05145; hsa05160; hsa05162; hsa05164; hsa05165; hsa05167; hsa05168; hsa05169 3LXN; 3LXP; 3NYX; 3NZ0; 3ZON; 4GFO; 4GIH; 4GII; 4GJ2; 4GJ3; 4GVJ; 4OLI; 4PO6; 4PY1; 4WOV; 5C01; 5C03
66 DYRK1B Q9Y463 Dual specificity tyrosine-phosphorylation-regulated kinase 1B NA NA
67 MAP2K2 P36507 Dual specificity mitogen-activated protein kinase kinase 2 hsa01521; hsa01522; hsa04010; hsa04012; hsa04014; hsa04015; hsa04022; hsa04024; hsa04066; hsa04068; hsa04071; hsa04072; hsa04140; hsa04150; hsa04151; hsa04210; hsa04218; hsa04270; hsa04370; hsa04371; hsa04540; hsa04550; hsa04620; hsa04650; hsa04660; hsa04662; hsa04664; hsa04720; hsa04722; hsa04730; hsa04810; hsa04910; hsa04912; hsa04915; hsa04916; hsa04917; hsa04919; hsa04921; hsa04926; hsa04934; hsa05020; hsa05161; hsa05163; hsa05164; hsa05165; hsa05167; hsa05170; hsa05200; hsa05205; hsa05206; hsa05210; hsa05211; hsa05213; hsa05214; hsa05215; hsa05216; hsa05218; hsa05219; hsa05220; hsa05221; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231 1S9I; 4H3Q
68 EPHB6 O15197 Ephrin type-B receptor 6 hsa04360 NA
69 LYN P07948 Tyrosine-protein kinase Lyn hsa04062; hsa04064; hsa04611; hsa04662; hsa04664; hsa04666; hsa04730; hsa05120; hsa05167; hsa05169; hsa05203 1W1F; 1WA7; 3A4O
70 MAPK4 P31152 Mitogen-activated protein kinase 4 hsa04657 NA
71 MAP3K4 Q9Y6R4 Mitogen-activated protein kinase kinase kinase 4 hsa04010; hsa04912 NA
72 STK33 Q9BYT3 Serine/threonine-protein kinase 33 NA NA
73 PRKAB1 Q9Y478 5'-AMP-activated protein kinase subunit beta-1 hsa04068; hsa04152; hsa04211; hsa04213; hsa04371; hsa04530; hsa04710; hsa04714; hsa04910; hsa04920; hsa04921; hsa04922; hsa04931; hsa04932; hsa05410 4CFE; 4CFF
74 GAK O14976 Cyclin-G-associated kinase NA 4C57; 4C58; 4C59; 4O38; 4Y8D
75 MYLK4 Q86YV6 Myosin light chain kinase family member 4 hsa04020; hsa04022; hsa04270; hsa04371; hsa04510; hsa04611; hsa04810; hsa04921; hsa04971 2X4F
76 MAPK13 O15264 Mitogen-activated protein kinase 13 hsa01522; hsa04010; hsa04015; hsa04068; hsa04071; hsa04218; hsa04261; hsa04370; hsa04380; hsa04550; hsa04611; hsa04620; hsa04621; hsa04622; hsa04625; hsa04657; hsa04658; hsa04659; hsa04660; hsa04664; hsa04668; hsa04670; hsa04714; hsa04722; hsa04723; hsa04728; hsa04750; hsa04912; hsa04914; hsa04917; hsa04926; hsa04933; hsa05014; hsa05120; hsa05131; hsa05132; hsa05133; hsa05140; hsa05142; hsa05145; hsa05152; hsa05160; hsa05163; hsa05164; hsa05167; hsa05169; hsa05170; hsa05205; hsa05418 3COI; 4EYJ; 4EYM; 4MYG; 4YNO
77 AXL P30530 Tyrosine-protein kinase receptor UFO hsa01521 2C5D; 4RA0; 5U6B; 5VXZ
78 CAMK1D Q8IU85 Calcium/calmodulin-dependent protein kinase type 1D hsa04921; hsa04925 2JC6
79 MAP4K2 Q12851 Mitogen-activated protein kinase kinase kinase kinase 2 hsa04010 NA
80 ALOX5 P09917 Arachidonate 5-lipoxygenase hsa00590; hsa01100; hsa04664; hsa04726; hsa04913; hsa05145 2ABV; 3O8Y; 3V92; 3V98; 3V99
81 STK38 Q15208 Serine/threonine-protein kinase 38 NA 1PSB
82 RPS6KA3 P51812 Ribosomal protein S6 kinase alpha-3 hsa04010; hsa04114; hsa04150; hsa04714; hsa04720; hsa04722; hsa04914; hsa04931 4D9T; 4D9U; 4JG6; 4JG7; 4JG8; 4NUS; 4NW5; 4NW6; 5D9K; 5D9L
83 NEK3 P51956 Serine/threonine-protein kinase Nek3 NA NA
84 RIOK3 O14730 Serine/threonine-protein kinase RIO3 NA NA
85 BMPR1B O00238 Bone morphogenetic protein receptor type-1B hsa04060; hsa04350; hsa04360; hsa04390; hsa04550; hsa05418 3MDY
86 SLK Q9H2G2 STE20-like serine/threonine-protein kinase hsa04114 2J51; 2JFL; 2JFM; 2UV2; 4USF
87 EPHA2 P29317 Ephrin type-A receptor 2 hsa04010; hsa04014; hsa04015; hsa04151; hsa04360 1MQB; 2E8N; 2K9Y; 2KSO; 2X10; 2X11; 3C8X; 3CZU; 3FL7; 3HEI; 3HPN; 3KKA; 3MBW; 3MX0; 3SKJ; 4P2K; 4PDO; 4TRL
88 PAK3 O75914 Serine/threonine-protein kinase PAK 3 hsa04012; hsa04014; hsa04360; hsa04510; hsa04660; hsa04810; hsa05170; hsa05211 6FD3
89 MAPK15 Q8TD08 Mitogen-activated protein kinase 15 hsa04657 NA
90 ACVR1 Q04771 Activin receptor type-1 hsa04060; hsa04350; hsa04550; hsa05418 3H9R; 3MTF; 3OOM; 3Q4U; 4BGG; 4C02; 4DYM
91 IRAK3 Q9Y616 Interleukin-1 receptor-associated kinase 3 hsa04722 5UKE
92 GSK3B P49841 Glycogen synthase kinase-3 beta hsa01521; hsa04012; hsa04062; hsa04110; hsa04150; hsa04151; hsa04310; hsa04340; hsa04360; hsa04390; hsa04510; hsa04550; hsa04657; hsa04660; hsa04662; hsa04722; hsa04728; hsa04910; hsa04916; hsa04917; hsa04919; hsa04931; hsa04932; hsa04934; hsa05010; hsa05160; hsa05162; hsa05163; hsa05164; hsa05165; hsa05166; hsa05167; hsa05169; hsa05200; hsa05210; hsa05213; hsa05215; hsa05217; hsa05224; hsa05225; hsa05226
93 FGR P09769 Tyrosine-protein kinase Fgr hsa04062; hsa05169 NA
94 PRKCI P41743 Protein kinase C iota type hsa04015; hsa04144; hsa04390; hsa04530; hsa04611; hsa04910; hsa05165 1VD2; 1WMH; 1ZRZ; 3A8W; 3A8X; 3ZH8
95 TEK Q02763 Angiopoietin-1 receptor hsa04010; hsa04014; hsa04015; hsa04066; hsa04151; hsa05323 1FVR; 2GY5; 2GY7; 2OO8; 2OSC; 2P4I; 2WQB; 3BEA; 3L8P; 4K0V; 4X3J
96 CDK16 Q00536 Cyclin-dependent kinase 16 NA 3MTL
97 FES P07332 Tyrosine-protein kinase Fes/Fps hsa04360 1WQU; 2DCR; 3BKB; 3CBL; 3CD3; 4DYL; 4E93
98 PLK3 Q9H4B4 Serine/threonine-protein kinase PLK3 hsa04068; hsa04625; hsa05152 4B6L
99 ACVR1B P36896 Activin receptor type-1B hsa04060; hsa04350; hsa04550 NA
100 MAP4K1 Q92918 Mitogen-activated protein kinase kinase kinase kinase 1 hsa04010 NA
101 CSN3 P07498 Kappa-casein NA NA
102 STK36 Q9NRP7 Serine/threonine-protein kinase 36 NA NA
103 IKBKB O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta hsa01523; hsa04010; hsa04014; hsa04062; hsa04064; hsa04068; hsa04150; hsa04151; hsa04210; hsa04380; hsa04620; hsa04621; hsa04622; hsa04623; hsa04625; hsa04657; hsa04658; hsa04659; hsa04660; hsa04662; hsa04668; hsa04722; hsa04910; hsa04920; hsa04930; hsa04931; hsa04932; hsa05120; hsa05131; hsa05142; hsa05145; hsa05160; hsa05161; hsa05163; hsa05164; hsa05165; hsa05166; hsa05167; hsa05168; hsa05169; hsa05170; hsa05200; hsa05206; hsa05212; hsa05215; hsa05220; hsa05221; hsa05222; hsa05418 3BRT; 3BRV; 4E3C; 4KIK
