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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB11638
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB11638 Artenimol Thumb


78 known interactions (targets) of input drug (DB11638): Artenimol
No. Gene UniProt ID Protein Name Pathway PDB
1 SFPQ P23246 Splicing factor, proline- and glutamine-rich NA 4WII; 4WIJ; 4WIK
2 RPL4 P36578 60S ribosomal protein L4 hsa03010 4UG0; 4V6X; 5A8L; 5AJ0; 5T2C
3 TPM1 P09493 Tropomyosin alpha-1 chain hsa04260; hsa04261; hsa05206; hsa05410; hsa05414 NA
4 DSP P15924 Desmoplakin hsa05412 1LM5; 1LM7; 3R6N; 5DZZ
5 TAGLN2 P37802 Transgelin-2 NA 1WYM
6 RPL35 P42766 60S ribosomal protein L35 hsa03010 4UG0; 4V6X; 5AJ0; 5T2C
7 HNRNPD Q14103 Heterogeneous nuclear ribonucleoprotein D0 NA 1HD0; 1HD1; 1IQT; 1WTB; 1X0F; 2Z5N; 5IM0
8 ATP5O P48047 ATP synthase subunit O, mitochondrial hsa00190; hsa01100; hsa04714; hsa05010; hsa05012; hsa05016 NA
9 LGALS1 P09382 Galectin-1 NA 1GZW; 1W6M; 1W6N; 1W6O; 1W6P; 1W6Q; 2KM2; 2ZKN; 3OY8; 3OYW; 3T2T; 3W58; 3W59; 4Q1P; 4Q1R; 4Q26; 4Q27; 4Q2F; 4XBL
10 SHMT2 P34897 Serine hydroxymethyltransferase, mitochondrial hsa00260; hsa00630; hsa00670; hsa01100; hsa01200; hsa01230; hsa01523 3OU5; 4PVF
11 RPS19 P39019 40S ribosomal protein S19 hsa03010 4UG0; 4V6X; 5A2Q; 5AJ0; 5FLX; 5T2C
12 TUBA1A Q71U36 Tubulin alpha-1A chain hsa04145; hsa04210; hsa04530; hsa04540; hsa05130 5JCO
13 HNRNPA2B1 P22626 Heterogeneous nuclear ribonucleoproteins A2/B1 NA 1X4B; 5EN1; 5HO4
14 TUBB6 Q9BUF5 Tubulin beta-6 chain hsa04145; hsa04540; hsa05130 NA
15 RPS9 P46781 40S ribosomal protein S9 hsa03010 4UG0; 4V6X; 5A2Q; 5AJ0; 5FLX; 5T2C
16 RPS5 P46782 40S ribosomal protein S5 hsa03010 4UG0; 4V6X; 5A2Q; 5AJ0; 5FLX; 5T2C
17 ATP5A1 P25705 ATP synthase subunit alpha, mitochondrial hsa00190; hsa01100; hsa04714; hsa05010; hsa05012; hsa05016 NA
18 ALDOA P04075 Fructose-bisphosphate aldolase A hsa00010; hsa00030; hsa00051; hsa01100; hsa01200; hsa01230; hsa04066 1ALD; 2ALD; 4ALD
19 MDH1 P40925 Malate dehydrogenase, cytoplasmic hsa00020; hsa00270; hsa00620; hsa00630; hsa01100; hsa01200; hsa04964 NA
20 PFN1 P07737 Profilin-1 hsa04015; hsa04810; hsa05131; hsa05132 1AWI; 1CF0; 1CJF; 1FIK; 1FIL; 1PFL; 2PAV; 2PBD; 3CHW; 4X1L; 4X1M; 4X25
21 PKM P14618 Pyruvate kinase PKM hsa00010; hsa00230; hsa00620; hsa01100; hsa01200; hsa01230; hsa04922; hsa04930; hsa05165; hsa05203; hsa05230
22 TUBB P07437 Tubulin beta chain hsa04145; hsa04540; hsa05130 3QNZ; 3QO0
