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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB14050
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB14050 Cannabidivarin Thumb


4 known interactions (targets) of input drug (DB14050): Cannabidivarin
No. Gene UniProt ID Protein Name Pathway PDB
1 TRPV1 Q8NER1 Transient receptor potential cation channel subfamily V member 1 hsa04080; hsa04750 NA
2 TRPA1 O75762 Transient receptor potential cation channel subfamily A member 1 hsa04750 3J9P
3 DAGLA F5GY58 Sn1-specific diacylglycerol lipase alpha NA NA
4 TRPV2 Q9Y5S1 Transient receptor potential cation channel subfamily V member 2 hsa04621; hsa04750 2F37


20 predicted interactions (targets) of input drug (DB14050): Cannabidivarin
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 CNR1 P21554 Cannabinoid receptor 1 hsa04015; hsa04080; hsa04714; hsa04723 1LVQ; 1LVR; 2B0Y; 2KOE 47.5%
2 TRPM8 Q7Z2W7 Transient receptor potential cation channel subfamily M member 8 hsa04750 NA 47.4%
3 CNR2 P34972 Cannabinoid receptor 2 hsa04080 2KI9 44.2%
4 TRPV3 Q8NET8 Transient receptor potential cation channel subfamily V member 3 hsa04750 NA 43.9%
5 GPR55 Q9Y2T6 G-protein coupled receptor 55 NA NA 35.7%
6 VDAC1 P21796 Voltage-dependent anion-selective channel protein 1 hsa04020; hsa04022; hsa04217; hsa04218; hsa04621; hsa04979; hsa05012; hsa05016; hsa05164; hsa05166 2JK4; 2K4T 32.7%
7 GPR12 P47775 G-protein coupled receptor 12 NA NA 32.2%
8 TRPV4 Q9HBA0 Transient receptor potential cation channel subfamily V member 4 hsa04218; hsa04750; hsa05418 4DX1; 4DX2 31.3%
9 CACNA1H O95180 Voltage-dependent T-type calcium channel subunit alpha-1H hsa04010; hsa04020; hsa04713; hsa04925; hsa04927; hsa04934 NA 30.6%
10 OPRD1 P41143 Delta-type opioid receptor hsa04022; hsa04071; hsa04080 1OZC; 2IQM; 4N6H; 4RWA; 4RWD 29.8%
11 GPR18 Q14330 N-arachidonyl glycine receptor NA NA 29.5%
12 HTR2A P28223 5-hydroxytryptamine receptor 2A hsa04020; hsa04080; hsa04540; hsa04726; hsa04750 NA 29.2%
13 GLRB P48167 Glycine receptor subunit beta hsa04080 NA 27.7%
14 SLC6A4 P31645 Sodium-dependent serotonin transporter hsa04726 NA 27.6%
15 PYGM P11217 Glycogen phosphorylase, muscle form hsa00500; hsa01100; hsa04217; hsa04910; hsa04922; hsa04931 1Z8D 26.8%
16 OPRK1 P41145 Kappa-type opioid receptor hsa04080 2A0D; 2IQN; 4DJH 25.3%
17 OPRM1 P35372 Mu-type opioid receptor hsa04080; hsa04915; hsa05032 NA 25.3%
18 HTR1A P08908 5-hydroxytryptamine receptor 1A hsa04024; hsa04080; hsa04726; hsa04742 NA 25.2%
19 CHRNA7 P36544 Neuronal acetylcholine receptor subunit alpha-7 NA 2MAW; 5AFH; 5AFJ; 5AFK; 5AFL; 5AFM; 5AFN 24.7%
20 ADORA1 P30542 Adenosine receptor A1 hsa04022; hsa04024; hsa04071; hsa04080; hsa04923; hsa04924; hsa05032 NA 24.6%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.