104 HIPK2 Q9H2X6 Homeodomain-interacting protein kinase 2 hsa04218 NA
105 NEK1 Q96PY6 Serine/threonine-protein kinase Nek1 NA 4APC; 4B9D
106 BMP2K Q9NSY1 BMP-2-inducible protein kinase hsa05202 4W9W; 4W9X; 5I3O; 5I3R; 5IKW
107 CDKL1 Q00532 Cyclin-dependent kinase-like 1 NA 4AGU
108 MAP4K4 O95819 Mitogen-activated protein kinase kinase kinase kinase 4 hsa04010 4OBO; 4OBP; 4OBQ; 4RVT; 4U3Y; 4U3Z; 4U40; 4U41; 4U42; 4U43; 4U44; 4U45; 4ZK5; 4ZP5; 5DI1; 5J95
109 PAK2 Q13177 Serine/threonine-protein kinase PAK 2 hsa04010; hsa04012; hsa04014; hsa04360; hsa04510; hsa04660; hsa04810; hsa05170; hsa05211 3PCS
110 STK39 Q9UEW8 STE20/SPS1-related proline-alanine-rich protein kinase NA NA
111 NTRK3 Q16288 NT-3 growth factor receptor hsa04722; hsa05230 1WWC; 3V5Q; 4YMJ
112 ALK Q9UM73 ALK tyrosine kinase receptor hsa05200; hsa05223
113 CLASP1 Q7Z460 CLIP-associating protein 1 NA 4K92
114 FAAH O00519 Fatty-acid amide hydrolase 1 hsa04723 NA
115 CAMK1 Q14012 Calcium/calmodulin-dependent protein kinase type 1 hsa04921; hsa04925 4FG7; 4FG8; 4FG9; 4FGB
116 PAK6 Q9NQU5 Serine/threonine-protein kinase PAK 6 NA 2C30; 2ODB; 4KS7; 4KS8
117 VMAT2 Q99870 Vesicle monoamine transporter type 2 NA NA
118 CAMK2A Q9UQM7 Calcium/calmodulin-dependent protein kinase type II subunit alpha hsa04012; hsa04020; hsa04024; hsa04066; hsa04114; hsa04217; hsa04261; hsa04310; hsa04360; hsa04713; hsa04720; hsa04722; hsa04725; hsa04728; hsa04740; hsa04750; hsa04911; hsa04912; hsa04916; hsa04921; hsa04922; hsa04925; hsa04934; hsa04971; hsa05031; hsa05152; hsa05200; hsa05205; hsa05214 2VZ6; 3SOA
119 TGFBR1 P36897 TGF-beta receptor type-1 hsa04010; hsa04060; hsa04068; hsa04144; hsa04218; hsa04350; hsa04371; hsa04380; hsa04390; hsa04520; hsa04659; hsa04926; hsa04933; hsa05142; hsa05161; hsa05166; hsa05200; hsa05210; hsa05212; hsa05220; hsa05225; hsa05226
120 SBK1 Q52WX2 Serine/threonine-protein kinase SBK1 NA NA
121 INSR P06213 Insulin receptor hsa04010; hsa04014; hsa04015; hsa04022; hsa04066; hsa04068; hsa04072; hsa04150; hsa04151; hsa04152; hsa04211; hsa04213; hsa04520; hsa04910; hsa04913; hsa04923; hsa04930; hsa04931; hsa04932; hsa04960
122 PRKCE Q02156 Protein kinase C epsilon type hsa04022; hsa04071; hsa04270; hsa04371; hsa04530; hsa04666; hsa04750; hsa04925; hsa04930; hsa04931; hsa04933; hsa05206 2WH0
123 MTOR P42345 Serine/threonine-protein kinase mTOR hsa01521; hsa01522; hsa04012; hsa04066; hsa04072; hsa04136; hsa04140; hsa04150; hsa04151; hsa04152; hsa04211; hsa04213; hsa04218; hsa04371; hsa04630; hsa04659; hsa04714; hsa04910; hsa04919; hsa04920; hsa04930; hsa04931; hsa05163; hsa05165; hsa05167; hsa05170; hsa05200; hsa05205; hsa05206; hsa05210; hsa05212; hsa05214; hsa05215; hsa05221; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231 1AUE; 1FAP; 1NSG; 2FAP; 2GAQ; 2NPU; 2RSE; 3FAP; 4DRH; 4DRI; 4DRJ; 4FAP; 4JSN; 4JSP; 4JSV; 4JSX; 4JT5; 4JT6
124 MAPK9 P45984 Mitogen-activated protein kinase 9 hsa01522; hsa04010; hsa04012; hsa04014; hsa04024; hsa04068; hsa04071; hsa04137; hsa04140; hsa04141; hsa04210; hsa04215; hsa04217; hsa04310; hsa04380; hsa04510; hsa04530; hsa04620; hsa04621; hsa04622; hsa04625; hsa04657; hsa04658; hsa04659; hsa04660; hsa04664; hsa04668; hsa04722; hsa04723; hsa04728; hsa04750; hsa04910; hsa04912; hsa04914; hsa04917; hsa04920; hsa04926; hsa04930; hsa04931; hsa04932; hsa04933; hsa05120; hsa05131; hsa05132; hsa05133; hsa05142; hsa05145; hsa05152; hsa05160; hsa05161; hsa05164; hsa05167; hsa05168; hsa05169; hsa05170; hsa05200; hsa05210; hsa05212; hsa05231; hsa05418 3E7O; 3NPC
125 MAPK7 Q13164 Mitogen-activated protein kinase 7 hsa04010; hsa04540; hsa04657; hsa04722; hsa04912; hsa04921; hsa05206; hsa05418 2Q8Y; 4B99; 4IC7; 4IC8; 4ZSG; 4ZSJ; 4ZSL; 5BYY; 5BYZ
126 SLC29A1 Q99808 Equilibrative nucleoside transporter 1 hsa05034 NA
127 MAP4K3 Q8IVH8 Mitogen-activated protein kinase kinase kinase kinase 3 hsa04010 5J5T
128 WEE1 P30291 Wee1-like protein kinase hsa04110; hsa05170 1X8B; 2IN6; 2IO6; 2Z2W; 3BI6; 3BIZ; 3CQE; 3CR0
129 STK38L Q9Y2H1 Serine/threonine-protein kinase 38-like NA NA
130 ICK Q9UPZ9 Serine/threonine-protein kinase ICK NA NA
131 MARK4 Q96L34 MAP/microtubule affinity-regulating kinase 4 NA 5ES1
132 BMX P51813 Cytoplasmic tyrosine-protein kinase BMX NA 2EKX; 2YS2; 3SXR; 3SXS
133 PRKAB2 O43741 5'-AMP-activated protein kinase subunit beta-2 hsa04068; hsa04152; hsa04211; hsa04213; hsa04371; hsa04530; hsa04710; hsa04714; hsa04910; hsa04920; hsa04921; hsa04922; hsa04931; hsa04932; hsa05410 2F15; 2V8Q; 2V92; 2V9J; 2Y8L; 2Y8Q; 2YA3; 4CFH; 4EAI; 4EAJ; 4RER; 4REW
134 PAK4 O96013 Serine/threonine-protein kinase PAK 4 hsa04012; hsa04014; hsa04360; hsa04510; hsa04660; hsa04810; hsa05170; hsa05206; hsa05211
135 TAOK3 Q9H2K8 Serine/threonine-protein kinase TAO3 hsa04010 NA
136 PTK2B Q14289 Protein-tyrosine kinase 2-beta hsa04020; hsa04062; hsa04072; hsa04650; hsa04670; hsa04912; hsa05161; hsa05163; hsa05170 2FO6; 2LK4; 3CC6; 3ET7; 3FZO; 3FZP; 3FZR; 3FZS; 3FZT; 3GM1; 3GM2; 3GM3; 3H3C; 3U3F; 4EKU; 4H1J; 4H1M; 4R32
137 MATK P42679 Megakaryocyte-associated tyrosine-protein kinase hsa04722 1JWO; 1X6G; 3US4
138 ROS1 P08922 Proto-oncogene tyrosine-protein kinase ROS NA 3ZBF; 4UXL
139 TXK P42681 Tyrosine-protein kinase TXK hsa04670 2DM0
140 CDK17 Q00537 Cyclin-dependent kinase 17 NA NA
141 PTK2 Q05397 Focal adhesion kinase 1 hsa01522; hsa04012; hsa04062; hsa04151; hsa04360; hsa04370; hsa04510; hsa04670; hsa04810; hsa05100; hsa05146; hsa05163; hsa05165; hsa05170; hsa05200; hsa05202; hsa05205; hsa05222; hsa05418
142 SGK3 Q96BR1 Serine/threonine-protein kinase Sgk3 NA NA