23 PGAM1 P18669 Phosphoglycerate mutase 1 hsa00010; hsa00260; hsa01100; hsa01200; hsa01230; hsa04922; hsa05230 1LJD; 1YFK; 1YJX; 4GPI; 4GPZ
24 RPL10 P27635 60S ribosomal protein L10 hsa03010 2PA2; 5AJ0
25 SRP14 P37108 Signal recognition particle 14 kDa protein hsa03060 1E8O; 1E8S; 1RY1; 4UYJ; 4UYK; 5AOX
26 TPI1 P60174 Triosephosphate isomerase hsa00010; hsa00051; hsa00562; hsa01100; hsa01200; hsa01230 1HTI; 1KLG; 1KLU; 1WYI; 2IAM; 2IAN; 2JK2; 2VOM; 4BR1; 4E41; 4POC; 4POD; 4UNK; 4UNL
27 HSPB1 P04792 Heat shock protein beta-1 hsa04010; hsa04370; hsa05146; hsa05169 2N3J; 3Q9P; 3Q9Q; 4MJH
28 ACTG1 P63261 Actin, cytoplasmic 2 hsa04015; hsa04145; hsa04210; hsa04390; hsa04510; hsa04520; hsa04530; hsa04611; hsa04670; hsa04714; hsa04810; hsa04919; hsa04921; hsa05100; hsa05110; hsa05130; hsa05131; hsa05132; hsa05164; hsa05205; hsa05225; hsa05410; hsa05412; hsa05414; hsa05416; hsa05418 NA
29 KHSRP Q92945 Far upstream element-binding protein 2 NA 2HH2; 2HH3; 2JVZ; 2OPU; 2OPV; 4B8T
30 P4HB P07237 Protein disulfide-isomerase hsa04141 1BJX; 1MEK; 1X5C; 2BJX; 2K18; 3BJ5; 3UEM; 4EKZ; 4EL1; 4JU5
31 GAPDH P04406 Glyceraldehyde-3-phosphate dehydrogenase hsa00010; hsa01100; hsa01200; hsa01230; hsa04066; hsa05010 1U8F; 1ZNQ; 2FEH; 3GPD; 4WNC; 4WNI
32 GPI P06744 Glucose-6-phosphate isomerase hsa00010; hsa00030; hsa00500; hsa00520; hsa01100; hsa01200 1IAT; 1IRI; 1JIQ; 1JLH; 1NUH
33 CAST P20810 Calpastatin NA NA
34 LDHB P07195 L-lactate dehydrogenase B chain hsa00010; hsa00270; hsa00620; hsa00640; hsa01100; hsa04922 1I0Z; 1T2F
35 SRSF4 Q08170 Serine/arginine-rich splicing factor 4 hsa03040; hsa05168 NA
36 ALDH7A1 P49419 Alpha-aminoadipic semialdehyde dehydrogenase hsa00010; hsa00053; hsa00071; hsa00260; hsa00280; hsa00310; hsa00330; hsa00340; hsa00380; hsa00410; hsa00561; hsa00620; hsa01100 2J6L; 4X0T; 4X0U; 4ZUK; 4ZUL; 4ZVW; 4ZVX; 4ZVY
37 TUBB4A P04350 Tubulin beta-4A chain hsa04145; hsa04540; hsa05130 NA
38 CFL1 P23528 Cofilin-1 hsa04360; hsa04666; hsa04810; hsa05133; hsa05170 1Q8G; 1Q8X; 3J0S; 4BEX
39 MAP4 P27816 Microtubule-associated protein 4 NA NA
40 RPS28 P62857 40S ribosomal protein S28 hsa03010 4UG0; 4V6X; 5A2Q; 5AJ0; 5FLX; 5T2C
41 HSPA8 P11142 Heat shock cognate 71 kDa protein hsa03040; hsa04010; hsa04141; hsa04144; hsa04213; hsa04612; hsa04915; hsa05134; hsa05145; hsa05162; hsa05164; hsa05169 3AGY; 3AGZ; 3ESK; 3FZF; 3FZH; 3FZK; 3FZL; 3FZM; 3LDQ; 3M3Z; 4H5N; 4H5R; 4H5T; 4H5V; 4H5W; 4HWI; 4KBQ
