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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB00514
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb

22 known interactions (targets) of input drug (DB00514): Dextromethorphan
No. Gene UniProt ID Protein Name Pathway PDB
1 CHRNA4 P43681 Neuronal acetylcholine receptor subunit alpha-4 hsa04080; hsa04725; hsa05033 2GVT; 2LLY
2 SIGMAR1 Q99720 Sigma non-opioid intracellular receptor 1 NA NA
3 OPRD1 P41143 Delta-type opioid receptor hsa04022; hsa04071; hsa04080 1OZC; 2IQM; 4N6H; 4RWA; 4RWD
4 OPRK1 P41145 Kappa-type opioid receptor hsa04080 2A0D; 2IQN; 4DJH
5 CHRNB4 P30926 Neuronal acetylcholine receptor subunit beta-4 hsa04080; hsa04725 2ASG
6 CHRNA7 P36544 Neuronal acetylcholine receptor subunit alpha-7 NA 2MAW; 5AFH; 5AFJ; 5AFK; 5AFL; 5AFM; 5AFN
7 NCF1 P14598 Neutrophil cytosol factor 1 hsa04062; hsa04145; hsa04380; hsa04666; hsa04670; hsa05140; hsa05418 1GD5; 1K4U; 1KQ6; 1NG2; 1O7K; 1OV3; 1UEC; 1W70; 1WLP
8 SLC6A4 P31645 Sodium-dependent serotonin transporter hsa04726 NA
9 GRIN3A Q8TCU5 Glutamate receptor ionotropic, NMDA 3A hsa04024; hsa04080; hsa04724; hsa05030; hsa05031; hsa05033; hsa05034 NA
10 RAC2 P15153 Ras-related C3 botulinum toxin substrate 2 hsa04010; hsa04014; hsa04015; hsa04024; hsa04062; hsa04071; hsa04310; hsa04360; hsa04370; hsa04510; hsa04520; hsa04650; hsa04662; hsa04664; hsa04666; hsa04670; hsa04810; hsa05163; hsa05170; hsa05200; hsa05210; hsa05212; hsa05231; hsa05416; hsa05418 1DS6; 2W2T; 2W2V; 2W2X
11 PGRMC1 O00264 Membrane-associated progesterone receptor component 1 NA NA
12 CHRNA2 Q15822 Neuronal acetylcholine receptor subunit alpha-2 hsa04080 NA
13 NCF4 Q15080 Neutrophil cytosol factor 4 hsa04145; hsa04380; hsa04670; hsa05140 1H6H; 1OEY; 1W6X; 1W70; 1Z9Q; 2DYB
14 CYBA P13498 Cytochrome b-245 light chain hsa04145; hsa04380; hsa04621; hsa04670; hsa05140; hsa05418 1WLP
15 SLC6A2 P23975 Sodium-dependent noradrenaline transporter NA NA
16 CHRNA3 P32297 Neuronal acetylcholine receptor subunit alpha-3 hsa04080; hsa04725 4ZK4
17 CHRNB2 P17787 Neuronal acetylcholine receptor subunit beta-2 hsa04080; hsa04725; hsa05033 2GVT; 2K58; 2K59; 2KSR; 2LM2
18 SIGMAR1 Q5T1J1 HCG20471, isoform CRA_c NA NA
19 CYBB P04839 Cytochrome b-245 heavy chain hsa04066; hsa04145; hsa04216; hsa04217; hsa04621; hsa04670; hsa04933; hsa05140 3A1F
20 OPRM1 P35372 Mu-type opioid receptor hsa04080; hsa04915; hsa05032 NA
21 NCF2 P19878 Neutrophil cytosol factor 2 hsa04145; hsa04380; hsa04670; hsa05140; hsa05418 1E96; 1HH8; 1K4U; 1OEY; 1WM5; 2DMO