143 EIF2AK2 P19525 Interferon-induced, double-stranded RNA-activated protein kinase hsa04141; hsa04217; hsa05160; hsa05162; hsa05164; hsa05165; hsa05167; hsa05168; hsa05169; hsa05203 1QU6; 2A19; 2A1A; 3UIU
144 DDR1 Q08345 Epithelial discoidin domain-containing receptor 1 NA 3ZOS; 4AG4; 4BKJ; 4CKR; 5BVK; 5BVN; 5BVO; 5BVW
145 LCK P06239 Tyrosine-protein kinase Lck hsa04064; hsa04380; hsa04650; hsa04658; hsa04659; hsa04660; hsa05166; hsa05340
146 MAPK10 P53779 Mitogen-activated protein kinase 10 hsa01522; hsa04010; hsa04012; hsa04014; hsa04024; hsa04068; hsa04071; hsa04137; hsa04140; hsa04141; hsa04210; hsa04215; hsa04217; hsa04310; hsa04380; hsa04510; hsa04530; hsa04620; hsa04621; hsa04622; hsa04625; hsa04657; hsa04658; hsa04659; hsa04664; hsa04668; hsa04722; hsa04723; hsa04728; hsa04750; hsa04910; hsa04912; hsa04914; hsa04917; hsa04920; hsa04926; hsa04930; hsa04931; hsa04932; hsa04933; hsa05120; hsa05131; hsa05132; hsa05133; hsa05142; hsa05145; hsa05152; hsa05160; hsa05161; hsa05164; hsa05167; hsa05168; hsa05169; hsa05170; hsa05200; hsa05210; hsa05212; hsa05231; hsa05418
147 HIPK3 Q9H422 Homeodomain-interacting protein kinase 3 hsa04218 NA
148 ERBB2 P04626 Receptor tyrosine-protein kinase erbB-2 hsa01521; hsa01522; hsa01524; hsa04010; hsa04012; hsa04020; hsa04066; hsa04151; hsa04510; hsa04520; hsa04530; hsa05200; hsa05205; hsa05206; hsa05212; hsa05213; hsa05215; hsa05219; hsa05223; hsa05224; hsa05226; hsa05230
149 LTK P29376 Leukocyte tyrosine kinase receptor NA NA
150 PIK3CG P48736 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform hsa00562; hsa04022; hsa04062; hsa04072; hsa04151; hsa04261; hsa04371; hsa04611; hsa04725; hsa04921; hsa05145; hsa05167
151 TAOK1 Q7L7X3 Serine/threonine-protein kinase TAO1 hsa04010 NA
152 PRKCG P05129 Protein kinase C gamma type hsa01521; hsa04010; hsa04012; hsa04014; hsa04015; hsa04020; hsa04066; hsa04070; hsa04071; hsa04150; hsa04270; hsa04310; hsa04370; hsa04510; hsa04540; hsa04650; hsa04666; hsa04670; hsa04713; hsa04720; hsa04723; hsa04724; hsa04725; hsa04726; hsa04727; hsa04728; hsa04730; hsa04750; hsa04911; hsa04916; hsa04918; hsa04919; hsa04921; hsa04925; hsa04928; hsa04960; hsa04961; hsa04970; hsa04971; hsa04972; hsa05031; hsa05032; hsa05143; hsa05146; hsa05161; hsa05163; hsa05170; hsa05200; hsa05205; hsa05206; hsa05214; hsa05223; hsa05225; hsa05231 2E73; 2UZP
153 EIF2AK4 Q9P2K8 eIF-2-alpha kinase GCN2 hsa04140; hsa04141; hsa05160; hsa05162; hsa05164; hsa05168; hsa05169 NA
154 MAST1 Q9Y2H9 Microtubule-associated serine/threonine-protein kinase 1 NA 2M9X; 3PS4
155 TSSK1B Q9BXA7 Testis-specific serine/threonine-protein kinase 1 NA NA
156 PLK1 P53350 Serine/threonine-protein kinase PLK1 hsa04068; hsa04110; hsa04114; hsa04914
157 MAP2K6 P52564 Dual specificity mitogen-activated protein kinase kinase 6 hsa04010; hsa04015; hsa04218; hsa04380; hsa04620; hsa04664; hsa04668; hsa04750; hsa04912; hsa05014; hsa05145; hsa05163; hsa05164; hsa05167; hsa05169; hsa05170; hsa05418 2Y8O; 3ENM; 3FME; 3VN9; 5ETF
158 PAK5 Q9P286 Serine/threonine-protein kinase PAK 5 hsa04012; hsa04014; hsa04360; hsa04510; hsa04660; hsa04810; hsa05170; hsa05211 2F57
159 PKN1 Q16512 Serine/threonine-protein kinase N1 hsa04151; hsa05132 1CXZ; 1URF; 2RMK; 4NKG; 4OTD; 4OTG; 4OTH; 4OTI
160 ABL2 P42684 Abelson tyrosine-protein kinase 2 hsa04012; hsa04014; hsa05416 2ECD; 2KK1; 2XYN; 3GVU; 3HMI; 3ULR; 4EIH
161 PRKACA P17612 cAMP-dependent protein kinase catalytic subunit alpha hsa01522; hsa04010; hsa04014; hsa04020; hsa04024; hsa04062; hsa04114; hsa04140; hsa04211; hsa04213; hsa04261; hsa04270; hsa04310; hsa04340; hsa04371; hsa04530; hsa04540; hsa04611; hsa04713; hsa04714; hsa04720; hsa04723; hsa04724; hsa04725; hsa04726; hsa04727; hsa04728; hsa04740; hsa04742; hsa04750; hsa04910; hsa04911; hsa04912; hsa04913; hsa04914; hsa04915; hsa04916; hsa04918; hsa04919; hsa04921; hsa04922; hsa04923; hsa04924; hsa04925; hsa04926; hsa04927; hsa04928; hsa04934; hsa04961; hsa04962; hsa04970; hsa04971; hsa04976; hsa05012; hsa05020; hsa05030; hsa05031; hsa05032; hsa05034; hsa05110; hsa05146; hsa05163; hsa05165; hsa05166; hsa05169; hsa05200; hsa05203; hsa05205; hsa05414
162 FGFR1 P11362 Fibroblast growth factor receptor 1 hsa04010; hsa04014; hsa04015; hsa04151; hsa04520; hsa04550; hsa04714; hsa04810; hsa04928; hsa05200; hsa05205; hsa05215; hsa05218; hsa05224; hsa05230
163 SBK3 P0C264 Uncharacterized serine/threonine-protein kinase SBK3 NA NA
164 ULK1 O75385 Serine/threonine-protein kinase ULK1 hsa04137; hsa04140; hsa04150; hsa04152; hsa04211 4WNO; 4WNP; 5CI7
165 PRKAA2 P54646 5'-AMP-activated protein kinase catalytic subunit alpha-2 hsa04068; hsa04140; hsa04150; hsa04151; hsa04152; hsa04211; hsa04213; hsa04371; hsa04530; hsa04710; hsa04714; hsa04910; hsa04920; hsa04921; hsa04922; hsa04931; hsa04932; hsa05410; hsa05418 2H6D; 2LTU; 2YZA; 3AQV; 4CFE; 4CFF
166 NEK2 P51955 Serine/threonine-protein kinase Nek2 NA
167 PI4KB Q9UBF8 Phosphatidylinositol 4-kinase beta hsa00562; hsa01100; hsa04070 2N73; 4D0L; 4D0M; 4WAE; 4WAG; 5C46; 5C4G; 5EUQ; 5FBL; 5FBQ; 5FBR; 5FBV; 5FBW; 5LX2; 5NAS
168 CSF1R P07333 Macrophage colony-stimulating factor 1 receptor hsa04010; hsa04014; hsa04015; hsa04060; hsa04151; hsa04380; hsa04640; hsa05200; hsa05202; hsa05221 2I0V; 2I0Y; 2I1M; 2OGV; 3BEA; 3DPK; 3KRJ; 3KRL; 3LCD; 3LCO; 4DKD; 4HW7; 4LIQ; 4R7H; 4R7I; 4WRL; 4WRM
169 PDPK1 O15530 3-phosphoinositide-dependent protein kinase 1 hsa01524; hsa03320; hsa04068; hsa04071; hsa04140; hsa04150; hsa04151; hsa04152; hsa04210; hsa04510; hsa04660; hsa04664; hsa04722; hsa04910; hsa04919; hsa04931; hsa04960; hsa05145; hsa05160; hsa05205; hsa05213; hsa05215; hsa05223; hsa05231
170 CTSS P25774 Cathepsin S hsa04142; hsa04145; hsa04210; hsa04612; hsa05152
171 MARK1 Q9P0L2 Serine/threonine-protein kinase MARK1 NA 2HAK; 3OSE