42 LDHA P00338 L-lactate dehydrogenase A chain hsa00010; hsa00270; hsa00620; hsa00640; hsa01100; hsa04066; hsa04922; hsa05230 1I10; 4AJP; 4JNK; 4L4R; 4L4S; 4M49; 4OJN; 4OKN; 4QO7; 4QO8; 4QSM; 4QT0; 4R68; 4R69; 4RLS
43 EEF1A1 P68104 Elongation factor 1-alpha 1 hsa03013; hsa05134 1SYW; 3C5J
44 G6PD P11413 Glucose-6-phosphate 1-dehydrogenase hsa00030; hsa00480; hsa01100; hsa01200; hsa05230 1QKI; 2BH9; 2BHL
45 PRDX1 Q06830 Peroxiredoxin-1 hsa04146 2RII; 3HY2
46 IQGAP1 P46940 Ras GTPase-activating-like protein IQGAP1 hsa04520; hsa04810; hsa05205 1X0H; 2RR8; 3FAY; 3I6X; 5L0O
47 RPS8 P62241 40S ribosomal protein S8 hsa03010 4UG0; 4V6X; 5A2Q; 5AJ0; 5FLX; 5T2C
48 DPYSL2 Q16555 Dihydropyrimidinase-related protein 2 hsa04360 2GSE; 2VM8
49 FTO Q9C0B1 Alpha-ketoglutarate-dependent dioxygenase FTO NA 3LFM; 4CXW; 4CXX; 4CXY; 4IDZ; 4IE0; 4IE4; 4IE5; 4IE6; 4IE7; 4QHO; 4QKN; 4ZS2; 4ZS3
50 GAPDHS O14556 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific hsa00010; hsa01100 3H9E; 3PFW
51 PGK1 P00558 Phosphoglycerate kinase 1 hsa00010; hsa01100; hsa01200; hsa01230; hsa04066 2WZB; 2WZC; 2WZD; 2X13; 2X14; 2X15; 2XE6; 2XE7; 2XE8; 2Y3I; 2YBE; 2ZGV; 3C39; 3C3A; 3C3B; 3C3C; 3ZOZ; 4AXX; 4O33
52 RPL18 Q07020 60S ribosomal protein L18 hsa03010 4UG0; 4V6X; 5AJ0; 5T2C
53 HNRNPK P61978 Heterogeneous nuclear ribonucleoprotein K hsa03040; hsa05168; hsa05203; hsa05206 1J5K; 1KHM; 1ZZI; 1ZZJ; 1ZZK
54 RPL23A P62750 60S ribosomal protein L23a hsa03010 4UG0; 4V6X; 5AJ0
55 FLNA P21333 Filamin-A hsa04010; hsa04510; hsa05132; hsa05205 2AAV; 2BP3; 2BRQ; 2J3S; 2JF1; 2K3T; 2K7P; 2K7Q; 2MTP; 2W0P; 2WFN; 3CNK; 3HOC; 3HOP; 3HOR; 3ISW; 3RGH; 4M9P; 4P3W
56 SNRPD2 P62316 Small nuclear ribonucleoprotein Sm D2 hsa03040 1B34; 3CW1; 3JCR; 3PGW; 3S6N; 4F7U; 4PJO; 4V98; 4WZJ; 5MQF
57 DDX5 P17844 Probable ATP-dependent RNA helicase DDX5 hsa03040; hsa05202; hsa05205 3FE2; 4A4D
58 ANXA2 P07355 Annexin A2 NA 1W7B; 1XJL; 2HYU; 2HYV; 2HYW; 4DRW; 4FTG; 4HRH
59 CSRP1 P21291 Cysteine and glycine-rich protein 1 NA NA
60 DDX39B Q13838 Spliceosome RNA helicase DDX39B hsa03013; hsa03015; hsa03040; hsa05164 1T5I; 1T6N; 1XTI; 1XTJ; 1XTK
61 ALB P02768 Serum albumin hsa04918
62 RPS18 P62269 40S ribosomal protein S18 hsa03010 4UG0; 4V6X; 5A2Q; 5AJ0; 5FLX; 5T2C
63 CCT3 P49368 T-complex protein 1 subunit gamma NA NA
64 PPIA P62937 Peptidyl-prolyl cis-trans isomerase A hsa04217
65 ZYX Q15942 Zyxin hsa04510 NA
66 CYCS P99999 Cytochrome c hsa01524; hsa04115; hsa04210; hsa04215; hsa04932; hsa05010; hsa05012; hsa05014; hsa05016; hsa05134; hsa05145; hsa05152; hsa05161; hsa05163; hsa05164; hsa05167; hsa05168; hsa05170; hsa05200; hsa05210; hsa05222; hsa05416 1J3S; 3NWV; 3ZCF; 3ZOO
