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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P08172
No. Gene UniProt ID Protein Name Pathway PDB
1 CHRM2 P08172 Muscarinic acetylcholine receptor M2 hsa04020; hsa04024; hsa04080; hsa04151; hsa04725; hsa04810 1LUB; 3UON; 4MQS; 4MQT

86 known interactions (drugs) of input target (CHRM2): Muscarinic acetylcholine receptor M2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB00434 Cyproheptadine Thumb
2 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
3 Approved SmallMoleculeDrug DB00785 Cryptenamine Thumb
4 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
5 Approved;
SmallMoleculeDrug DB01062 Oxybutynin Thumb
6 Approved;
Vet approved
SmallMoleculeDrug DB09300 Butylscopolamine Thumb
7 Approved SmallMoleculeDrug DB00332 Ipratropium Thumb
8 Approved;
SmallMoleculeDrug DB12278 Propiverine Thumb
9 Withdrawn SmallMoleculeDrug DB04834 Rapacuronium Thumb
10 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb
11 Approved SmallMoleculeDrug DB08897 Aclidinium Thumb
12 Approved;
SmallMoleculeDrug DB01142 Doxepin Thumb
13 Approved;
SmallMoleculeDrug DB00334 Olanzapine Thumb
14 Withdrawn SmallMoleculeDrug DB00767 Benzquinamide Thumb
15 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
16 Approved;
SmallMoleculeDrug DB00622 Nicardipine Thumb
17 Approved SmallMoleculeDrug DB00383 Oxyphencyclimine Thumb
18 Approved SmallMoleculeDrug DB00280 Disopyramide Thumb
19 Approved;
SmallMoleculeDrug DB01239 Chlorprothixene Thumb
20 Approved;
SmallMoleculeDrug DB01231 Diphenidol Thumb
21 Approved SmallMoleculeDrug DB00454 Pethidine Thumb
22 Approved SmallMoleculeDrug DB00835 Brompheniramine Thumb
23 Approved SmallMoleculeDrug DB00202 Succinylcholine Thumb
24 Approved;
SmallMoleculeDrug DB00907 Cocaine Thumb
25 Approved SmallMoleculeDrug DB06702 Fesoterodine Thumb
26 Approved SmallMoleculeDrug DB00411 Carbachol Thumb
27 Approved SmallMoleculeDrug DB03128 Acetylcholine Thumb
28 Approved;
SmallMoleculeDrug DB01238 Aripiprazole Thumb
29 Approved SmallMoleculeDrug DB00462 Methylscopolamine bromide Thumb
30 Approved SmallMoleculeDrug DB01148 Flavoxate Thumb
31 Approved SmallMoleculeDrug DB00424 Hyoscyamine Thumb
32 Approved SmallMoleculeDrug DB00804 Dicyclomine Thumb
33 Approved;
SmallMoleculeDrug DB00555 Lamotrigine Thumb
34 Investigational SmallMoleculeDrug DB05752 ALKS 27 Thumb
35 Approved SmallMoleculeDrug DB01019 Bethanechol Thumb
36 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
37 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb
38 Approved;
SmallMoleculeDrug DB01151 Desipramine Thumb
39 Approved;
SmallMoleculeDrug DB00568 Cinnarizine Thumb
40 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb
41 Approved;
SmallMoleculeDrug DB01085 Pilocarpine Thumb
42 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
43 Approved;
Vet approved
SmallMoleculeDrug DB01221 Ketamine Thumb
44 Approved SmallMoleculeDrug DB00725 Homatropine Methylbromide Thumb
45 Approved;
SmallMoleculeDrug DB00496 Darifenacin Thumb
46 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
47 Approved;
Vet approved
SmallMoleculeDrug DB00508 Triflupromazine Thumb
48 Approved SmallMoleculeDrug DB11235 Thonzylamine Thumb
49 Approved SmallMoleculeDrug DB06787 Hexocyclium Thumb
50 Approved SmallMoleculeDrug DB01409 Tiotropium Thumb
51 Withdrawn SmallMoleculeDrug DB00505 Tridihexethyl Thumb
52 Approved;
SmallMoleculeDrug DB01069 Promethazine Thumb
53 Approved;
Vet approved
