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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P25021
No. Gene UniProt ID Protein Name Pathway PDB
1 HRH2 P25021 Histamine H2 receptor hsa04020; hsa04080; hsa04971 NA


18 known interactions (drugs) of input target (HRH2): Histamine H2 receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB08805 Metiamide Thumb
2 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
3 Approved SmallMoleculeDrug DB00927 Famotidine Thumb
4 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
6 Investigational SmallMoleculeDrug DB05369 HZT-501 Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB00751 Epinastine Thumb
8 Approved SmallMoleculeDrug DB00585 Nizatidine Thumb
9 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
10 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb
11 Approved;
Investigational		 SmallMoleculeDrug DB01069 Promethazine Thumb
12 Approved;
Investigational		 SmallMoleculeDrug DB05381 Histamine Thumb
13 Approved;
Vet approved		 SmallMoleculeDrug DB00797 Tolazoline Thumb
14 Approved;
Investigational		 SmallMoleculeDrug DB00501 Cimetidine Thumb
15 Approved;
Investigational		 SmallMoleculeDrug DB00940 Methantheline Thumb
16 Approved SmallMoleculeDrug DB00272 Betazole Thumb
17 Approved SmallMoleculeDrug DB00863 Ranitidine Thumb
18 Approved;
Investigational		 SmallMoleculeDrug DB08806 Roxatidine acetate Thumb


20 predicted interactions (drugs) of input target (HRH2): Histamine H2 receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 73.0%
2 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 70.1%
3 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 70.0%
4 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb 69.6%
5 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 69.0%
6 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb 67.3%
7 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb 64.6%
8 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb 64.0%
9 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb 63.2%
10 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb 62.5%
11 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb 62.1%
12 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb 62.1%
13 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb 61.9%
14 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 61.0%
15 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb 60.7%
16 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb 60.1%
17 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb 60.1%
18 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb 59.8%
19 Approved;
Investigational		 SmallMoleculeDrug DB04948 Lofexidine Thumb 59.6%
20 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb 59.0%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.