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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB04315
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB04315 Guanosine-5'-Diphosphate Thumb

36 known interactions (targets) of input drug (DB04315): Guanosine-5'-Diphosphate
No. Gene UniProt ID Protein Name Pathway PDB
1 ARL5A Q9Y689 ADP-ribosylation factor-like protein 5A NA 1Z6Y; 1ZJ6; 2H16; 2H17
2 CDC42 P60953 Cell division control protein 42 homolog hsa04010; hsa04014; hsa04015; hsa04062; hsa04144; hsa04360; hsa04370; hsa04510; hsa04520; hsa04530; hsa04660; hsa04666; hsa04670; hsa04722; hsa04810; hsa04912; hsa04932; hsa04933; hsa05100; hsa05120; hsa05130; hsa05131; hsa05132; hsa05165; hsa05200; hsa05203; hsa05205; hsa05211; hsa05212
3 GNAT1 P11488 Guanine nucleotide-binding protein G(t) subunit alpha-1 hsa04744 3RBQ
4 IRGC Q6NXR0 Interferon-inducible GTPase 5 NA NA
5 RAP2A P10114 Ras-related protein Rap-2a NA 1KAO; 2RAP; 3RAP
6 ARL3 P36405 ADP-ribosylation factor-like protein 3 NA NA
7 NME2 P22392 Nucleoside diphosphate kinase B NA 1NSK; 1NUE; 3BBB; 3BBC; 3BBF
8 NME1 P15531 Nucleoside diphosphate kinase A hsa00230; hsa00240; hsa00983; hsa01100 1JXV; 1UCN; 2HVD; 2HVE; 3L7U; 4ENO
9 RAB8B Q92930 Ras-related protein Rab-8B hsa04530 NA
10 TGM3 Q08188 Protein-glutamine gamma-glutamyltransferase E NA 1L9M; 1L9N; 1NUD; 1NUF; 1NUG
11 ARF6 P62330 ADP-ribosylation factor 6 hsa04014; hsa04072; hsa04144; hsa04666 1E0S; 2A5D; 2A5F; 2A5G; 2BAO; 2BAU; 2J5X; 2W83; 3LVQ; 3LVR; 3N5C; 3PCR; 4FME; 4KAX
12 SAR1B Q9Y6B6 GTP-binding protein SAR1b hsa04141; hsa05134 NA
13 TUFM P49411 Elongation factor Tu, mitochondrial NA NA
14 RHEB Q15382 GTP-binding protein Rheb hsa04072; hsa04140; hsa04150; hsa04151; hsa04152; hsa04211; hsa04218; hsa04714; hsa04910; hsa04919; hsa05163; hsa05165; hsa05231 1XTQ; 1XTR; 1XTS; 3SEA; 3T5G
15 RAN P62826 GTP-binding nuclear protein Ran hsa03008; hsa03013; hsa05166; hsa05169
16 EEF1A1 P68104 Elongation factor 1-alpha 1 hsa03013; hsa05134 1SYW; 3C5J
17 GMDS O60547 GDP-mannose 4,6 dehydratase hsa00051; hsa00520; hsa01100 1T2A
18 RAB7A P51149 Ras-related protein Rab-7a hsa04137; hsa04140; hsa04144; hsa04145; hsa05132; hsa05146; hsa05152 1T91; 1YHN; 3LAW
19 RAB9A P51151 Ras-related protein Rab-9A hsa05162 1WMS
20 GNAI1 P63096 Guanine nucleotide-binding protein G(i) subunit alpha-1 hsa04015; hsa04022; hsa04024; hsa04062; hsa04071; hsa04261; hsa04360; hsa04371; hsa04540; hsa04611; hsa04670; hsa04713; hsa04723; hsa04724; hsa04725; hsa04726; hsa04727; hsa04728; hsa04730; hsa04914; hsa04915; hsa04916; hsa04921; hsa04923; hsa04924; hsa04926; hsa04928; hsa04934; hsa04971; hsa05012; hsa05030; hsa05032; hsa05034; hsa05133; hsa05142; hsa05145; hsa05163; hsa05170; hsa05200 1KJY; 1Y3A; 2G83; 2GTP; 2IK8; 2OM2; 2PZ3; 2XNS; 3ONW; 3QE0; 3QI2; 3UMR; 3UMS; 4G5Q