172 ZAP70 P43403 Tyrosine-protein kinase ZAP-70 hsa04014; hsa04064; hsa04650; hsa04658; hsa04659; hsa04660; hsa05340 1FBV; 1M61; 1U59; 2CBL; 2OQ1; 2OZO; 2Y1N; 3ZNI; 4A4B; 4A4C; 4K2R; 4XZ0; 4XZ1
173 CDK1 P06493 Cyclin-dependent kinase 1 hsa04110; hsa04114; hsa04115; hsa04218; hsa04540; hsa04914; hsa05168; hsa05169; hsa05170; hsa05203 1LC9; 4Y72; 4YC6
174 FGFR2 P21802 Fibroblast growth factor receptor 2 hsa01521; hsa04010; hsa04014; hsa04015; hsa04144; hsa04151; hsa04550; hsa04810; hsa05200; hsa05215; hsa05226; hsa05230
175 MAP3K9 P80192 Mitogen-activated protein kinase kinase kinase 9 NA 3DTC; 4UY9
176 EPHB4 P54760 Ephrin type-B receptor 4 hsa04360 2BBA; 2E7H; 2HLE; 2QKQ; 2VWU; 2VWV; 2VWW; 2VWX; 2VWY; 2VWZ; 2VX0; 2VX1; 2X9F; 2XVD; 2YN8; 3ZEW; 4AW5; 4BB4
177 AURKC Q9UQB9 Aurora kinase C NA NA
178 MAP2K3 P46734 Dual specificity mitogen-activated protein kinase kinase 3 hsa04010; hsa04015; hsa04218; hsa04620; hsa04664; hsa04668; hsa04714; hsa04750; hsa04912; hsa05014; hsa05145; hsa05164; hsa05169; hsa05170 NA
179 EPHA3 P29320 Ephrin type-A receptor 3 hsa04360
180 MELK Q14680 Maternal embryonic leucine zipper kinase NA
181 CHEK1 O14757 Serine/threonine-protein kinase Chk1 hsa04110; hsa04115; hsa04218; hsa05166; hsa05170; hsa05203
182 TYRO3 Q06418 Tyrosine-protein kinase receptor TYRO3 NA 1RHF
183 MAP3K11 Q16584 Mitogen-activated protein kinase kinase kinase 11 hsa04010; hsa04932 5K26; 5K28
184 PHKG1 Q16816 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform hsa04020; hsa04910; hsa04922 NA
185 COQ8A Q8NI60 Atypical kinase COQ8A, mitochondrial NA 4PED; 5I35
186 CDK15 Q96Q40 Cyclin-dependent kinase 15 NA NA
187 RET P07949 Proto-oncogene tyrosine-protein kinase receptor Ret hsa05200; hsa05216; hsa05230 1XPD; 2IVS; 2IVT; 2IVU; 2IVV; 2X2K; 2X2L; 2X2M; 2X2U; 4CKI; 4CKJ; 4UX8
188 MKNK2 Q9HBH9 MAP kinase-interacting serine/threonine-protein kinase 2 hsa04010; hsa04066; hsa04910 2AC3; 2AC5; 2HW7
189 PDGFRA P16234 Platelet-derived growth factor receptor alpha hsa01521; hsa04010; hsa04014; hsa04015; hsa04020; hsa04072; hsa04144; hsa04151; hsa04510; hsa04540; hsa04630; hsa04810; hsa05163; hsa05166; hsa05200; hsa05206; hsa05214; hsa05215; hsa05218; hsa05230; hsa05231 1GQ5
190 ULK3 Q6PHR2 Serine/threonine-protein kinase ULK3 NA 4WZX
191 PRKAG2 Q9UGJ0 5'-AMP-activated protein kinase subunit gamma-2 hsa04068; hsa04152; hsa04211; hsa04213; hsa04371; hsa04530; hsa04710; hsa04714; hsa04910; hsa04920; hsa04921; hsa04922; hsa04931; hsa04932; hsa05410 NA
192 NEK5 Q6P3R8 Serine/threonine-protein kinase Nek5 NA NA
193 ERBB4 Q15303 Receptor tyrosine-protein kinase erbB-4 hsa04010; hsa04012; hsa04020; hsa04151; hsa05205 2AHX; 2L2T; 2LCX; 2R4B; 3BBT; 3BBW; 3BCE; 3U2P; 3U7U; 3U9U
194 NTRK1 P04629 High affinity nerve growth factor receptor hsa04010; hsa04014; hsa04151; hsa04210; hsa04722; hsa04750; hsa05200; hsa05202; hsa05216; hsa05230 1HE7; 1SHC; 1WWA; 1WWW; 2IFG; 4AOJ; 4CRP; 4F0I; 4GT5; 4PMM; 4PMP; 4PMS; 4PMT; 4YNE; 4YPS
195 CLK3 P49761 Dual specificity protein kinase CLK3 NA 2EU9; 2EXE; 2WU6; 2WU7; 3RAW
196 PRKD1 Q15139 Serine/threonine-protein kinase D1 hsa04015; hsa04925 NA
197 FLT4 P35916 Vascular endothelial growth factor receptor 3 hsa04010; hsa04014; hsa04015; hsa04151; hsa04510; hsa05200; hsa05224 4BSJ; 4BSK
198 SYK P43405 Tyrosine-protein kinase SYK hsa04064; hsa04072; hsa04151; hsa04380; hsa04611; hsa04625; hsa04650; hsa04662; hsa04664; hsa04666; hsa05152; hsa05167; hsa05169; hsa05203
199 CTSL P07711 Cathepsin L1 hsa04140; hsa04142; hsa04145; hsa04210; hsa04612; hsa05205; hsa05323; hsa05418
200 EPHA1 P21709 Ephrin type-A receptor 1 hsa04360 2K1K; 2K1L; 3HIL; 3KKA
201 PRKCQ Q04759 Protein kinase C theta type hsa04064; hsa04140; hsa04270; hsa04658; hsa04659; hsa04660; hsa04750; hsa04920; hsa04931; hsa05162 1XJD; 2ENJ; 2ENN; 2ENZ; 2JED; 4Q9Z; 4RA5
202 FRK P42685 Tyrosine-protein kinase FRK NA NA
203 MAP3K10 Q02779 Mitogen-activated protein kinase kinase kinase 10 NA 2RF0
204 YES1 P07947 Tyrosine-protein kinase Yes hsa04520 2HDA
205 RPS6KA6 Q9UK32 Ribosomal protein S6 kinase alpha-6 hsa04010; hsa04114; hsa04150; hsa04714; hsa04720; hsa04722; hsa04914; hsa04931 NA
206 EPHA6 Q9UF33 Ephrin type-A receptor 6 hsa04360 NA
207 MKNK1 Q9BUB5 MAP kinase-interacting serine/threonine-protein kinase 1 hsa04010; hsa04066; hsa04910 2HW6; 2Y9Q
208 ULK2 Q8IYT8 Serine/threonine-protein kinase ULK2 hsa04136; hsa04140; hsa04150 NA
209 PRKAG1 P54619 5'-AMP-activated protein kinase subunit gamma-1 hsa04068; hsa04152; hsa04211; hsa04213; hsa04371; hsa04530; hsa04710; hsa04714; hsa04910; hsa04920; hsa04921; hsa04922; hsa04931; hsa04932; hsa05410 2UV4; 2UV5; 2UV6; 2UV7; 4CFE; 4CFF; 4RER; 4REW
210 MAP3K13 O43283 Mitogen-activated protein kinase kinase kinase 13 hsa04010 NA
211 NEK4 P51957 Serine/threonine-protein kinase Nek4 NA NA
212 STK24 Q9Y6E0 Serine/threonine-protein kinase 24 NA
213 BRAF P15056 Serine/threonine-protein kinase B-raf hsa01521; hsa01522; hsa04010; hsa04012; hsa04015; hsa04024; hsa04062; hsa04068; hsa04150; hsa04270; hsa04510; hsa04650; hsa04720; hsa04722; hsa04726; hsa04730; hsa04810; hsa04910; hsa04914; hsa04928; hsa04934; hsa05034; hsa05160; hsa05200; hsa05205; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05216; hsa05218; hsa05219; hsa05220; hsa05221; hsa05223; hsa05224; hsa05225; hsa05226
214 MYLK2 Q9H1R3 Myosin light chain kinase 2, skeletal/cardiac muscle hsa04020; hsa04022; hsa04270; hsa04371; hsa04510; hsa04611; hsa04810; hsa04921; hsa04971 2LV6; 3KF9
215 MAP3K19 Q56UN5 Mitogen-activated protein kinase kinase kinase 19 NA NA
216 PLK4 O00444 Serine/threonine-protein kinase PLK4 hsa04068 2N19; 3COK; 4JXF; 4N7V; 4N7Z; 4N9J; 4YUR; 4YYP; 5LHY; 5LHZ
217 AAK1 Q2M2I8 AP2-associated protein kinase 1 NA 4WSQ; 5L4Q; 5TE0
