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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P34969
No. Gene UniProt ID Protein Name Pathway PDB
1 HTR7 P34969 5-hydroxytryptamine receptor 7 hsa04014; hsa04020; hsa04080; hsa04726 NA


37 known interactions (drugs) of input target (HTR7): 5-hydroxytryptamine receptor 7
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb
3 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
4 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB00216 Eletriptan Thumb
6 Approved SmallMoleculeDrug DB00434 Cyproheptadine Thumb
7 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
8 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb
9 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
10 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
11 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
12 Approved;
Investigational		 SmallMoleculeDrug DB06288 Amisulpride Thumb
13 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb
14 Approved SmallMoleculeDrug DB00988 Dopamine Thumb
15 Approved;
Investigational		 SmallMoleculeDrug DB08815 Lurasidone Thumb
16 Approved;
Investigational		 SmallMoleculeDrug DB00751 Epinastine Thumb
17 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb
18 Investigational SmallMoleculeDrug DB13988 SB-269970 Thumb
19 Approved;
Investigational		 SmallMoleculeDrug DB09068 Vortioxetine Thumb
20 Approved SmallMoleculeDrug DB00247 Methysergide Thumb
21 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
22 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
23 Approved SmallMoleculeDrug DB09304 Setiptiline Thumb
24 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb
25 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
26 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
27 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09225 Zotepine Thumb
28 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
29 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
30 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
31 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb
32 Approved;
Investigational		 SmallMoleculeDrug DB04948 Lofexidine Thumb
33 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
34 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
35 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
36 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
37 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb


20 predicted interactions (drugs) of input target (HTR7): 5-hydroxytryptamine receptor 7
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 88.9%
2 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb 88.4%
3 Approved;
Investigational		 SmallMoleculeDrug DB00413 Pramipexole Thumb 87.0%
4 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb 85.8%
5 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb 85.3%
6 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb 85.1%
7 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 84.9%
8 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb 84.1%
9 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb 83.3%
10 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb 82.0%
11 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01239 Chlorprothixene Thumb 80.8%
12 Approved SmallMoleculeDrug DB08922 Perospirone Thumb 80.8%
13 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb 80.7%
14 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 79.5%
15 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb 79.4%
16 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb 78.9%
17 Approved;
Vet approved		 SmallMoleculeDrug DB00420 Promazine Thumb 78.6%
18 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06144 Sertindole Thumb 77.8%
19 Approved;
Withdrawn		 SmallMoleculeDrug DB01149 Nefazodone Thumb 77.7%
20 Approved;
Investigational		 SmallMoleculeDrug DB09286 Pipamperone Thumb 76.3%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.