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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P08908
No. Gene UniProt ID Protein Name Pathway PDB
1 HTR1A P08908 5-hydroxytryptamine receptor 1A hsa04024; hsa04080; hsa04726; hsa04742 NA


87 known interactions (drugs) of input target (HTR1A): 5-hydroxytryptamine receptor 1A
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb
2 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
3 Investigational SmallMoleculeDrug DB04884 Dapoxetine Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB06016 Cariprazine Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB01359 Penbutolol Thumb
7 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
8 Investigational SmallMoleculeDrug DB06446 Dotarizine Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb
10 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb
11 Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB04829 Lysergic Acid Diethylamide Thumb
12 Approved;
Investigational		 SmallMoleculeDrug DB00960 Pindolol Thumb
13 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb
14 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb
15 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb
16 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb
17 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb
18 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
19 Investigational SmallMoleculeDrug DB12061 Pardoprunox Thumb
20 Approved SmallMoleculeDrug DB06684 Vilazodone Thumb
21 Approved;
Withdrawn		 SmallMoleculeDrug DB00866 Alprenolol Thumb
22 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
23 Approved;
Investigational		 SmallMoleculeDrug DB00656 Trazodone Thumb
24 Approved;
Investigational		 SmallMoleculeDrug DB00490 Buspirone Thumb
25 Approved SmallMoleculeDrug DB09244 Pirlindole Thumb
26 Investigational SmallMoleculeDrug DB05339 MN-305 Thumb
27 Approved SmallMoleculeDrug DB08807 Bopindolol Thumb
28 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb
29 Approved;
Investigational		 SmallMoleculeDrug DB09068 Vortioxetine Thumb
30 Investigational SmallMoleculeDrug DB04970 Lesopitron Thumb
31 Approved SmallMoleculeDrug DB01622 Thioproperazine Thumb
32 Approved;
Investigational		 SmallMoleculeDrug DB08810 Cinitapride Thumb
33 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
34 Approved;
Investigational		 SmallMoleculeDrug DB09128 Brexpiprazole Thumb
35 Investigational SmallMoleculeDrug DB06454 Sarizotan Thumb
36 Approved SmallMoleculeDrug DB08922 Perospirone Thumb
37 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01392 Yohimbine Thumb
38 Approved;
Investigational		 SmallMoleculeDrug DB01621 Pipotiazine Thumb
39 Approved SmallMoleculeDrug DB00988 Dopamine Thumb
40 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
41 Approved;
Investigational		 SmallMoleculeDrug DB04948 Lofexidine Thumb
42 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
43 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb
44 Approved SmallMoleculeDrug DB05271 Rotigotine Thumb
45 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
46 Approved;
Investigational		 SmallMoleculeDrug DB00571 Propranolol Thumb
47 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
48 Investigational SmallMoleculeDrug DB05509 LI-301 Thumb
49 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb
50 Approved;
Investigational		 SmallMoleculeDrug DB00952 Naratriptan Thumb
51 Approved;
Investigational		 SmallMoleculeDrug DB00216 Eletriptan Thumb
52 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
53 Approved;
Withdrawn		 SmallMoleculeDrug DB01149 Nefazodone Thumb
54 Investigational SmallMoleculeDrug DB06393 Xaliproden Thumb
55 Investigational SmallMoleculeDrug DB06538 Robalzotan Thumb
56 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
57 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
58 Investigational SmallMoleculeDrug DB04888 Bifeprunox Thumb
59 Approved SmallMoleculeDrug DB00247 Methysergide Thumb
60 Approved;
Investigational		 SmallMoleculeDrug DB09289 Tianeptine Thumb
61 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
62 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
63 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
64 Approved;
Investigational		 SmallMoleculeDrug DB00413 Pramipexole Thumb
65 Approved;
Investigational		 SmallMoleculeDrug DB04908 Flibanserin Thumb
66 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
67 Experimental;
Illicit		 SmallMoleculeDrug DB14010 5-methoxy-N,N-dimethyltryptamine Thumb
68 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb
69 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb
70 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
71 Investigational SmallMoleculeDrug DB05562 Naluzotan Thumb
72 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb
73 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb
74 Approved;
Investigational		 SmallMoleculeDrug DB08815 Lurasidone Thumb
75 Investigational SmallMoleculeDrug DB06506 Repinotan Thumb
76 Approved SmallMoleculeDrug DB00904 Ondansetron Thumb
77 Investigational SmallMoleculeDrug DB11755 Tetrahydrocannabivarin Thumb
78 Approved;
Vet approved		 SmallMoleculeDrug DB01614 Acepromazine Thumb
79 Approved;
Investigational		 SmallMoleculeDrug DB00315 Zolmitriptan Thumb
80 Approved SmallMoleculeDrug DB01618 Molindone Thumb
81 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb
82 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
83 Approved;
Investigational		 SmallMoleculeDrug DB00669 Sumatriptan Thumb
84 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb
85 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
86 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb
87 Approved;
Investigational		 SmallMoleculeDrug DB01616 Alverine Thumb


20 predicted interactions (drugs) of input target (HTR1A): 5-hydroxytryptamine receptor 1A
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 90.0%
2 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb 86.8%
3 Investigational SmallMoleculeDrug DB06229 Ocaperidone Thumb 86.0%
4 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb 84.5%
5 Approved;
Investigational		 SmallMoleculeDrug DB00751 Epinastine Thumb 82.0%
6 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb 81.8%
7 Approved;
Investigational		 SmallMoleculeDrug DB01069 Promethazine Thumb 81.5%
8 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09225 Zotepine Thumb 80.5%
9 Approved;
Investigational		 SmallMoleculeDrug DB01624 Zuclopenthixol Thumb 80.4%
10 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01239 Chlorprothixene Thumb 79.2%
11 Approved;
Investigational		 SmallMoleculeDrug DB09223 Blonanserin Thumb 77.5%
12 Approved;
Investigational		 SmallMoleculeDrug DB09286 Pipamperone Thumb 77.4%
13 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06144 Sertindole Thumb 77.2%
14 Approved;
Vet approved		 SmallMoleculeDrug DB00420 Promazine Thumb 76.6%
15 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb 74.9%
16 Approved;
Investigational		 SmallMoleculeDrug DB06288 Amisulpride Thumb 74.7%
17 Investigational SmallMoleculeDrug DB06678 Esmirtazapine Thumb 74.3%
18 Approved SmallMoleculeDrug DB00434 Cyproheptadine Thumb 73.6%
19 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb 73.4%
20 Approved;
Investigational		 SmallMoleculeDrug DB00320 Dihydroergotamine Thumb 73.2%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.