218 CSNK2A2 P19784 Casein kinase II subunit alpha' hsa03008; hsa04064; hsa04137; hsa04310; hsa04520; hsa05162; hsa05168; hsa05169 3E3B; 3OFM; 3U87
219 RIPK4 P57078 Receptor-interacting serine/threonine-protein kinase 4 NA NA
220 CAMKK2 Q96RR4 Calcium/calmodulin-dependent protein kinase kinase 2 hsa04140; hsa04152; hsa04211; hsa04920; hsa04921; hsa05034 2ZV2; 5UY6; 5UYJ; 5VT1; 6BKU; 6BLE; 6BQL; 6BQP; 6BQQ; 6BRC; 6EWW; 6FEL
221 ADORA3 P0DMS8 Adenosine receptor A3 hsa04022; hsa04071; hsa04080 1OEA; 1R7N
222 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 hsa05012 2ZEJ; 3D6T; 5MY9; 5MYC
223 PRPF4B Q13523 Serine/threonine-protein kinase PRP4 homolog NA 4IAN; 4IFC; 4IIR; 4IJP
224 CSNK2A1 P68400 Casein kinase II subunit alpha hsa03008; hsa04064; hsa04137; hsa04310; hsa04520; hsa05162; hsa05168; hsa05169
225 EPHA7 Q15375 Ephrin type-A receptor 7 hsa04360 2REI; 3DKO; 3H8M; 3NRU
226 CDK4 P11802 Cyclin-dependent kinase 4 hsa01522; hsa04110; hsa04115; hsa04151; hsa04218; hsa04530; hsa04660; hsa04933; hsa04934; hsa05161; hsa05162; hsa05163; hsa05165; hsa05166; hsa05167; hsa05200; hsa05203; hsa05212; hsa05214; hsa05218; hsa05219; hsa05220; hsa05222; hsa05223; hsa05224; hsa05225 1LD2; 2W96; 2W99; 2W9F; 2W9Z; 3G33
227 RAF1 P04049 RAF proto-oncogene serine/threonine-protein kinase hsa01521; hsa01522; hsa04010; hsa04012; hsa04014; hsa04015; hsa04022; hsa04024; hsa04062; hsa04068; hsa04071; hsa04072; hsa04140; hsa04150; hsa04151; hsa04210; hsa04218; hsa04270; hsa04360; hsa04370; hsa04371; hsa04510; hsa04540; hsa04550; hsa04625; hsa04630; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04720; hsa04722; hsa04726; hsa04730; hsa04810; hsa04910; hsa04912; hsa04914; hsa04915; hsa04916; hsa04917; hsa04919; hsa04921; hsa04926; hsa04928; hsa05034; hsa05152; hsa05160; hsa05161; hsa05163; hsa05164; hsa05165; hsa05167; hsa05170; hsa05200; hsa05205; hsa05206; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05219; hsa05220; hsa05221; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231 1C1Y; 1FAQ; 1FAR; 1GUA; 1RFA; 3CU8; 3IQJ; 3IQU; 3IQV; 3KUC; 3KUD; 3NKX; 3O8I; 3OMV; 4FJ3; 4G0N; 4G3X; 4IEA; 4IHL
228 PLK2 Q9NYY3 Serine/threonine-protein kinase PLK2 hsa04068 4I5M; 4I5P; 4I6B; 4I6F; 4I6H; 4RS6; 4XB0
229 AURKA O14965 Aurora kinase A hsa04114; hsa04914
230 EPHA4 P54764 Ephrin type-A receptor 4 hsa04360 2LW8; 2WO1; 2WO2; 2WO3; 3CKH; 3GXU; 4BK4; 4BK5; 4BKA; 4BKF; 4M4P; 4M4R; 4W4Z; 4W50; 5JR2
231 IRAK4 Q9NWZ3 Interleukin-1 receptor-associated kinase 4 hsa04010; hsa04064; hsa04620; hsa04621; hsa04722; hsa05133; hsa05140; hsa05142; hsa05145; hsa05152; hsa05162; hsa05164; hsa05170 2NRU; 2NRY; 2O8Y; 2OIB; 2OIC; 2OID; 3MOP; 4U97; 4U9A; 4XS2; 4Y73; 4YO6; 4YP8; 4ZTL; 4ZTM; 4ZTN
232 ERN1 O75460 Serine/threonine-protein kinase/endoribonuclease IRE1 hsa04140; hsa04141; hsa04210; hsa04932; hsa05010 2HZ6; 3P23; 4U6R; 4YZ9; 4YZC; 4YZD; 4Z7G; 4Z7H
233 JAK1 P23458 Tyrosine-protein kinase JAK1 hsa01521; hsa04151; hsa04217; hsa04380; hsa04550; hsa04621; hsa04630; hsa04658; hsa04659; hsa05140; hsa05145; hsa05152; hsa05160; hsa05161; hsa05162; hsa05163; hsa05164; hsa05165; hsa05166; hsa05167; hsa05168; hsa05169; hsa05200; hsa05203; hsa05212 3EYG; 3EYH; 4E4L; 4E4N; 4E5W; 4EHZ; 4EI4; 4FK6; 4GS0; 4I5C; 4IVB; 4IVC; 4IVD; 4K6Z; 4K77; 4L00; 4L01
234 MAPK14 Q16539 Mitogen-activated protein kinase 14 hsa01522; hsa04010; hsa04015; hsa04068; hsa04071; hsa04218; hsa04261; hsa04370; hsa04380; hsa04550; hsa04611; hsa04620; hsa04621; hsa04622; hsa04625; hsa04657; hsa04658; hsa04659; hsa04660; hsa04664; hsa04668; hsa04670; hsa04714; hsa04722; hsa04723; hsa04728; hsa04750; hsa04912; hsa04914; hsa04917; hsa04926; hsa04933; hsa05014; hsa05120; hsa05131; hsa05132; hsa05133; hsa05140; hsa05142; hsa05145; hsa05152; hsa05160; hsa05163; hsa05164; hsa05167; hsa05169; hsa05170; hsa05205; hsa05418
1A9U; 1BL6; 1BL7; 1BMK; 1DI9; 1IAN; 1KV1; 1KV2; 1M7Q; 1OUK; 1OUY; 1OVE; 1OZ1; 1R39; 1R3C; 1W7H; 1W82; 1W83; 1W84; 1WBN; 1WBO; 1WBS; 1WBT; 1WBV; 1WBW; 1WFC; 1YQJ; 1ZYJ; 1ZZ2; 1ZZL; 2BAJ; 2BAK; 2BAL; 2BAQ; 2FSL; 2FSM; 2FSO; 2FST; 2GFS; 2I0H; 2LGC; 2NPQ; 2OKR; 2ONL; 2QD9; 2RG5; 2RG6; 2Y8O; 2YIS; 2YIW; 2YIX; 2ZAZ; 2ZB0; 2ZB1; 3BV2; 3BV3; 3BX5; 3C5U; 3CTQ; 3D7Z; 3D83; 3DS6; 3DT1; 3E92; 3E93; 3FC1; 3FI4; 3FKL; 3FKN; 3FKO; 3FL4; 3FLN; 3FLQ; 3FLS; 3FLW; 3FLY; 3FLZ; 3FMH; 3FMJ; 3FMK; 3FML; 3FMM; 3FMN; 3FSF; 3FSK; 3GC7; 3GCP; 3GCQ; 3GCS; 3GCU; 3GCV; 3GFE; 3GI3; 3HA8; 3HEC; 3HEG; 3HL7; 3HLL; 3HP2; 3HP5; 3HRB; 3HUB; 3HUC; 3HV3; 3HV4; 3HV5; 3HV6; 3HV7; 3HVC; 3IPH; 3ITZ; 3IW5; 3IW6; 3IW7; 3IW8; 3K3I; 3K3J; 3KF7; 3KQ7; 3L8S; 3L8X; 3LFA; 3LFB; 3LFC; 3LFD; 3LFE; 3LFF; 3LHJ; 3MGY; 3MH0; 3MH1; 3MH2; 3MH3; 3MPA; 3MPT; 3MVL; 3MVM; 3MW1; 3NEW; 3NNU; 3NNV; 3NNW; 3NNX; 3NWW; 3O8P; 3O8T; 3O8U; 3OBG; 3OBJ; 3OC1; 3OCG; 3OD6; 3ODY; 3ODZ; 3OEF; 3PG3; 3QUD; 3QUE; 3RIN; 3ROC; 3S3I; 3S4Q; 3U8W; 3UVP; 3UVQ; 3UVR; 3ZS5; 3ZSG; 3ZSH; 3ZSI; 3ZYA; 4A9Y; 4AA0; 4AA4; 4AA5; 4AAC; 4DLI; 4DLJ; 4E5A; 4E5B; 4E6A; 4E6C; 4E8A; 4EH2; 4EH3; 4EH4; 4EH5; 4EH6; 4EH7; 4EH8; 4EH9; 4EHV; 4EWQ; 4F9W; 4F9Y; 4FA2; 4GEO; 4KIN; 4KIP; 4KIQ; 4L8M; 4R3C
235 MAP3K12 Q12852 Mitogen-activated protein kinase kinase kinase 12 hsa04010 5CEN; 5CEO; 5CEP; 5CEQ; 5VO1; 5VO2
236 NIM1K Q8IY84 Serine/threonine-protein kinase NIM1 NA NA
237 EPHB1 P54762 Ephrin type-B receptor 1 hsa04360 2DJS; 2EAO; 3ZFX; 5MJA; 5MJB
238 MAP4K5 Q9Y4K4 Mitogen-activated protein kinase kinase kinase kinase 5 NA NA
239 DDR2 Q16832 Discoidin domain-containing receptor 2 NA 2WUH; 2Z4F
240 PRKAG3 Q9UGI9 5'-AMP-activated protein kinase subunit gamma-3 hsa04068; hsa04152; hsa04211; hsa04213; hsa04371; hsa04530; hsa04710; hsa04714; hsa04910; hsa04920; hsa04921; hsa04922; hsa04931; hsa04932; hsa05410 NA
241 INSRR P14616 Insulin receptor-related protein hsa04810; hsa05215 NA
242 NEK9 Q8TD19 Serine/threonine-protein kinase Nek9 NA 3ZKE; 3ZKF
243 TEC P42680 Tyrosine-protein kinase Tec hsa04380; hsa04660 2LUL