67 NPEPPS P55786 Puromycin-sensitive aminopeptidase NA NA
68 HP1BP3 Q5SSJ5 Heterochromatin protein 1-binding protein 3 NA 2RQP
69 ENO1 P06733 Alpha-enolase hsa00010; hsa01100; hsa01200; hsa01230; hsa03018; hsa04066 2PSN; 3B97
70 RPS6 P62753 40S ribosomal protein S6 hsa01521; hsa03010; hsa04066; hsa04150; hsa04151; hsa04371; hsa04714; hsa04910; hsa05205 4UG0; 4V6X; 5A2Q; 5AJ0; 5FLX; 5T2C
71 RPS13 P62277 40S ribosomal protein S13 hsa03010 4UG0; 4V6X; 5A2Q; 5AJ0; 5FLX; 5T2C
72 RPS17 P08708 40S ribosomal protein S17 hsa03010 4UG0; 4V6X; 5A2Q; 5AJ0; 5FLX; 5T2C
73 CLIC1 O00299 Chloride intracellular channel protein 1 NA 1K0M; 1K0N; 1K0O; 1RK4; 3O3T; 3P8W; 3P90; 3QR6; 3SWL; 3TGZ; 3UVH; 4IQA; 4JZQ; 4K0G; 4K0N
74 VIM P08670 Vimentin hsa05169; hsa05206 1GK4; 1GK6; 1GK7; 3G1E; 3KLT; 3S4R; 3SSU; 3SWK; 3TRT; 3UF1; 4MCY; 4MCZ; 4MD0; 4MD5; 4MDI; 4MDJ
75 RPL14 P50914 60S ribosomal protein L14 hsa03010 4UG0; 4V6X; 5AJ0; 5T2C
76 SF1 Q15637 Splicing factor 1 NA 1K1G; 1O0P; 1OPI; 2M09; 2M0G; 4FXW; 4FXX
77 ATP5L O75964 ATP synthase subunit g, mitochondrial hsa00190; hsa01100; hsa04714 NA
78 MYH9 P35579 Myosin-9 hsa04530; hsa04810; hsa05132 2LNK; 3ZWH; 4CFQ; 4CFR; 4ETO


20 predicted interactions (targets) of input drug (DB11638): Artenimol
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 TUBA3C Q13748 Tubulin alpha-3C/D chain NA NA 58.0%
2 TUBB3 Q13509 Tubulin beta-3 chain hsa04145; hsa04540; hsa05130 NA 54.5%
3 BST1 Q10588 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 hsa00760; hsa01100; hsa04970; hsa04972 1ISF; 1ISG; 1ISH; 1ISI; 1ISJ; 1ISM 52.8%
4 IDH3A P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial hsa00020; hsa01100; hsa01200; hsa01210; hsa01230 NA 49.2%
5 UGDH O60701 UDP-glucose 6-dehydrogenase hsa00040; hsa00053; hsa00520; hsa01100 2Q3E; 2QG4; 3ITK; 3KHU; 3PRJ; 3PTZ; 3TDK; 3TF5; 4EDF; 4QEJ; 4RJT 48.5%
6 C1S P09871 Complement C1s subcomponent hsa04610; hsa05133; hsa05150; hsa05322 1ELV; 1NZI; 4J1Y; 4LMF; 4LOR; 4LOS; 4LOT 47.4%
7 RANBP1 P43487 Ran-specific GTPase-activating protein hsa05166; hsa05203 1K5D; 1K5G 46.0%
8 GSR P00390 Glutathione reductase, mitochondrial hsa00480; hsa04918 45.0%
9 AR P10275 Androgen receptor hsa04114; hsa05200; hsa05215 44.4%
10 CALM1 P0DP23 Calmodulin NA 43.6%
11 BDNF P23560 Brain-derived neurotrophic factor hsa04010; hsa04014; hsa04024; hsa04151; hsa04722; hsa05016; hsa05030; hsa05034 1B8M; 1BND 42.5%
