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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P23975
No. Gene UniProt ID Protein Name Pathway PDB
1 SLC6A2 P23975 Sodium-dependent noradrenaline transporter NA NA


67 known interactions (drugs) of input target (SLC6A2): Sodium-dependent noradrenaline transporter
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB00422 Methylphenidate Thumb
2 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb
3 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
4 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb
5 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb
6 Approved;
Illicit		 SmallMoleculeDrug DB00191 Phentermine Thumb
7 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
8 Approved SmallMoleculeDrug DB00344 Protriptyline Thumb
9 Approved;
Illicit		 SmallMoleculeDrug DB00937 Diethylpropion Thumb
10 Approved SmallMoleculeDrug DB00476 Duloxetine Thumb
11 Approved SmallMoleculeDrug DB00226 Guanadrel Thumb
12 Approved;
Illicit		 SmallMoleculeDrug DB01576 Dextroamphetamine Thumb
13 Approved;
Investigational		 SmallMoleculeDrug DB01175 Escitalopram Thumb
14 Approved;
Withdrawn		 SmallMoleculeDrug DB01149 Nefazodone Thumb
15 Illicit;
Withdrawn		 SmallMoleculeDrug DB04836 Amineptine Thumb
16 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
17 Approved SmallMoleculeDrug DB00454 Pethidine Thumb
18 Approved SmallMoleculeDrug DB00988 Dopamine Thumb
19 Approved;
Illicit		 SmallMoleculeDrug DB00830 Phenmetrazine Thumb
20 Approved;
Illicit		 SmallMoleculeDrug DB01577 Methamphetamine Thumb
21 Investigational SmallMoleculeDrug DB06156 Tesofensine Thumb
22 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01242 Clomipramine Thumb
23 Investigational SmallMoleculeDrug DB05688 CRx-119 Thumb
24 Approved SmallMoleculeDrug DB01170 Guanethidine Thumb
25 Approved SmallMoleculeDrug DB00289 Atomoxetine Thumb
26 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
27 Investigational SmallMoleculeDrug DB05012 XEN2174 Thumb
28 Investigational SmallMoleculeDrug DB05642 DDP-225 Thumb
29 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb
30 Approved SmallMoleculeDrug DB01156 Bupropion Thumb
31 Approved;
Illicit		 SmallMoleculeDrug DB00907 Cocaine Thumb
32 Approved SmallMoleculeDrug DB01114 Chlorphenamine Thumb
33 Investigational BiotechDrug DB06333 Trodusquemine Thumb
34 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09225 Zotepine Thumb
35 Investigational SmallMoleculeDrug DB05964 Amitifadine Thumb
36 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09185 Viloxazine Thumb
37 Approved;
Investigational		 SmallMoleculeDrug DB00579 Mazindol Thumb
38 Approved;
Illicit		 SmallMoleculeDrug DB01579 Phendimetrazine Thumb
39 Approved;
Investigational		 SmallMoleculeDrug DB00193 Tramadol Thumb
40 Approved;
Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01105 Sibutramine Thumb
41 Approved SmallMoleculeDrug DB01364 Ephedrine Thumb
42 Approved SmallMoleculeDrug DB00285 Venlafaxine Thumb
43 Withdrawn SmallMoleculeDrug DB04821 Nomifensine Thumb
44 Approved;
Investigational		 SmallMoleculeDrug DB06701 Dexmethylphenidate Thumb
45 Approved SmallMoleculeDrug DB01173 Orphenadrine Thumb
46 Investigational SmallMoleculeDrug DB04889 Bicifadine Thumb
47 Approved;
Investigational		 SmallMoleculeDrug DB04896 Milnacipran Thumb
48 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
49 Experimental;
Illicit		 SmallMoleculeDrug DB01442 MMDA Thumb
50 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb
51 Approved;
Investigational		 SmallMoleculeDrug DB00715 Paroxetine Thumb
52 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
53 Experimental;
Illicit;
Investigational		 SmallMoleculeDrug DB01454 Midomafetamine Thumb
54 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
55 Approved;
Investigational		 SmallMoleculeDrug DB08918 Levomilnacipran Thumb
56 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb
57 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00182 Amphetamine Thumb
58 Approved;
Nutraceutical;
Withdrawn		 SmallMoleculeDrug DB01363 Ephedra Thumb
59 Approved;
Investigational		 SmallMoleculeDrug DB00234 Reboxetine Thumb
60 Approved SmallMoleculeDrug DB06204 Tapentadol Thumb
61 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb
62 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01381 Ginkgo biloba Thumb
63 Approved;
Investigational		 SmallMoleculeDrug DB04840 Debrisoquin Thumb
64 Approved;
Investigational		 SmallMoleculeDrug DB06700 Desvenlafaxine Thumb
65 Investigational SmallMoleculeDrug DB12305 Dasotraline Thumb
66 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
67 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb


20 predicted interactions (drugs) of input target (SLC6A2): Sodium-dependent noradrenaline transporter
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00805 Minaprine Thumb 83.1%
2 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 82.8%
3 Experimental;
Illicit		 SmallMoleculeDrug DB01472 4-Methoxyamphetamine Thumb 80.6%
4 Approved;
Investigational		 SmallMoleculeDrug DB00656 Trazodone Thumb 78.8%
5 Approved SmallMoleculeDrug DB01104 Sertraline Thumb 77.9%
6 Approved;
Investigational		 SmallMoleculeDrug DB09068 Vortioxetine Thumb 77.8%
7 Approved SmallMoleculeDrug DB09195 Lorpiprazole Thumb 76.5%
8 Investigational;
Nutraceutical		 SmallMoleculeDrug DB08839 Serotonin Thumb 76.0%
9 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 74.3%
10 Approved;
Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00574 Fenfluramine Thumb 74.0%
11 Approved SmallMoleculeDrug DB00215 Citalopram Thumb 73.6%
12 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb 73.1%
13 Approved SmallMoleculeDrug DB09016 Butriptyline Thumb 72.2%
14 Approved;
Vet approved		 SmallMoleculeDrug DB00472 Fluoxetine Thumb 71.1%
15 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb 70.8%
16 Approved;
Illicit		 SmallMoleculeDrug DB00865 Benzphetamine Thumb 70.3%
17 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01239 Chlorprothixene Thumb 69.0%
18 Approved;
Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01191 Dexfenfluramine Thumb 68.2%
19 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb 68.0%
20 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb 67.5%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.