22 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 hsa04010; hsa04014; hsa04015; hsa04024; hsa04062; hsa04071; hsa04145; hsa04151; hsa04310; hsa04360; hsa04370; hsa04380; hsa04510; hsa04520; hsa04530; hsa04620; hsa04650; hsa04662; hsa04664; hsa04666; hsa04670; hsa04722; hsa04810; hsa04932; hsa04933; hsa04972; hsa05014; hsa05100; hsa05120; hsa05131; hsa05132; hsa05163; hsa05167; hsa05170; hsa05200; hsa05203; hsa05205; hsa05210; hsa05211; hsa05212; hsa05231; hsa05416; hsa05418

20 predicted interactions (targets) of input drug (DB00514): Dextromethorphan
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 HTR3A P46098 5-hydroxytryptamine receptor 3A hsa04726; hsa04742 NA 67.1%
2 SLC6A3 Q01959 Sodium-dependent dopamine transporter hsa04728; hsa05012; hsa05030; hsa05031; hsa05034 NA 62.5%
3 CHRNA6 Q15825 Neuronal acetylcholine receptor subunit alpha-6 hsa04080; hsa04725; hsa05033 NA 56.2%
4 DRD2 P14416 D(2) dopamine receptor hsa04015; hsa04024; hsa04080; hsa04540; hsa04728; hsa05012; hsa05030; hsa05034 1I15; 5AER 51.4%
5 HTR7 P34969 5-hydroxytryptamine receptor 7 hsa04014; hsa04020; hsa04080; hsa04726 NA 50.2%
6 CHRNA10 Q9GZZ6 Neuronal acetylcholine receptor subunit alpha-10 hsa04080 NA 47.6%
7 HTR2C P28335 5-hydroxytryptamine receptor 2C hsa04020; hsa04080; hsa04540; hsa04726; hsa04750 NA 47.0%
8 ACHE P22303 Acetylcholinesterase hsa00564; hsa04725 1B41; 1F8U; 1PUV; 1PUW; 1VZJ; 2CLJ; 2X8B; 3LII; 4BDT; 4EY4; 4EY5; 4EY6; 4EY7; 4EY8; 4M0E; 4M0F; 4PQE 46.8%
9 HRH1 P35367 Histamine H1 receptor hsa04020; hsa04080; hsa04750 3RZE 46.4%
10 DRD4 P21917 D(4) dopamine receptor hsa04080; hsa04728 NA 44.2%
11 HRH4 Q9H3N8 Histamine H4 receptor hsa04080 NA 43.8%
12 DRD3 P35462 D(3) dopamine receptor hsa04080; hsa04728 3PBL 43.8%
13 CHRM2 P08172 Muscarinic acetylcholine receptor M2 hsa04020; hsa04024; hsa04080; hsa04151; hsa04725; hsa04810 1LUB; 3UON; 4MQS; 4MQT 43.8%
14 HTR2A P28223 5-hydroxytryptamine receptor 2A hsa04020; hsa04080; hsa04540; hsa04726; hsa04750 NA 42.9%
15 CHRM1 P11229 Muscarinic acetylcholine receptor M1 hsa04020; hsa04024; hsa04080; hsa04151; hsa04725; hsa04810 NA 42.2%
16 DRD5 P21918 D(1B) dopamine receptor hsa04020; hsa04024; hsa04080; hsa04728 NA 41.6%
17 SCN10A Q9Y5Y9 Sodium channel protein type 10 subunit alpha NA NA 40.7%
18 LY96 Q9Y6Y9 Lymphocyte antigen 96 hsa04064; hsa04620; hsa05130; hsa05133; hsa05145 1T2Z; 2E56; 2E59; 2Z65; 3FXI; 3ULA; 4G8A 40.0%
19 CHRM4 P08173 Muscarinic acetylcholine receptor M4 hsa04080; hsa04725; hsa04810 NA 39.8%
20 GRIA2 P42262 Glutamate receptor 2 hsa04024; hsa04080; hsa04713; hsa04720; hsa04723; hsa04724; hsa04728; hsa04730; hsa05014; hsa05030; hsa05031; hsa05033 2WJW; 2WJX; 2XHD; 3R7X; 3RN8; 3RNN; 3UA8 39.0%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.