QuartataWeb 1.0

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB00922

No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter Image

1 Approved;
Investigational SmallMoleculeDrug DB00922 Levosimendan
C[C@@H]1CC(=O)NN=C1C1=CC=C(NN=C(C#N)C#N)C=C1

4 known interactions (targets) of input drug (DB00922): Levosimendan

No.	Gene	UniProt ID	Protein Name	Pathway	PDB
1	KCNJ11	Q14654	ATP-sensitive inward rectifier potassium channel 11	hsa04911; hsa04930	NA
2	PDE3A	Q14432	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	hsa00230; hsa04022; hsa04024; hsa04924; hsa05032	1LRC
3	TNNC1	P63316	Troponin C, slow skeletal and cardiac muscles	hsa04020; hsa04260; hsa04261; hsa05410; hsa05414	1AP4; 1IH0; 1J1D; 1J1E; 1LXF; 1MXL; 1OZS; 1SPY; 1WRK; 1WRL; 2JT0; 2JT3; 2JT8; 2JTZ; 2JXL; 2KDH; 2KFX; 2KGB; 2KRD; 2L1R; 2L98; 2MKP; 2MLE; 2MLF; 2MZP; 2N79; 3RV5; 3SD6; 3SWB; 4GJE; 4GJF; 4GJG
4	KCNJ8	Q15842	ATP-sensitive inward rectifier potassium channel 8	hsa04022	NA

20 predicted interactions (targets) of input drug (DB00922): Levosimendan

No.	Gene	UniProt ID	Protein Name	Pathway	PDB	Confidence score
1	KCNJ1	P48048	ATP-sensitive inward rectifier potassium channel 1	hsa04960; hsa04971	NA	36.2%
2	KCNJ12	Q14500	ATP-sensitive inward rectifier potassium channel 12	hsa04725; hsa04921	NA	34.0%
3	SLC6A2	P23975	Sodium-dependent noradrenaline transporter	NA	NA	29.2%
4	ABCC8	Q09428	ATP-binding cassette sub-family C member 8	hsa02010; hsa04911; hsa04930	NA	28.6%
5	CACNA2D2	Q9NY47	Voltage-dependent calcium channel subunit alpha-2/delta-2	hsa04010; hsa04260; hsa04261; hsa04921; hsa05410; hsa05412; hsa05414	NA	28.3%
6	SLC6A3	Q01959	Sodium-dependent dopamine transporter	hsa04728; hsa05012; hsa05030; hsa05031; hsa05034	NA	28.2%
7	KCNJ15	Q99712	ATP-sensitive inward rectifier potassium channel 15	hsa04971	NA	27.8%
8	CACNA1A	O00555	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	hsa04010; hsa04020; hsa04721; hsa04723; hsa04724; hsa04725; hsa04726; hsa04727; hsa04728; hsa04730; hsa04742; hsa04930; hsa05032; hsa05033	3BXK	26.9%
9	DRD2	P14416	D(2) dopamine receptor	hsa04015; hsa04024; hsa04080; hsa04540; hsa04728; hsa05012; hsa05030; hsa05034	1I15; 5AER	26.0%
10	CACNG1	Q06432	Voltage-dependent calcium channel gamma-1 subunit	hsa04010; hsa04260; hsa04261; hsa04921; hsa05410; hsa05412; hsa05414	NA	26.0%
11	PDE1B	Q01064	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	hsa00230; hsa04020; hsa04740; hsa04742; hsa04924; hsa05032	1LXR; 1TAZ; 4NPV; 4NPW	25.7%
12	PDE1A	P54750	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	hsa00230; hsa04020; hsa04740; hsa04742; hsa04924; hsa05032	1LXQ	25.6%
13	CACNB1	Q02641	Voltage-dependent L-type calcium channel subunit beta-1	hsa04010; hsa04260; hsa04261; hsa04921; hsa05410; hsa05412; hsa05414	NA	25.6%
14	ADRA2C	P18825	Alpha-2C adrenergic receptor	hsa04022; hsa04080	NA	25.5%
15	SLC6A4	P31645	Sodium-dependent serotonin transporter	hsa04726	NA	25.3%
16	ADRA2B	P18089	Alpha-2B adrenergic receptor	hsa04022; hsa04080	2CVA	25.2%
17	NOS3	P29474	Nitric oxide synthase, endothelial	hsa00220; hsa00330; hsa01100; hsa04020; hsa04022; hsa04066; hsa04071; hsa04151; hsa04370; hsa04371; hsa04611; hsa04915; hsa04921; hsa04926; hsa04931; hsa04933; hsa05418	1M9J; 1M9K; 1M9M; 1M9Q; 1M9R; 1NIW; 2LL7; 2MG5; 3EAH; 3NOS; 4D1O; 4D1P	24.6%
18	ADRA2A	P08913	Alpha-2A adrenergic receptor	hsa04022; hsa04080	1HLL; 1HO9; 1HOD; 1HOF	24.4%
19	CACNA2D1	P54289	Voltage-dependent calcium channel subunit alpha-2/delta-1	hsa04010; hsa04260; hsa04261; hsa04921; hsa05410; hsa05412; hsa05414	NA	24.4%
20	ADRB3	P13945	Beta-3 adrenergic receptor	hsa04020; hsa04022; hsa04080; hsa04714; hsa04923; hsa04924; hsa04970	2CDW	24.3%