21 GSPT1 P15170 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A hsa03015 3E1Y; 3J5Y; 3KUI; 4D61
22 RALA P11233 Ras-related protein Ral-A hsa04014; hsa04015; hsa04072; hsa05200; hsa05210; hsa05212 1UAD; 1ZC3; 1ZC4; 2A78; 2A9K; 2BOV
23 ARL1 P40616 ADP-ribosylation factor-like protein 1 NA 1UPT; 4DCN
24 HRAS P01112 GTPase HRas hsa01521; hsa01522; hsa04010; hsa04012; hsa04014; hsa04015; hsa04062; hsa04068; hsa04071; hsa04072; hsa04137; hsa04140; hsa04144; hsa04150; hsa04151; hsa04210; hsa04211; hsa04213; hsa04218; hsa04360; hsa04370; hsa04371; hsa04510; hsa04540; hsa04550; hsa04625; hsa04630; hsa04650; hsa04660; hsa04662; hsa04664; hsa04714; hsa04720; hsa04722; hsa04725; hsa04726; hsa04730; hsa04810; hsa04910; hsa04912; hsa04915; hsa04916; hsa04917; hsa04919; hsa04921; hsa04926; hsa04933; hsa05034; hsa05160; hsa05161; hsa05163; hsa05165; hsa05166; hsa05167; hsa05170; hsa05200; hsa05203; hsa05205; hsa05206; hsa05210; hsa05211; hsa05213; hsa05214; hsa05215; hsa05216; hsa05218; hsa05219; hsa05220; hsa05221; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231
121P; 1AA9; 1AGP; 1BKD; 1CLU; 1CRP; 1CRQ; 1CRR; 1CTQ; 1GNP; 1GNQ; 1GNR; 1HE8; 1IAQ; 1IOZ; 1JAH; 1JAI; 1K8R; 1LF0; 1LF5; 1LFD; 1NVU; 1NVV; 1NVW; 1NVX; 1P2S; 1P2T; 1P2U; 1P2V; 1PLJ; 1PLK; 1PLL; 1Q21; 1QRA; 1RVD; 1WQ1; 1XCM; 1XD2; 1XJ0; 1ZVQ; 1ZW6; 221P; 2C5L; 2CE2; 2CL0; 2CL6; 2CL7; 2CLC; 2CLD; 2EVW; 2GDP; 2LCF; 2LWI; 2N42; 2N46; 2Q21; 2QUZ; 2RGA; 2RGB; 2RGC; 2RGD; 2RGE; 2RGG; 2UZI; 2VH5; 2X1V; 3DDC; 3I3S; 3K8Y; 3K9L; 3K9N; 3KKM; 3KKN; 3KUD; 3L8Y; 3L8Z; 3LBH; 3LBI; 3LBN; 3LO5; 3OIU; 3OIV; 3OIW; 3RRY; 3RRZ; 3RS0; 3RS2; 3RS3; 3RS4; 3RS5; 3RS7; 3RSL; 3RSO; 3TGP; 421P; 4DLR; 4DLS; 4DLT; 4DLU; 4DLV; 4DLW; 4DLX; 4DLY; 4DLZ; 4DST; 4DSU; 4EFL; 4EFM; 4EFN; 4G0N; 4G3X; 4K81; 4L9S; 4L9W; 4NYI; 4NYJ; 4NYM; 4Q21; 4RSG; 4URU; 4URV; 4URW; 4URX; 4URY; 4URZ; 4US0; 4US1; 4US2; 4XVQ; 4XVR; 521P; 5P21; 621P; 6Q21; 721P; 821P
25 ARF1 P84077 ADP-ribosylation factor 1 hsa04072; hsa04144; hsa05110; hsa05134 1HUR; 1RE0; 1U81; 3O47; 4HMY
26 ADSSL1 Q8N142 Adenylosuccinate synthetase isozyme 1 hsa00230; hsa00250; hsa01100 2GJO
27 EIF2S3 P41091 Eukaryotic translation initiation factor 2 subunit 3 hsa03013 NA
28 TGM2 P21980 Protein-glutamine gamma-glutamyltransferase 2 hsa05016 1FAU; 1KV3; 2Q3Z; 3LY6; 3S3J; 3S3P; 3S3S; 4PYG
29 RHOA P61586 Transforming protein RhoA hsa04014; hsa04015; hsa04022; hsa04024; hsa04062; hsa04071; hsa04072; hsa04144; hsa04150; hsa04270; hsa04310; hsa04350; hsa04360; hsa04510; hsa04520; hsa04530; hsa04611; hsa04621; hsa04625; hsa04660; hsa04670; hsa04722; hsa04810; hsa04921; hsa04928; hsa04972; hsa05100; hsa05130; hsa05133; hsa05152; hsa05163; hsa05200; hsa05203; hsa05205; hsa05206; hsa05210; hsa05418