12 PLAUR Q03405 Urokinase plasminogen activator surface receptor hsa04610; hsa05205 1YWH; 2FD6; 2I9B; 3BT1; 3BT2; 3U73; 3U74; 4K24; 4QTI 40.7%
13 EDNRA P25101 Endothelin-1 receptor hsa04020; hsa04022; hsa04024; hsa04080; hsa04270; hsa04924; hsa05200 NA 40.3%
14 PRDX2 P32119 Peroxiredoxin-2 NA 1QMV 39.9%
15 DLAT P10515 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial hsa00010; hsa00020; hsa00620; hsa01100; hsa01200 1FYC; 1Y8N; 1Y8O; 1Y8P; 2DNE; 2PNR; 2Q8I; 3B8K; 3CRK; 3CRL 39.7%
16 KRT2 P35908 Keratin, type II cytoskeletal 2 epidermal NA NA 39.6%
17 ADRB2 P07550 Beta-2 adrenergic receptor hsa04020; hsa04022; hsa04024; hsa04080; hsa04261; hsa04923; hsa04924; hsa04970 1GQ4; 2R4R; 2R4S; 2RH1; 3D4S; 3KJ6; 3NY8; 3NY9; 3NYA; 3P0G; 3PDS; 3SN6; 4GBR; 4LDE; 4LDL; 4LDO; 4QKX 38.9%
18 TTR P02766 Transthyretin hsa04918
1BM7; 1BMZ; 1BZ8; 1BZD; 1BZE; 1DVQ; 1DVS; 1DVT; 1DVU; 1DVX; 1DVY; 1DVZ; 1E3F; 1E4H; 1E5A; 1ETA; 1ETB; 1F41; 1F64; 1F86; 1FH2; 1FHN; 1G1O; 1GKO; 1ICT; 1III; 1IIK; 1IJN; 1QAB; 1QWH; 1RLB; 1SOK; 1SOQ; 1THA; 1THC; 1TLM; 1TSH; 1TT6; 1TTA; 1TTB; 1TTC; 1TTR; 1TYR; 1TZ8; 1U21; 1X7S; 1X7T; 1Y1D; 1Z7J; 1ZCR; 1ZD6; 2B14; 2B15; 2B16; 2B77; 2B9A; 2F7I; 2F8I; 2FBR; 2FLM; 2G3X; 2G3Z; 2G4E; 2G4G; 2G5U; 2G9K; 2GAB; 2H4E; 2M5N; 2NOY; 2PAB; 2QEL; 2QGB; 2QGC; 2QGD; 2QGE; 2ROX; 2ROY; 2TRH; 2TRY; 2WQA; 3A4D; 3A4E; 3A4F; 3B56; 3BSZ; 3BT0; 3CBR; 3CFM; 3CFN; 3CFQ; 3CFT; 3CN0; 3CN1; 3CN2; 3CN3; 3CN4; 3CXF; 3D2T; 3D7P; 3DGD; 3DID; 3DJR; 3DJS; 3DJT; 3DJZ; 3DK0; 3DK2; 3DO4; 3ESN; 3ESO; 3ESP; 3FC8; 3FCB; 3GLZ; 3GPS; 3GRB; 3GRG; 3GS0; 3GS4; 3GS7; 3HJ0; 3I9A; 3I9I; 3I9P; 3IMR; 3IMS; 3IMT; 3IMU; 3IMV; 3IMW; 3IPB; 3IPE; 3KGS; 3KGT; 3KGU; 3M1O; 3NEE; 3NEO; 3NES; 3NEX; 3NG5; 3OZK; 3OZL; 3P3R; 3P3S; 3P3T; 3P3U; 3SSG; 3TCT; 3TFB; 3U2I; 3U2J; 3W3B; 4ABQ; 4ABU; 4ABV; 4ABW; 4AC2; 4AC4; 4ACT; 4ANK; 4DER; 4DES; 4DET; 4DEU; 4DEW; 4FI6; 4FI7; 4FI8; 4HIQ; 4HIS; 4HJS; 4HJT; 4HJU; 4I85; 4I87; 4I89; 4IIZ; 4IK6; 4IK7; 4IKI; 4IKJ; 4IKK; 4IKL; 4KY2; 4L1S; 4L1T; 4MAS; 4MRB; 4MRC; 4N85; 4N86; 4N87; 4PM1; 4PME; 4PMF; 4PVL; 4PVM; 4PVN; 4PWE; 4PWF; 4PWG; 4PWH; 4PWI; 4PWJ; 4PWK; 4QRF; 4QXV; 4QYA; 4TKW; 4TL4; 4TL5; 4TLK; 4TLS; 4TLT; 4TM9; 4TNE; 4TQ8; 4TQH; 4TQI; 4TQP; 4WNJ; 4WNS; 4WO0; 4Y9B; 4Y9C; 4Y9E; 4Y9F; 4Y9G; 4YDM; 4YDN; 5AKS; 5AKT; 5AKV; 5AL0; 5AL8; 5BOJ; 5CR1; 5TTR
 38.8%
19 CTRB1 P17538 Chymotrypsinogen B hsa04972; hsa04974 NA 38.5%
20 SNCA P37840 Alpha-synuclein hsa05010; hsa05012 1XQ8; 2JN5; 2KKW; 2M55; 2X6M; 3Q25; 3Q26; 3Q27; 3Q28; 3Q29; 4BXL; 4R0U; 4R0W; 4RIK; 4RIL; 4ZNN; 5CRW 38.5%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.