SmallMoleculeDrug DB00572 Atropine Thumb
54 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
55 Approved SmallMoleculeDrug DB01337 Pancuronium Thumb
56 Approved;
SmallMoleculeDrug DB09262 Imidafenacin Thumb
57 Approved SmallMoleculeDrug DB00340 Metixene Thumb
58 Approved;
SmallMoleculeDrug DB08801 Dimetindene Thumb
59 Approved;
SmallMoleculeDrug DB01036 Tolterodine Thumb
60 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
61 Approved;
SmallMoleculeDrug DB00934 Maprotiline Thumb
62 Approved SmallMoleculeDrug DB01135 Doxacurium chloride Thumb
63 Approved SmallMoleculeDrug DB01336 Metocurine Thumb
64 Approved;
SmallMoleculeDrug DB01075 Diphenhydramine Thumb
65 Approved SmallMoleculeDrug DB01591 Solifenacin Thumb
66 Approved SmallMoleculeDrug DB00728 Rocuronium Thumb
67 Approved;
SmallMoleculeDrug DB00342 Terfenadine Thumb
68 Approved;
SmallMoleculeDrug DB00809 Tropicamide Thumb
69 Approved SmallMoleculeDrug DB00376 Trihexyphenidyl Thumb
70 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb
71 Approved SmallMoleculeDrug DB00387 Procyclidine Thumb
72 Approved SmallMoleculeDrug DB01226 Mivacurium Thumb
73 Approved SmallMoleculeDrug DB09076 Umeclidinium Thumb
74 Approved SmallMoleculeDrug DB00517 Anisotropine Methylbromide Thumb
75 Approved SmallMoleculeDrug DB01338 Pipecuronium Thumb
76 Approved SmallMoleculeDrug DB11181 Homatropine Thumb
77 Approved;
SmallMoleculeDrug DB00747 Scopolamine Thumb
78 Approved SmallMoleculeDrug DB00483 Gallamine Triethiodide Thumb
79 Approved SmallMoleculeDrug DB00392 Ethopropazine Thumb
80 Approved;
SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
81 Approved;
Vet approved
SmallMoleculeDrug DB00420 Promazine Thumb
82 Approved;
SmallMoleculeDrug DB00715 Paroxetine Thumb
83 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
84 Approved;
Vet approved
SmallMoleculeDrug DB00986 Glycopyrronium Thumb
85 Approved;
SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
86 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb

20 predicted interactions (drugs) of input target (CHRM2): Muscarinic acetylcholine receptor M2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB00193 Tramadol Thumb 93.9%
2 Approved;
Vet approved
SmallMoleculeDrug DB00477 Chlorpromazine Thumb 91.2%
3 Approved;
Vet approved
SmallMoleculeDrug DB01625 Isopropamide Thumb 88.2%
4 Approved SmallMoleculeDrug DB00185 Cevimeline Thumb 83.7%
5 Approved;
SmallMoleculeDrug DB01175 Escitalopram Thumb 83.6%
6 Experimental SmallMoleculeDrug DB04365 Arecoline Thumb 82.9%
7 Approved SmallMoleculeDrug DB04843 Mepenzolate Thumb 82.8%
8 Approved SmallMoleculeDrug DB00805 Minaprine Thumb 82.4%
9 Approved SmallMoleculeDrug DB00215 Citalopram Thumb 81.6%
10 Approved SmallMoleculeDrug DB00354 Buclizine Thumb 81.4%
11 Approved;
SmallMoleculeDrug DB06709 Methacholine Thumb 79.9%
12 Approved;
SmallMoleculeDrug DB00810 Biperiden Thumb 79.9%
13 Approved SmallMoleculeDrug DB00245 Benzatropine Thumb 79.8%
14 Investigational SmallMoleculeDrug DB04924 Itopride Thumb 78.8%
15 Approved;
SmallMoleculeDrug DB00875 Flupentixol Thumb 78.5%
16 Approved;
Vet approved;
SmallMoleculeDrug DB00729 Diphemanil Methylsulfate Thumb 77.6%
17 Approved;
SmallMoleculeDrug DB00940 Methantheline Thumb 77.5%
18 Approved;
Vet approved
SmallMoleculeDrug DB00366 Doxylamine Thumb 77.4%
19 Approved SmallMoleculeDrug DB01618 Molindone Thumb 75.8%
20 Investigational SmallMoleculeDrug DB05766 ACP-104 Thumb 74.1%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.