30 RAB11A P62491 Ras-related protein Rab-11A hsa04144; hsa04961; hsa04962; hsa04972 1OIV; 1OIW; 1OIX; 1YZK; 2D7C; 2GZD; 2GZH; 2HV8; 4C4P; 4D0L; 4D0M; 4LWZ; 4LX0; 4UJ3; 4UJ4; 4UJ5
31 ARL5B Q96KC2 ADP-ribosylation factor-like protein 5B NA 1YZG
32 ARF4 P18085 ADP-ribosylation factor 4 NA 1Z6X
33 EFTUD1 Q7Z2Z2 Elongation factor Tu GTP-binding domain-containing protein 1 hsa03008 5ANB; 5ANC
34 RAB5A P20339 Ras-related protein Rab-5A hsa04014; hsa04144; hsa04145; hsa04962; hsa05014; hsa05146; hsa05152 1N6H; 1N6I; 1N6K; 1N6L; 1N6N; 1N6O; 1N6P; 1N6R; 1R2Q; 1TU3; 1TU4; 3MJH; 4Q9U
35 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 hsa04010; hsa04014; hsa04015; hsa04024; hsa04062; hsa04071; hsa04145; hsa04151; hsa04310; hsa04360; hsa04370; hsa04380; hsa04510; hsa04520; hsa04530; hsa04620; hsa04650; hsa04662; hsa04664; hsa04666; hsa04670; hsa04722; hsa04810; hsa04932; hsa04933; hsa04972; hsa05014; hsa05100; hsa05120; hsa05131; hsa05132; hsa05163; hsa05167; hsa05170; hsa05200; hsa05203; hsa05205; hsa05210; hsa05211; hsa05212; hsa05231; hsa05416; hsa05418
36 EEF2 P13639 Elongation factor 2 hsa04152; hsa04921 4V6X

20 predicted interactions (targets) of input drug (DB04315): Guanosine-5'-Diphosphate
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 PRKACA P17612 cAMP-dependent protein kinase catalytic subunit alpha hsa01522; hsa04010; hsa04014; hsa04020; hsa04024; hsa04062; hsa04114; hsa04140; hsa04211; hsa04213; hsa04261; hsa04270; hsa04310; hsa04340; hsa04371; hsa04530; hsa04540; hsa04611; hsa04713; hsa04714; hsa04720; hsa04723; hsa04724; hsa04725; hsa04726; hsa04727; hsa04728; hsa04740; hsa04742; hsa04750; hsa04910; hsa04911; hsa04912; hsa04913; hsa04914; hsa04915; hsa04916; hsa04918; hsa04919; hsa04921; hsa04922; hsa04923; hsa04924; hsa04925; hsa04926; hsa04927; hsa04928; hsa04934; hsa04961; hsa04962; hsa04970; hsa04971; hsa04976; hsa05012; hsa05020; hsa05030; hsa05031; hsa05032; hsa05034; hsa05110; hsa05146; hsa05163; hsa05165; hsa05166; hsa05169; hsa05200; hsa05203; hsa05205; hsa05414 50.2%
2 ITGA4 P13612 Integrin alpha-4 hsa04151; hsa04510; hsa04512; hsa04514; hsa04640; hsa04670; hsa04672; hsa04810; hsa05140; hsa05165; hsa05410; hsa05412; hsa05414 3V4P; 3V4V; 4HKC 39.6%
3 SLC12A3 P55017 Solute carrier family 12 member 3 NA NA 39.3%
4 AHCY P23526 Adenosylhomocysteinase hsa00270; hsa01100 1A7A; 1LI4; 3NJ4; 4PFJ; 4PGF 36.4%
5 ITGB3 P05106 Integrin beta-3 hsa04015; hsa04145; hsa04151; hsa04380; hsa04510; hsa04512; hsa04611; hsa04640; hsa04810; hsa04919; hsa05163; hsa05165; hsa05205; hsa05206; hsa05410; hsa05412; hsa05414; hsa05418 31.9%
6 TF P02787 Serotransferrin hsa04066; hsa04216; hsa04978 30.9%