244 CAMKK1 Q8N5S9 Calcium/calmodulin-dependent protein kinase kinase 1 hsa05034 6CCF; 6CD6
245 MAP3K2 Q9Y2U5 Mitogen-activated protein kinase kinase kinase 2 hsa04010; hsa04540; hsa04912 2CU1; 2NPT
246 PRKG2 Q13237 cGMP-dependent protein kinase 2 hsa04022; hsa04540; hsa04611; hsa04713; hsa04714; hsa04730; hsa04740; hsa04923; hsa04924; hsa04970 5BV6; 5C6C; 5C8W; 5JIX; 5JIZ
247 TESK1 Q15569 Dual specificity testis-specific protein kinase 1 NA NA
248 NUAK2 Q9H093 NUAK family SNF1-like kinase 2 NA NA
249 CDC42BPG Q6DT37 Serine/threonine-protein kinase MRCK gamma NA NA
250 RIOK2 Q9BVS4 Serine/threonine-protein kinase RIO2 hsa03008 5DHF
251 NTRK2 Q16620 BDNF/NT-3 growth factors receptor hsa04010; hsa04014; hsa04151; hsa04722; hsa05034 1HCF; 1WWB; 2MFQ; 4ASZ; 4AT3; 4AT4; 4AT5
252 PRKCD Q05655 Protein kinase C delta type hsa04062; hsa04140; hsa04270; hsa04621; hsa04625; hsa04666; hsa04722; hsa04750; hsa04912; hsa04915; hsa04930; hsa04931; hsa04933 1YRK; 2YUU
253 SNRK Q9NRH2 SNF-related serine/threonine-protein kinase NA 5YKS
254 EPHA5 P54756 Ephrin type-A receptor 5 hsa04360 2R2P; 4ET7
255 EPHA8 P29322 Ephrin type-A receptor 8 hsa04360 1UCV; 1X5L; 3KUL
256 JAK3 P52333 Tyrosine-protein kinase JAK3 hsa04062; hsa04151; hsa04217; hsa04550; hsa04630; hsa04658; hsa04659; hsa05162; hsa05166; hsa05169; hsa05200; hsa05203; hsa05223; hsa05340 1YVJ; 3LXK; 3LXL; 3PJC; 3ZC6; 3ZEP; 4HVD; 4HVG; 4HVH; 4HVI; 4I6Q; 4QPS; 4QT1; 4RIO
257 MERTK Q12866 Tyrosine-protein kinase Mer NA 2DBJ; 2P0C; 3BPR; 3BRB; 3TCP; 4M3Q; 4MH7; 4MHA
258 IKBKE Q14164 Inhibitor of nuclear factor kappa-B kinase subunit epsilon hsa04620; hsa04621; hsa04622; hsa04623; hsa04625; hsa04657; hsa05160; hsa05161; hsa05162; hsa05164; hsa05165; hsa05167; hsa05168 NA
259 MAP3K1 Q13233 Mitogen-activated protein kinase kinase kinase 1 hsa04010; hsa04120; hsa04530; hsa04622; hsa04722; hsa04912; hsa05161; hsa05166 NA
260 DAPK2 Q9UIK4 Death-associated protein kinase 2 hsa04140; hsa05200; hsa05219 1WMK; 1WRZ; 1Z9X; 1ZUZ; 1ZWS; 2A27; 2A2A; 2CKE
261 CSNK1A1 P48729 Casein kinase I isoform alpha hsa04310; hsa04340; hsa05165; hsa05224; hsa05225; hsa05226 5FQD
262 UGT1A1 P22309 UDP-glucuronosyltransferase 1-1 hsa00040; hsa00053; hsa00140; hsa00830; hsa00860; hsa00980; hsa00982; hsa00983; hsa01100; hsa05204 NA
263 HCK P08631 Tyrosine-protein kinase HCK hsa04062; hsa04666; hsa05167
264 TBK1 Q9UHD2 Serine/threonine-protein kinase TBK1 hsa04014; hsa04137; hsa04620; hsa04621; hsa04622; hsa04623; hsa04657; hsa05160; hsa05161; hsa05162; hsa05163; hsa05164; hsa05165; hsa05167; hsa05168; hsa05169; hsa05170 4EFO; 4EUT; 4EUU; 4IM0; 4IM2; 4IM3; 4IW0; 4IWO; 4IWP; 4IWQ; 5EOA; 5EOF; 5EP6
265 PRKACB P22694 cAMP-dependent protein kinase catalytic subunit beta hsa01522; hsa04010; hsa04014; hsa04020; hsa04024; hsa04062; hsa04114; hsa04140; hsa04211; hsa04213; hsa04261; hsa04270; hsa04310; hsa04340; hsa04371; hsa04530; hsa04540; hsa04611; hsa04713; hsa04714; hsa04720; hsa04723; hsa04724; hsa04725; hsa04726; hsa04727; hsa04728; hsa04740; hsa04742; hsa04750; hsa04910; hsa04911; hsa04912; hsa04913; hsa04914; hsa04915; hsa04916; hsa04918; hsa04919; hsa04921; hsa04922; hsa04923; hsa04924; hsa04925; hsa04926; hsa04927; hsa04928; hsa04934; hsa04961; hsa04962; hsa04970; hsa04971; hsa04976; hsa05012; hsa05020; hsa05030; hsa05031; hsa05032; hsa05110; hsa05146; hsa05163; hsa05165; hsa05166; hsa05169; hsa05200; hsa05203; hsa05205; hsa05414 NA
266 EGFR P00533 Epidermal growth factor receptor hsa01521; hsa01522; hsa04010; hsa04012; hsa04014; hsa04015; hsa04020; hsa04066; hsa04068; hsa04072; hsa04144; hsa04151; hsa04510; hsa04520; hsa04540; hsa04630; hsa04810; hsa04912; hsa04915; hsa04921; hsa04926; hsa04928; hsa04934; hsa05120; hsa05160; hsa05163; hsa05165; hsa05200; hsa05205; hsa05206; hsa05210; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05219; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231
267 NUAK1 O60285 NUAK family SNF1-like kinase 1 NA NA
268 TGFBR2 P37173 TGF-beta receptor type-2 hsa04010; hsa04060; hsa04068; hsa04144; hsa04218; hsa04350; hsa04380; hsa04390; hsa04520; hsa04659; hsa04926; hsa04933; hsa05142; hsa05166; hsa05200; hsa05202; hsa05210; hsa05212; hsa05220; hsa05225; hsa05226 1KTZ; 1M9Z; 1PLO; 2PJY; 3KFD; 4P7U; 4XJJ
269 CAMK2G Q13555 Calcium/calmodulin-dependent protein kinase type II subunit gamma hsa04012; hsa04020; hsa04024; hsa04066; hsa04114; hsa04217; hsa04261; hsa04310; hsa04360; hsa04713; hsa04720; hsa04722; hsa04725; hsa04728; hsa04740; hsa04750; hsa04911; hsa04912; hsa04916; hsa04921; hsa04922; hsa04925; hsa04934; hsa04971; hsa05031; hsa05152; hsa05200; hsa05205; hsa05214 2UX0; 2V7O
270 RIOK1 Q9BRS2 Serine/threonine-protein kinase RIO1 hsa03008 4OTP
271 TLK1 Q9UKI8 Serine/threonine-protein kinase tousled-like 1 NA NA
272 KIT P10721 Mast/stem cell growth factor receptor Kit hsa04010; hsa04014; hsa04015; hsa04072; hsa04151; hsa04640; hsa04916; hsa05200; hsa05221; hsa05224; hsa05230 1PKG; 1QZJ; 1QZK; 1R01; 1T45; 1T46; 2E9W; 2EC8; 2VIF; 3G0E; 3G0F; 4HVS; 4K94; 4K9E; 4PGZ; 4U0I
273 DAPK3 O43293 Death-associated protein kinase 3 hsa04140; hsa05200; hsa05219 1YRP; 2J90; 3BHY; 3BQR; 5A6N; 5A6O
274 PAK1 Q13153 Serine/threonine-protein kinase PAK 1 hsa04010; hsa04012; hsa04014; hsa04024; hsa04062; hsa04360; hsa04392; hsa04510; hsa04625; hsa04650; hsa04660; hsa04666; hsa04810; hsa05120; hsa05170; hsa05205; hsa05211
275 SIK2 Q9H0K1 Serine/threonine-protein kinase SIK2 hsa04922 NA
276 CDKL2 Q92772 Cyclin-dependent kinase-like 2 NA 4AAA; 4BBM
277 PIK3C2G O75747 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma hsa00562; hsa01100; hsa04070 2WWE
278 TTK P33981 Dual specificity protein kinase TTK hsa04110
279 STK10 O94804 Serine/threonine-protein kinase 10 hsa04914 2J7T; 4AOT; 4BC6; 4EQU; 4USD; 4USE; 5AJQ; 5OWQ; 5OWR; 6EIM
