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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB00145
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00145 Glycine Thumb


31 known interactions (targets) of input drug (DB00145): Glycine
No. Gene UniProt ID Protein Name Pathway PDB
1 AGXT2 Q9BYV1 Alanine--glyoxylate aminotransferase 2, mitochondrial hsa00250; hsa00260; hsa00270; hsa00280; hsa01100 NA
2 GCAT O75600 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial hsa00260 NA
3 SHMT2 P34897 Serine hydroxymethyltransferase, mitochondrial hsa00260; hsa00630; hsa00670; hsa01100; hsa01200; hsa01230; hsa01523 3OU5; 4PVF
4 GLRB P48167 Glycine receptor subunit beta hsa04080 NA
5 ALAS1 P13196 5-aminolevulinate synthase, nonspecific, mitochondrial hsa00260; hsa00860; hsa01100 NA
6 GPR18 Q14330 N-arachidonyl glycine receptor NA NA
7 SLC36A1 Q7Z2H8 Proton-coupled amino acid transporter 1 hsa04974 NA
8 GLRA2 P23416 Glycine receptor subunit alpha-2 hsa04080 NA
9 GLYATL1 Q969I3 Glycine N-acyltransferase-like protein 1 NA NA
10 AGXT P21549 Serine--pyruvate aminotransferase hsa00250; hsa00260; hsa00630; hsa01100; hsa01200; hsa04146 1H0C; 1J04; 2YOB; 3R9A; 4CBR; 4CBS; 4I8A; 4KXK; 4KYO
11 GNMT Q14749 Glycine N-methyltransferase hsa00260 1R74; 2AZT
12 SLC6A5 Q9Y345 Sodium- and chloride-dependent glycine transporter 2 NA NA
13 GLYAT Q6IB77 Glycine N-acyltransferase hsa00360 NA
14 GSS P48637 Glutathione synthetase hsa00270; hsa00480; hsa01100; hsa04216 2HGS
15 GLDC P23378 Glycine dehydrogenase (decarboxylating), mitochondrial hsa00260; hsa00630; hsa01100; hsa01200 NA
16 GLYATL2 Q8WU03 Glycine N-acyltransferase-like protein 2 NA NA
17 BAAT Q14032 Bile acid-CoA:amino acid N-acyltransferase hsa00120; hsa00430; hsa01040; hsa01100; hsa04146; hsa04976 NA
18 ALAS2 P22557 5-aminolevulinate synthase, erythroid-specific, mitochondrial hsa00260; hsa00860; hsa01100 NA
19 GRIN2A Q12879 Glutamate receptor ionotropic, NMDA 2A hsa04014; hsa04015; hsa04020; hsa04024; hsa04080; hsa04713; hsa04720; hsa04724; hsa04728; hsa05010; hsa05014; hsa05030; hsa05031; hsa05033; hsa05034; hsa05322 3NFL
20 PIPOX Q9P0Z9 Peroxisomal sarcosine oxidase hsa00260; hsa00310; hsa01100; hsa04146 NA
21 SLC6A9 P48067 Sodium- and chloride-dependent glycine transporter 1 NA NA
22 SHMT1 P34896 Serine hydroxymethyltransferase, cytosolic hsa00260; hsa00630; hsa00670; hsa01100; hsa01200; hsa01230; hsa01523 1BJ4
23 GLRA1 P23415 Glycine receptor subunit alpha-1 hsa04080 1MOT; 1VRY; 2M6B; 2M6I; 4X5T