7 MAP2K1 Q02750 Dual specificity mitogen-activated protein kinase kinase 1 hsa01521; hsa01522; hsa04010; hsa04012; hsa04014; hsa04015; hsa04022; hsa04024; hsa04062; hsa04066; hsa04068; hsa04071; hsa04072; hsa04114; hsa04140; hsa04150; hsa04151; hsa04210; hsa04218; hsa04270; hsa04370; hsa04371; hsa04380; hsa04510; hsa04540; hsa04550; hsa04620; hsa04650; hsa04660; hsa04662; hsa04664; hsa04666; hsa04668; hsa04720; hsa04722; hsa04725; hsa04726; hsa04730; hsa04810; hsa04910; hsa04912; hsa04914; hsa04915; hsa04916; hsa04917; hsa04919; hsa04921; hsa04926; hsa04928; hsa04934; hsa05020; hsa05034; hsa05161; hsa05163; hsa05164; hsa05165; hsa05167; hsa05170; hsa05200; hsa05205; hsa05206; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05216; hsa05218; hsa05219; hsa05220; hsa05221; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231 30.7%
8 CFTR P13569 Cystic fibrosis transmembrane conductance regulator hsa02010; hsa04024; hsa04152; hsa04530; hsa04971; hsa04972; hsa04976; hsa05110 1NBD; 1XMI; 1XMJ; 2BBO; 2BBS; 2BBT; 2LOB; 2PZE; 2PZF; 2PZG; 3GD7; 3ISW 30.0%
9 GLUD1 P00367 Glutamate dehydrogenase 1, mitochondrial hsa00220; hsa00250; hsa00471; hsa00910; hsa01100; hsa01200; hsa04217; hsa04964 1L1F; 1NR1 29.7%
10 IFNAR1 P17181 Interferon alpha/beta receptor 1 hsa04060; hsa04151; hsa04217; hsa04380; hsa04620; hsa04621; hsa04630; hsa04650; hsa05160; hsa05161; hsa05162; hsa05164; hsa05165; hsa05167; hsa05168; hsa05200 3S98; 3SE3; 3SE4; 4PO6 29.7%
11 ORM1 P02763 Alpha-1-acid glycoprotein 1 NA 3KQ0 29.6%
12 DAO P14920 D-amino-acid oxidase hsa00260; hsa00330; hsa00472; hsa01100; hsa04146 2DU8; 2E48; 2E49; 2E4A; 2E82; 2GNZ; 3CUK; 3G3E; 3W4I; 3W4J; 3W4K; 3ZNN; 3ZNO; 3ZNP; 3ZNQ; 4QFC; 4QFD 29.5%
13 PLAU P00749 Urokinase-type plasminogen activator hsa04064; hsa04610; hsa05202; hsa05205; hsa05206; hsa05215 29.5%
14 TGFBR1 P36897 TGF-beta receptor type-1 hsa04010; hsa04060; hsa04068; hsa04144; hsa04218; hsa04350; hsa04371; hsa04380; hsa04390; hsa04520; hsa04659; hsa04926; hsa04933; hsa05142; hsa05161; hsa05166; hsa05200; hsa05210; hsa05212; hsa05220; hsa05225; hsa05226 28.0%
15 AURKA O14965 Aurora kinase A hsa04114; hsa04914 27.7%
16 TPI1 P60174 Triosephosphate isomerase hsa00010; hsa00051; hsa00562; hsa01100; hsa01200; hsa01230 1HTI; 1KLG; 1KLU; 1WYI; 2IAM; 2IAN; 2JK2; 2VOM; 4BR1; 4E41; 4POC; 4POD; 4UNK; 4UNL 27.7%
17 PNLIPRP2 P54317 Pancreatic lipase-related protein 2 hsa00561; hsa01100; hsa04972; hsa04975 2OXE; 2PVS 27.6%
18 CDK6 Q00534 Cyclin-dependent kinase 6 hsa04110; hsa04115; hsa04151; hsa04218; hsa04934; hsa05161; hsa05162; hsa05163; hsa05165; hsa05167; hsa05200; hsa05203; hsa05206; hsa05212; hsa05214; hsa05218; hsa05220; hsa05222; hsa05223; hsa05224; hsa05225 1BI7; 1BI8; 1BLX; 1G3N; 1JOW; 1XO2; 2EUF; 2F2C; 3NUP; 3NUX; 4AUA; 4EZ5; 4TTH 27.6%
19 PRDX6 P30041 Peroxiredoxin-6 hsa01100 1PRX 27.5%
20 GPI P06744 Glucose-6-phosphate isomerase hsa00010; hsa00030; hsa00500; hsa00520; hsa01100; hsa01200 1IAT; 1IRI; 1JIQ; 1JLH; 1NUH 27.5%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.