280 PIM1 P11309 Serine/threonine-protein kinase pim-1 hsa04630; hsa04933; hsa05200; hsa05206; hsa05221
281 PIK3CD O00329 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform hsa00562; hsa01521; hsa01522; hsa01524; hsa04012; hsa04014; hsa04015; hsa04024; hsa04062; hsa04066; hsa04068; hsa04070; hsa04071; hsa04072; hsa04140; hsa04150; hsa04151; hsa04152; hsa04210; hsa04211; hsa04213; hsa04218; hsa04360; hsa04370; hsa04380; hsa04510; hsa04550; hsa04611; hsa04620; hsa04625; hsa04630; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04668; hsa04670; hsa04722; hsa04725; hsa04750; hsa04810; hsa04910; hsa04914; hsa04915; hsa04917; hsa04919; hsa04923; hsa04926; hsa04930; hsa04931; hsa04932; hsa04933; hsa04960; hsa04973; hsa05100; hsa05142; hsa05146; hsa05160; hsa05161; hsa05162; hsa05163; hsa05164; hsa05165; hsa05166; hsa05167; hsa05169; hsa05170; hsa05200; hsa05203; hsa05205; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05220; hsa05221; hsa05222; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231; hsa05418 NA
282 CLK4 Q9HAZ1 Dual specificity protein kinase CLK4 NA NA
283 COQ8B Q96D53 Atypical kinase COQ8B, mitochondrial NA NA
284 RPS6KA1 Q15418 Ribosomal protein S6 kinase alpha-1 hsa04010; hsa04114; hsa04150; hsa04714; hsa04720; hsa04722; hsa04914; hsa04931 2WNT; 2Z7Q; 2Z7R; 2Z7S; 3RNY; 3TEI; 4H3P; 4NIF; 5CSF; 5CSI; 5CSJ; 5CSN
285 CASK O14936 Peripheral plasma membrane protein CASK NA 1KGD; 1KWA; 1ZL8; 3C0G; 3C0H; 3C0I; 3MFR; 3MFS; 3MFT; 3MFU; 3TAC
286 IRAK1 P51617 Interleukin-1 receptor-associated kinase 1 hsa04010; hsa04064; hsa04620; hsa04722; hsa05133; hsa05140; hsa05142; hsa05145; hsa05152; hsa05162; hsa05169; hsa05170 6BFN
287 BTK Q06187 Tyrosine-protein kinase BTK hsa04064; hsa04380; hsa04611; hsa04662; hsa04664; hsa05340
288 DCLK1 O15075 Serine/threonine-protein kinase DCLK1 NA 1MFW; 1MG4; 1UF0; 5JZJ; 5JZN
289 MAPKAPK5 Q8IW41 MAP kinase-activated protein kinase 5 hsa04010 NA
290 ITK Q08881 Tyrosine-protein kinase ITK/TSK hsa04062; hsa04660; hsa04670
291 TIE1 P35590 Tyrosine-protein kinase receptor Tie-1 NA 5N06
292 LATS1 O95835 Serine/threonine-protein kinase LATS1 hsa04390; hsa04392 4ZRK; 5B5W; 5BRK
293 OXSR1 O95747 Serine/threonine-protein kinase OSR1 NA 2V3S; 2VWI; 3DAK
294 PRKAA1 Q13131 5'-AMP-activated protein kinase catalytic subunit alpha-1 hsa04068; hsa04140; hsa04150; hsa04151; hsa04152; hsa04211; hsa04213; hsa04371; hsa04530; hsa04710; hsa04714; hsa04910; hsa04920; hsa04921; hsa04922; hsa04931; hsa04932; hsa05410; hsa05418 4RED; 4RER; 4REW
295 EPHB2 P29323 Ephrin type-B receptor 2 hsa04360 1B4F; 1F0M; 2QBX; 3ZFM
296 MARK3 P27448 MAP/microtubule affinity-regulating kinase 3 NA 2QNJ; 3FE3
297 PDGFRB P09619 Platelet-derived growth factor receptor beta hsa01521; hsa04010; hsa04014; hsa04015; hsa04020; hsa04072; hsa04151; hsa04510; hsa04540; hsa04630; hsa04810; hsa05165; hsa05166; hsa05200; hsa05206; hsa05214; hsa05215; hsa05218; hsa05230; hsa05231 1GQ5; 1H9O; 1LWP; 1SHA; 2L6W; 2PLD; 2PLE; 3MJG
298 PIK3C2B O00750 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta hsa00562; hsa01100; hsa04070 NA
299 TNIK Q9UKE5 TRAF2 and NCK-interacting protein kinase NA 2X7F; 5AX9; 5CWZ; 5D7A
300 KDR P35968 Vascular endothelial growth factor receptor 2 hsa01521; hsa04010; hsa04014; hsa04015; hsa04151; hsa04370; hsa04510; hsa05205; hsa05418
301 MUSK O15146 Muscle, skeletal receptor tyrosine-protein kinase NA NA
302 SRMS Q9H3Y6 Tyrosine-protein kinase Srms NA NA
303 CLK2 P49760 Dual specificity protein kinase CLK2 NA 3NR9


20 predicted interactions (targets) of input drug (DB12010): Fostamatinib
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 BCR P11274 Breakpoint cluster region protein hsa05200; hsa05220 1K1F; 2AIN 65.4%
2 MAPK11 Q15759 Mitogen-activated protein kinase 11 hsa01522; hsa04010; hsa04015; hsa04068; hsa04071; hsa04218; hsa04261; hsa04370; hsa04380; hsa04550; hsa04611; hsa04620; hsa04621; hsa04622; hsa04625; hsa04657; hsa04658; hsa04659; hsa04660; hsa04664; hsa04668; hsa04670; hsa04714; hsa04722; hsa04723; hsa04728; hsa04750; hsa04912; hsa04914; hsa04917; hsa04926; hsa04933; hsa05014; hsa05120; hsa05131; hsa05132; hsa05133; hsa05140; hsa05142; hsa05145; hsa05152; hsa05160; hsa05163; hsa05164; hsa05167; hsa05169; hsa05170; hsa05205; hsa05418 3GC8; 3GC9; 3GP0 63.0%
3 FGFR4 P22455 Fibroblast growth factor receptor 4 hsa04010; hsa04014; hsa04015; hsa04144; hsa04151; hsa04550; hsa04810; hsa05200 1QCT; 4QQ5; 4QQC; 4QQJ; 4QQT; 4QRC; 4R6V; 4TYE; 4TYG; 4TYI; 4TYJ; 4UXQ; 4XCU 62.7%
4 HRH1 P35367 Histamine H1 receptor hsa04020; hsa04080; hsa04750 3RZE 62.4%
5 F2 P00734 Prothrombin hsa04080; hsa04610; hsa04810
1A2C; 1A3B; 1A3E; 1A46; 1A4W; 1A5G; 1A61; 1ABI; 1ABJ; 1AD8; 1AE8; 1AFE; 1AHT; 1AI8; 1AIX; 1AWF; 1AWH; 1AY6; 1B5G; 1B7X; 1BA8; 1BB0; 1BCU; 1BHX; 1BMM; 1BMN; 1BTH; 1C1U; 1C1V; 1C1W; 1C4U; 1C4V; 1C4Y; 1C5L; 1C5N; 1C5O; 1CA8; 1D3D; 1D3P; 1D3Q; 1D3T; 1D4P; 1D6W; 1D9I; 1DE7; 1DIT; 1DM4; 1DOJ; 1DWB; 1DWC; 1DWD; 1DWE; 1DX5; 1E0F; 1EB1; 1EOJ; 1EOL; 1FPC; 1FPH; 1G30; 1G32; 1G37; 1GHV; 1GHW; 1GHX; 1GHY; 1GJ4; 1GJ5; 1H8D; 1H8I; 1HAG; 1HAH; 1HAI; 1HAO; 1HAP; 1HBT; 1HDT; 1HGT; 1HLT; 1HUT; 1HXE; 1HXF; 1IHS; 1IHT; 1JMO; 1JOU; 1JWT; 1K21; 1K22; 1KTS; 1KTT; 1LHC; 1LHD; 1LHE; 1LHF; 1LHG; 1MH0; 1MU6; 1MU8; 1MUE; 1NM6; 1NO9; 1NRN; 1NRO; 1NRP; 1NRQ; 1NRR; 1NRS; 1NT1; 1NU7; 1NU9; 1NY2; 1NZQ; 1O0D; 1O2G; 1O5G; 1OOK; 1OYT; 1P8V; 1PPB; 1QBV; 1QHR; 1QJ1; 1QJ6; 1QJ7; 1QUR; 1RD3; 1RIW; 1SB1; 1SFQ; 1SG8; 1SGI; 1SHH; 1SL3; 1SR5; 1T4U; 1T4V; 1TA2; 1TA6; 1TB6; 1TBZ; 1THP; 1THR; 1THS; 1TMB; 1TMT; 1TMU; 1TOM; 1TQ0; 1TQ7; 1TWX; 1UMA; 1UVS; 1VR1; 1VZQ; 1W7G; 1WAY; 1WBG; 1XM1; 1XMN; 1YPE; 1YPG; 1YPJ; 1YPK; 1YPL; 1YPM; 1Z71; 1Z8I; 1Z8J; 1ZGI; 1ZGV; 1ZRB; 2A0Q; 2A2X; 2A45; 2AFQ; 2ANK; 2ANM; 2B5T; 2BDY; 2BVR; 2BVS; 2BVX; 2BXT; 2BXU; 