QuartataWeb 1.0

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB00193

No. Group Type Drug ID Drug Name SMILES
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1 Approved;
Investigational SmallMoleculeDrug DB00193 Tramadol
COC1=CC=CC(=C1)[C@@]1(O)CCCC[C@@H]1CN(C)C

10 known interactions (targets) of input drug (DB00193): Tramadol

No.	Gene	UniProt ID	Protein Name	Pathway	PDB
1	GRIN3A	Q8TCU5	Glutamate receptor ionotropic, NMDA 3A	hsa04024; hsa04080; hsa04724; hsa05030; hsa05031; hsa05033; hsa05034	NA
2	CHRNA7	Q693P7	Alpha-7 nicotinic cholinergic receptor subunit	NA	NA
3	CHRM1	P11229	Muscarinic acetylcholine receptor M1	hsa04020; hsa04024; hsa04080; hsa04151; hsa04725; hsa04810	NA
4	OPRK1	P41145	Kappa-type opioid receptor	hsa04080	2A0D; 2IQN; 4DJH
5	SLC6A4	P31645	Sodium-dependent serotonin transporter	hsa04726	NA
6	HTR2C	P28335	5-hydroxytryptamine receptor 2C	hsa04020; hsa04080; hsa04540; hsa04726; hsa04750	NA
7	OPRM1	P35372	Mu-type opioid receptor	hsa04080; hsa04915; hsa05032	NA
8	SLC6A2	P23975	Sodium-dependent noradrenaline transporter	NA	NA
9	OPRD1	P41143	Delta-type opioid receptor	hsa04022; hsa04071; hsa04080	1OZC; 2IQM; 4N6H; 4RWA; 4RWD
10	CHRM3	P20309	Muscarinic acetylcholine receptor M3	hsa04020; hsa04080; hsa04725; hsa04742; hsa04810; hsa04911; hsa04970; hsa04971; hsa04972	2CSA

20 predicted interactions (targets) of input drug (DB00193): Tramadol

No.	Gene	UniProt ID	Protein Name	Pathway	PDB	Confidence score
1	CHRM2	P08172	Muscarinic acetylcholine receptor M2	hsa04020; hsa04024; hsa04080; hsa04151; hsa04725; hsa04810	1LUB; 3UON; 4MQS; 4MQT	93.9%
2	HRH1	P35367	Histamine H1 receptor	hsa04020; hsa04080; hsa04750	3RZE	81.5%
3	CHRM4	P08173	Muscarinic acetylcholine receptor M4	hsa04080; hsa04725; hsa04810	NA	79.4%
4	DRD2	P14416	D(2) dopamine receptor	hsa04015; hsa04024; hsa04080; hsa04540; hsa04728; hsa05012; hsa05030; hsa05034	1I15; 5AER	76.2%
5	HTR2A	P28223	5-hydroxytryptamine receptor 2A	hsa04020; hsa04080; hsa04540; hsa04726; hsa04750	NA	74.5%
6	HTR1A	P08908	5-hydroxytryptamine receptor 1A	hsa04024; hsa04080; hsa04726; hsa04742	NA	73.1%
7	CHRM5	P08912	Muscarinic acetylcholine receptor M5	hsa04020; hsa04080; hsa04725; hsa04810	NA	72.9%
8	HTR2B	P41595	5-hydroxytryptamine receptor 2B	hsa04020; hsa04080; hsa04540; hsa04726; hsa04750	4IB4; 4NC3	70.6%
9	HTR7	P34969	5-hydroxytryptamine receptor 7	hsa04014; hsa04020; hsa04080; hsa04726	NA	68.1%
10	HTR3A	P46098	5-hydroxytryptamine receptor 3A	hsa04726; hsa04742	NA	67.7%
11	SLC6A3	Q01959	Sodium-dependent dopamine transporter	hsa04728; hsa05012; hsa05030; hsa05031; hsa05034	NA	66.9%
12	HTR1D	P28221	5-hydroxytryptamine receptor 1D	hsa04024; hsa04080; hsa04726; hsa04742	NA	66.0%
13	HTR1B	P28222	5-hydroxytryptamine receptor 1B	hsa04024; hsa04080; hsa04726; hsa04742	2G1X; 4IAQ; 4IAR	65.7%
14	DRD3	P35462	D(3) dopamine receptor	hsa04080; hsa04728	3PBL	63.3%
15	DRD5	P21918	D(1B) dopamine receptor	hsa04020; hsa04024; hsa04080; hsa04728	NA	61.4%
16	DRD1	P21728	D(1A) dopamine receptor	hsa04020; hsa04024; hsa04080; hsa04540; hsa04728; hsa05012; hsa05030; hsa05031; hsa05032; hsa05034	1OZ5	60.7%
17	ADRA2A	P08913	Alpha-2A adrenergic receptor	hsa04022; hsa04080	1HLL; 1HO9; 1HOD; 1HOF	59.2%
18	ADRA2C	P18825	Alpha-2C adrenergic receptor	hsa04022; hsa04080	NA	58.9%
19	SIGMAR1	Q99720	Sigma non-opioid intracellular receptor 1	NA	NA	58.9%
20	HTR1E	P28566	5-hydroxytryptamine receptor 1E	hsa04024; hsa04080; hsa04726; hsa04742	NA	58.2%