24 GCSH P23434 Glycine cleavage system H protein, mitochondrial hsa00260; hsa00630; hsa01100; hsa01200 NA
25 GRIN3B O60391 Glutamate receptor ionotropic, NMDA 3B hsa04024; hsa04080; hsa04724; hsa05030; hsa05031; hsa05033; hsa05034 NA
26 GATM P50440 Glycine amidinotransferase, mitochondrial hsa00260; hsa00330; hsa01100 1JDW; 1JDX; 2JDW; 2JDX; 3JDW; 4JDW; 5JDW; 6JDW; 7JDW; 8JDW; 9JDW
27 GARS P41250 Glycine--tRNA ligase hsa00970 2PME; 2PMF; 2Q5H; 2Q5I; 2ZT5; 2ZT6; 2ZT7; 2ZT8; 2ZXF; 4KQE; 4KR2; 4KR3; 4QEI
28 GLRA3 O75311 Glycine receptor subunit alpha-3 hsa04080 5CFB
29 SLC32A1 Q9H598 Vesicular inhibitory amino acid transporter hsa04721; hsa04723; hsa04727; hsa05032; hsa05033 NA
30 NA Q53ET4 Serine hydroxymethyltransferase NA NA
31 GRIN2C Q14957 Glutamate receptor ionotropic, NMDA 2C hsa04020; hsa04024; hsa04080; hsa04713; hsa04720; hsa04724; hsa05010; hsa05014; hsa05030; hsa05031; hsa05033; hsa05034 NA


20 predicted interactions (targets) of input drug (DB00145): Glycine
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 GRIN2B Q13224 Glutamate receptor ionotropic, NMDA 2B hsa04014; hsa04015; hsa04024; hsa04080; hsa04713; hsa04720; hsa04724; hsa04728; hsa05010; hsa05014; hsa05016; hsa05030; hsa05031; hsa05033; hsa05034; hsa05322 1S11; 1S2S; 2IPV 60.0%
2 GRIN2D O15399 Glutamate receptor ionotropic, NMDA 2D hsa04020; hsa04024; hsa04080; hsa04713; hsa04720; hsa04724; hsa05010; hsa05014; hsa05030; hsa05031; hsa05033; hsa05034 NA 54.9%
3 IGF1R P08069 Insulin-like growth factor 1 receptor hsa01521; hsa01522; hsa04010; hsa04014; hsa04015; hsa04066; hsa04068; hsa04114; hsa04140; hsa04144; hsa04150; hsa04151; hsa04152; hsa04211; hsa04213; hsa04510; hsa04520; hsa04550; hsa04730; hsa04913; hsa04914; hsa05200; hsa05202; hsa05205; hsa05214; hsa05215; hsa05218; hsa05224; hsa05225 1IGR; 1JQH; 1K3A; 1M7N; 1P4O; 2OJ9; 2ZM3; 3D94; 3F5P; 3I81; 3LVP; 3LW0; 3NW5; 3NW6; 3NW7; 3O23; 3QQU; 4D2R; 4XSS 50.2%
4 CHRNA4 P43681 Neuronal acetylcholine receptor subunit alpha-4 hsa04080; hsa04725; hsa05033 2GVT; 2LLY 43.6%
5 GRIN1 Q05586 Glutamate receptor ionotropic, NMDA 1 hsa04014; hsa04015; hsa04020; hsa04024; hsa04080; hsa04713; hsa04720; hsa04724; hsa05010; hsa05014; hsa05016; hsa05030; hsa05031; hsa05033; hsa05034 2HQW; 2NR1; 3BYA 42.5%
6 GRIA2 P42262 Glutamate receptor 2 hsa04024; hsa04080; hsa04713; hsa04720; hsa04723; hsa04724; hsa04728; hsa04730; hsa05014; hsa05030; hsa05031; hsa05033 2WJW; 2WJX; 2XHD; 3R7X; 3RN8; 3RNN; 3UA8 41.4%
7 BCAT1 P54687 Branched-chain-amino-acid aminotransferase, cytosolic hsa00270; hsa00280; hsa00290; hsa00770; hsa01100; hsa01210; hsa01230 2ABJ; 2COG; 2COI; 2COJ 40.8%