2C8W; 2C8X; 2C8Y; 2C8Z; 2C90; 2C93; 2CF8; 2CF9; 2CN0; 2FEQ; 2FES; 2GDE; 2GP9; 2H9T; 2HGT; 2HNT; 2HPP; 2HPQ; 2HWL; 2JH0; 2JH5; 2JH6; 2OD3; 2PGB; 2PGQ; 2PKS; 2PW8; 2R2M; 2THF; 2UUF; 2UUJ; 2UUK; 2V3H; 2V3O; 2ZC9; 2ZDA; 2ZDV; 2ZF0; 2ZFF; 2ZFP; 2ZFQ; 2ZFR; 2ZG0; 2ZGB; 2ZGX; 2ZHE; 2ZHF; 2ZHQ; 2ZHW; 2ZI2; 2ZIQ; 2ZNK; 2ZO3; 3B23; 3B9F; 3BEF; 3BEI; 3BF6; 3BIU; 3BIV; 3BV9; 3C1K; 3C27; 3D49; 3DA9; 3DD2; 3DHK; 3DT0; 3DUX; 3E6P; 3EE0; 3EGK; 3EQ0; 3F68; 3GIC; 3GIS; 3HAT; 3HKJ; 3HTC; 3JZ1; 3JZ2; 3K65; 3LDX; 3LU9; 3NXP; 3P17; 3P6Z; 3P70; 3PMH; 3PO1; 3QDZ; 3QGN; 3QLP; 3QTO; 3QTV; 3QWC; 3QX5; 3R3G; 3RLW; 3RLY; 3RM0; 3RM2; 3RML; 3RMM; 3RMN; 3RMO; 3S7H; 3S7K; 3SHA; 3SHC; 3SI3; 3SI4; 3SQE; 3SQH; 3SV2; 3T5F; 3TU7; 3U69; 3U8O; 3U8R; 3U8T; 3U98; 3U9A; 3UTU; 3UWJ; 3VXE; 3VXF; 4AX9; 4AYV; 4AYY; 4AZ2; 4BAH; 4BAK; 4BAM; 4BAN; 4BAO; 4BAQ; 4BOH; 4CH2; 4CH8; 4DIH; 4DII; 4DT7; 4DY7; 4E05; 4E06; 4E7R; 4H6S; 4H6T; 4HFP; 4HTC; 4HZH; 4I7Y; 4LOY; 4LXB; 4LZ1; 4LZ4; 4MLF; 4N3L; 4NZE; 4NZQ; 4O03; 4RKJ; 4RKO; 4RN6; 4THN; 4UD9; 4UDW; 4UE7; 4UEH; 4YES; 5AF9; 5AFY; 5AFZ; 5AHG; 5E8E; 5GDS; 7KME; 8KME
 53.5%
6 DPP4 P27487 Dipeptidyl peptidase 4 hsa04974 51.2%
7 NR4A3 Q92570 Nuclear receptor subfamily 4 group A member 3 hsa05202 NA 51.1%
8 LTA4H P09960 Leukotriene A-4 hydrolase hsa00590; hsa01100 50.3%
9 RET O43519 RET proto-oncogene NA NA 49.7%
10 PTGDR2 Q9Y5Y4 Prostaglandin D2 receptor 2 NA NA 45.7%
11 CSF2RA P15509 Granulocyte-macrophage colony-stimulating factor receptor subunit alpha hsa04060; hsa04630; hsa04640; hsa05200 4NKQ; 4RS1 45.5%
12 BACE1 P56817 Beta-secretase 1 hsa05010
1FKN; 1M4H; 1PY1; 1SGZ; 1TQF; 1UJJ; 1UJK; 1W50; 1W51; 1XN2; 1XN3; 1XS7; 1YM2; 1YM4; 2B8L; 2B8V; 2F3E; 2F3F; 2FDP; 2G94; 2HIZ; 2HM1; 2IQG; 2IRZ; 2IS0; 2NTR; 2OAH; 2OF0; 2OHK; 2OHL; 2OHM; 2OHN; 2OHP; 2OHQ; 2OHR; 2OHS; 2OHT; 2OHU; 2P4J; 2P83; 2P8H; 2PH6; 2PH8; 2Q11; 2Q15; 2QK5; 2QMD; 2QMF; 2QMG; 2QP8; 2QU2; 2QU3; 2QZK; 2QZL; 2VA5; 2VA6; 2VA7; 2VIE; 2VIJ; 2VIY; 2VIZ; 2VJ6; 2VJ7; 2VJ9; 2VKM; 2VNM; 2VNN; 2WEZ; 2WF0; 2WF1; 2WF2; 2WF3; 2WF4; 2WJO; 2XFI; 2XFJ; 2XFK; 2ZDZ; 2ZE1; 2ZHR; 2ZHS; 2ZHT; 2ZHU; 2ZHV; 2ZJH; 2ZJI; 2ZJJ; 2ZJK; 2ZJL; 2ZJM; 2ZJN; 3BRA; 3BUF; 3BUG; 3BUH; 3CIB; 3CIC; 3CID; 3CKP; 3CKR; 3DM6; 3DUY; 3DV1; 3DV5; 3EXO; 3FKT; 3H0B; 3HVG; 3HW1; 3I25; 3IGB; 3IN3; 3IN4; 3IND; 3INE; 3INF; 3INH; 3IVH; 3IVI; 3IXJ; 3IXK; 3K5C; 3K5D; 3K5F; 3K5G; 3KMX; 3KMY; 3KN0; 3KYR; 3L38; 3L3A; 3L58; 3L59; 3L5B; 3L5C; 3L5D; 3L5E; 3L5F; 3LHG; 3LNK; 3LPI; 3LPJ; 3LPK; 3MSJ; 3MSK; 3MSL; 3N4L; 3NSH; 3OHF; 3OHH; 3OOZ; 3PI5; 3QBH; 3QI1; 3R1G; 3R2F; 3RSV; 3RSX; 3RTH; 3RTM; 3RTN; 3RU1; 3RVI; 3S2O; 3S7L; 3S7M; 3SKF; 3SKG; 3TPJ; 3TPL; 3TPP; 3TPR; 3U6A; 3UDH; 3UDJ; 3UDK; 3UDM; 3UDN; 3UDP; 3UDQ; 3UDR; 3UDY; 3UFL; 3UQP; 3UQR; 3UQU; 3UQW; 3UQX; 3VEU; 3VF3; 3VG1; 3VV6; 3VV7; 3VV8; 3WB4; 3WB5; 3ZMG; 3ZOV; 4ACU; 4ACX; 4AZY; 4B00; 4B05; 4B0Q; 4B1C; 4B1D; 4B1E; 4B70; 4B72; 4B77; 4B78; 4BEK; 4BFD; 4D83; 4D85; 4D88; 4D89; 4D8C; 4DH6; 4DI2; 4DJU; 4DJV; 4DJW; 4DJX; 4DJY; 4DPF; 4DPI; 4DUS; 4DV9; 4DVF; 4EWO; 4EXG; 4FCO; 4FGX; 4FM7; 4FM8; 4FRI; 4FRJ; 4FRK; 4FRS; 4FS4; 4FSE; 4FSL; 4GID; 4GMI; 4H1E; 4H3F; 4H3G; 4H3I; 4H3J; 4HA5; 4HZT; 4I0D; 4I0E; 4I0F; 4I0G; 4I0H; 4I0I; 4I0J; 4I0Z; 4I10; 4I11; 4I12; 4I1C; 4IVS; 4IVT; 4J0P; 4J0T; 4J0V; 4J0Y; 4J0Z; 4J17; 4J1C; 4J1E; 4J1F; 4J1H; 4J1I; 4J1K; 4JOO; 4JP9; 4JPC; 4JPE; 4K8S; 4K9H; 4KE0; 4KE1; 4L7G; 4L7H; 4L7J; 4LC7; 4LXA; 4LXK; 4LXM; 4N00; 4PZW; 4PZX; 4R5N; 4R8Y; 4R91; 4R92; 4R93; 4R95; 4RCD; 4RCE; 4RCF; 4RRN; 4RRO; 4RRS; 4TRW; 4TRY; 4TRZ; 4WTU; 4WY1; 4WY6; 4X2L; 4X7I; 4XKX; 4XXS; 4YBI; 4ZPE; 4ZPF; 4ZPG; 4ZSM; 4ZSP; 4ZSQ; 4ZSR; 5CLM
 45.1%
13 PTGS2 P35354 Prostaglandin G/H synthase 2 hsa00590; hsa01100; hsa04064; hsa04370; hsa04625; hsa04657; hsa04668; hsa04723; hsa04726; hsa04913; hsa04921; hsa04923; hsa05140; hsa05163; hsa05165; hsa05167; hsa05200; hsa05204; hsa05206; hsa05222 1V0X 45.1%
14 PAH P00439 Phenylalanine-4-hydroxylase hsa00360; hsa00400; hsa00790; hsa01100; hsa01230 1DMW; 1J8T; 1J8U; 1KW0; 1LRM; 1MMK; 1MMT; 1PAH; 1TDW; 1TG2; 2PAH; 3PAH; 4ANP; 4PAH; 5PAH; 6PAH 44.8%
15 ACHE P22303 Acetylcholinesterase hsa00564; hsa04725 1B41; 1F8U; 1PUV; 1PUW; 1VZJ; 2CLJ; 2X8B; 3LII; 4BDT; 4EY4; 4EY5; 4EY6; 4EY7; 4EY8; 4M0E; 4M0F; 4PQE 42.4%
16 HSPA8 P11142 Heat shock cognate 71 kDa protein hsa03040; hsa04010; hsa04141; hsa04144; hsa04213; hsa04612; hsa04915; hsa05134; hsa05145; hsa05162; hsa05164; hsa05169 3AGY; 3AGZ; 3ESK; 3FZF; 3FZH; 3FZK; 3FZL; 3FZM; 3LDQ; 3M3Z; 4H5N; 4H5R; 4H5T; 4H5V; 4H5W; 4HWI; 4KBQ 41.2%
17 PRKCB P05771 Protein kinase C beta type hsa01521; hsa04010; hsa04012; hsa04014; hsa04015; hsa04020; hsa04062; hsa04064; hsa04066; hsa04070; hsa04071; hsa04150; hsa04270; hsa04310; hsa04370; hsa04510; hsa04540; hsa04650; hsa04662; hsa04666; hsa04670; hsa04713; hsa04720; hsa04723; hsa04724; hsa04725; hsa04726; hsa04727; hsa04728; hsa04730; hsa04750; hsa04911; hsa04912; hsa04916; hsa04918; hsa04919; hsa04921; hsa04925; hsa04928; hsa04931; hsa04933; hsa04960; hsa04961; hsa04970; hsa04971; hsa04972; hsa04973; hsa05031; hsa05032; hsa05140; hsa05143; hsa05146; hsa05161; hsa05163; hsa05164; hsa05170; hsa05200; hsa05205; hsa05206; hsa05214; hsa05223; hsa05225; hsa05231 2I0E 40.7%
18 PDE1A P54750 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A hsa00230; hsa04020; hsa04740; hsa04742; hsa04924; hsa05032 1LXQ 40.6%
19 CDK6 Q00534 Cyclin-dependent kinase 6 hsa04110; hsa04115; hsa04151; hsa04218; hsa04934; hsa05161; hsa05162; hsa05163; hsa05165; hsa05167; hsa05200; hsa05203; hsa05206; hsa05212; hsa05214; hsa05218; hsa05220; hsa05222; hsa05223; hsa05224; hsa05225 1BI7; 1BI8; 1BLX; 1G3N; 1JOW; 1XO2; 2EUF; 2F2C; 3NUP; 3NUX; 4AUA; 4EZ5; 4TTH 39.9%
20 PLAU P00749 Urokinase-type plasminogen activator hsa04064; hsa04610; hsa05202; hsa05205; hsa05206; hsa05215 39.4%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.