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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P21728
No. Gene UniProt ID Protein Name Pathway PDB
1 DRD1 P21728 D(1A) dopamine receptor hsa04020; hsa04024; hsa04080; hsa04540; hsa04728; hsa05012; hsa05030; hsa05031; hsa05032; hsa05034 1OZ5


63 known interactions (drugs) of input target (DRD1): D(1A) dopamine receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00623 Fluphenazine Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb
3 Approved;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB00397 Phenylpropanolamine Thumb
4 Approved SmallMoleculeDrug DB00850 Perphenazine Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB00589 Lisuride Thumb
7 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
8 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
9 Approved SmallMoleculeDrug DB01063 Acetophenazine Thumb
10 Approved;
Experimental		 SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
11 Approved SmallMoleculeDrug DB01267 Paliperidone Thumb
12 Approved SmallMoleculeDrug DB11275 Epicriptine Thumb
13 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
14 Investigational SmallMoleculeDrug DB12890 Dihydrexidine Thumb
15 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01239 Chlorprothixene Thumb
16 Withdrawn SmallMoleculeDrug DB00372 Thiethylperazine Thumb
17 Approved;
Investigational		 SmallMoleculeDrug DB01200 Bromocriptine Thumb
18 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
19 Approved;
Withdrawn		 SmallMoleculeDrug DB00679 Thioridazine Thumb
20 Approved;
Vet approved		 SmallMoleculeDrug DB00508 Triflupromazine Thumb
21 Withdrawn SmallMoleculeDrug DB01038 Carphenazine Thumb
22 Approved SmallMoleculeDrug DB00805 Minaprine Thumb
23 Approved;
Investigational		 SmallMoleculeDrug DB09286 Pipamperone Thumb
24 Approved;
Investigational		 SmallMoleculeDrug DB09097 Quinagolide Thumb
25 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
26 Approved SmallMoleculeDrug DB01623 Thiothixene Thumb
27 Approved SmallMoleculeDrug DB04946 Iloperidone Thumb
28 Approved SmallMoleculeDrug DB01622 Thioproperazine Thumb
29 Approved SmallMoleculeDrug DB00502 Haloperidol Thumb
30 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09225 Zotepine Thumb
31 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
32 Approved SmallMoleculeDrug DB01235 Levodopa Thumb
33 Approved;
Vet approved		 SmallMoleculeDrug DB01614 Acepromazine Thumb
34 Approved SmallMoleculeDrug DB11274 Dihydro-alpha-ergocryptine Thumb
35 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb
36 Approved SmallMoleculeDrug DB11584 Pipradrol Thumb
37 Approved SmallMoleculeDrug DB00800 Fenoldopam Thumb
38 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00875 Flupentixol Thumb
39 Approved SmallMoleculeDrug DB05271 Rotigotine Thumb
40 Approved;
Investigational		 SmallMoleculeDrug DB01608 Propericiazine Thumb
41 Approved;
Investigational		 SmallMoleculeDrug DB00734 Risperidone Thumb
42 Approved SmallMoleculeDrug DB00353 Methylergometrine Thumb
43 Approved;
Investigational		 SmallMoleculeDrug DB01621 Pipotiazine Thumb
44 Approved SmallMoleculeDrug DB00988 Dopamine Thumb
45 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
46 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb
47 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
48 Approved;
Vet approved		 SmallMoleculeDrug DB00420 Promazine Thumb
49 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
50 Approved;
Investigational		 SmallMoleculeDrug DB01624 Zuclopenthixol Thumb
51 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
52 Approved;
Investigational		 SmallMoleculeDrug DB00268 Ropinirole Thumb
53 Investigational SmallMoleculeDrug DB12093 Tetrahydropalmatine Thumb
54 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
55 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
56 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
57 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb
58 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB01186 Pergolide Thumb
59 Approved;
Investigational		 SmallMoleculeDrug DB00413 Pramipexole Thumb
60 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
61 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
62 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
63 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb


20 predicted interactions (drugs) of input target (DRD1): D(1A) dopamine receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB13025 Tiapride Thumb 88.9%
2 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 88.8%
3 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb 87.8%
4 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb 84.9%
5 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb 84.7%
6 Approved;
Investigational		 SmallMoleculeDrug DB09128 Brexpiprazole Thumb 84.5%
7 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb 84.2%
8 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb 84.0%
9 Approved;
Investigational		 SmallMoleculeDrug DB08815 Lurasidone Thumb 83.4%
10 Approved;
Investigational		 SmallMoleculeDrug DB06016 Cariprazine Thumb 83.4%
11 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB06144 Sertindole Thumb 82.5%
12 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb 81.2%
13 Approved SmallMoleculeDrug DB08922 Perospirone Thumb 80.4%
14 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb 79.3%
15 Investigational SmallMoleculeDrug DB06229 Ocaperidone Thumb 79.2%
16 Investigational SmallMoleculeDrug DB12061 Pardoprunox Thumb 79.0%
17 Approved;
Investigational		 SmallMoleculeDrug DB06288 Amisulpride Thumb 78.6%
18 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 77.9%
19 Approved SmallMoleculeDrug DB01618 Molindone Thumb 77.7%
20 Approved;
Investigational		 SmallMoleculeDrug DB01069 Promethazine Thumb 77.6%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.