8 GRIN3A Q8TCU5 Glutamate receptor ionotropic, NMDA 3A hsa04024; hsa04080; hsa04724; hsa05030; hsa05031; hsa05033; hsa05034 NA 39.2%
9 SULT2B1 O00204 Sulfotransferase family cytosolic 2B member 1 hsa00140 1Q1Q; 1Q1Z; 1Q20; 1Q22 39.2%
10 CSAD Q9Y600 Cysteine sulfinic acid decarboxylase hsa00430; hsa01100 2JIS 38.6%
11 SLC7A11 Q9UPY5 Cystine/glutamate transporter hsa04216 NA 37.5%
12 NOS1 P29475 Nitric oxide synthase, brain hsa00220; hsa00330; hsa01100; hsa04020; hsa04145; hsa04371; hsa04713; hsa04730; hsa04926; hsa04970; hsa05010; hsa05014 4D1N; 4UCH; 4UH5; 4UH6; 4V3U; 5ADF; 5ADG; 5ADI 37.3%
13 ESR1 P03372 Estrogen receptor hsa01522; hsa04915; hsa04917; hsa04919; hsa04961; hsa05200; hsa05205; hsa05224 37.1%
14 OAT P04181 Ornithine aminotransferase, mitochondrial hsa00330; hsa01100 1GBN; 1OAT; 2BYJ; 2BYL; 2CAN; 2OAT 35.7%
15 GRIK2 Q13002 Glutamate receptor ionotropic, kainate 2 hsa04080; hsa04724 3QXM 35.6%
16 NQO1 P15559 NAD(P)H dehydrogenase [quinone] 1 hsa00130; hsa05200; hsa05225; hsa05418 1D4A; 1DXO; 1GG5; 1H66; 1H69; 1KBO; 1KBQ; 1QBG; 2F1O; 3JSX; 4CET; 4CF6 34.7%
17 GABRB3 P28472 Gamma-aminobutyric acid receptor subunit beta-3 hsa04080; hsa04723; hsa04726; hsa04727; hsa05032; hsa05033 4COF 34.5%
18 IGHG1 P01857 Ig gamma-1 chain C region NA
1AJ7; 1AQK; 1BEY; 1D5B; 1D5I; 1D6V; 1DFB; 1DN2; 1E4K; 1FC1; 1FC2; 1FCC; 1GAF; 1H3T; 1H3U; 1H3V; 1H3W; 1H3X; 1H3Y; 1HKL; 1HZH; 1I7Z; 1L6X; 1N7M; 1OP3; 1OQO; 1OQX; 1T83; 1T89; 1VGE; 2DTS; 2GJ7; 2I5Y; 2IWG; 2J6E; 2JB5; 2JB6; 2O5X; 2O5Y; 2O5Z; 2OSL; 2QAD; 2QL1; 2QQK; 2QQL; 2QQN; 2QR0; 2R56; 2RCJ; 2RCS; 2VXQ; 2WAH; 3AGV; 3AVE; 3AY4; 3B2U; 3B2V; 3BDY; 3BE1; 3BKY; 3BN9; 3BQU; 3C08; 3C09; 3C2S; 3CFJ; 3CFK; 3CSY; 3D0L; 3D0V; 3D6G; 3D85; 3DJ9; 3DNK; 3DO3; 3DRO; 3DRQ; 3DVG; 3DVN; 3EYF; 3EYO; 3EYQ; 3FJT; 3O11; 3RY6; 3S7G; 3SGJ; 3SGK; 3TV3; 3TWC; 3TYG; 3U0W; 3U7W; 3U7Y; 3V7M; 3V8C; 3V95; 3WJJ; 3WJL; 3WKN; 3WN5; 4ACP; 4B7I; 4BM7; 4BSV; 4BSW; 4BYH; 4CDH; 4D9Q; 4D9R; 4DAG; 4DZ8; 4EOW; 4J12; 4KU1; 4LLD; 4LLM; 4LLQ; 4N0U; 4NQS; 4NQT; 4NQU; 4NWT; 4NWU; 4O4Y; 4O51; 4Q6Y; 4Q74; 4Q7D; 4W4N; 4W4O; 4WI2; 4WI3; 4WI4; 4WI5; 4WI6; 4WI7; 4WI8; 4WI9; 4X4M; 4X98; 4X99; 4ZNE; 5BW7
 32.1%
19 BCAT2 O15382 Branched-chain-amino-acid aminotransferase, mitochondrial hsa00270; hsa00280; hsa00290; hsa00770; hsa01100; hsa01210; hsa01230 1EKF; 1EKP; 1EKV; 1KT8; 1KTA; 2A1H; 2HDK; 2HG8; 2HGW; 2HGX; 2HHF; 5BWR; 5BWT; 5BWU; 5BWV; 5BWW; 5BWX; 5CR5 32.1%
20 ARG1 P05089 Arginase-1 hsa00220; hsa00330; hsa01100; hsa01230; hsa05146 30.6%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.