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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P07550
No. Gene UniProt ID Protein Name Pathway PDB
1 ADRB2 P07550 Beta-2 adrenergic receptor hsa04020; hsa04022; hsa04024; hsa04080; hsa04261; hsa04923; hsa04924; hsa04970 1GQ4; 2R4R; 2R4S; 2RH1; 3D4S; 3KJ6; 3NY8; 3NY9; 3NYA; 3P0G; 3PDS; 3SN6; 4GBR; 4LDE; 4LDL; 4LDO; 4QKX

81 known interactions (drugs) of input target (ADRB2): Beta-2 adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
SmallMoleculeDrug DB01274 Arformoterol Thumb
2 Approved SmallMoleculeDrug DB01214 Metipranolol Thumb
3 Approved;
SmallMoleculeDrug DB00571 Propranolol Thumb
4 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
5 Approved;
SmallMoleculeDrug DB00960 Pindolol Thumb
6 Investigational SmallMoleculeDrug DB09204 Arotinolol Thumb
7 Approved;
Vet approved
SmallMoleculeDrug DB01407 Clenbuterol Thumb
8 Approved;
SmallMoleculeDrug DB00867 Ritodrine Thumb
9 Approved SmallMoleculeDrug DB08808 Bupranolol Thumb
10 Approved SmallMoleculeDrug DB01182 Propafenone Thumb
11 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
12 Approved SmallMoleculeDrug DB00368 Norepinephrine Thumb
13 Experimental SmallMoleculeDrug DB03566 Spermidine Thumb
14 Approved;
SmallMoleculeDrug DB04846 Celiprolol Thumb
15 Approved;
SmallMoleculeDrug DB13345 Dihydroergocristine Thumb
16 Approved SmallMoleculeDrug DB09082 Vilanterol Thumb
17 Approved;
Vet approved;
SmallMoleculeDrug DB00397 Phenylpropanolamine Thumb
18 Approved SmallMoleculeDrug DB00248 Cabergoline Thumb
19 Approved;
SmallMoleculeDrug DB04861 Nebivolol Thumb
20 Approved;
SmallMoleculeDrug DB13139 Levosalbutamol Thumb
21 Approved SmallMoleculeDrug DB00521 Carteolol Thumb
22 Withdrawn SmallMoleculeDrug DB00901 Bitolterol Thumb
23 Approved SmallMoleculeDrug DB05039 Indacaterol Thumb
24 Approved SmallMoleculeDrug DB00816 Orciprenaline Thumb
25 Approved;
SmallMoleculeDrug DB01359 Penbutolol Thumb
26 Approved;
SmallMoleculeDrug DB01288 Fenoterol Thumb
27 Approved;
SmallMoleculeDrug DB00195 Betaxolol Thumb
28 Approved;
SmallMoleculeDrug DB01193 Acebutolol Thumb
29 Approved SmallMoleculeDrug DB11587 Etafedrine Thumb
30 Approved;
SmallMoleculeDrug DB00866 Alprenolol Thumb
31 Experimental SmallMoleculeDrug DB09013 Befunolol Thumb
32 Approved SmallMoleculeDrug DB08807 Bopindolol Thumb
33 Approved SmallMoleculeDrug DB01295 Bevantolol Thumb
34 Approved SmallMoleculeDrug DB01365 Mephentermine Thumb
35 Approved;
SmallMoleculeDrug DB00127 Spermine Thumb
36 Approved SmallMoleculeDrug DB01102 Arbutamine Thumb
37 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
38 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb
39 Approved SmallMoleculeDrug DB01210 Levobunolol Thumb
40 Approved SmallMoleculeDrug DB00841 Dobutamine Thumb
41 Approved SmallMoleculeDrug DB09080 Olodaterol Thumb
42 Experimental;
SmallMoleculeDrug DB06726 Bufuralol Thumb
43 Approved SmallMoleculeDrug DB01580 Oxprenolol Thumb
44 Approved;
SmallMoleculeDrug DB09273 Doxofylline Thumb
45 Investigational SmallMoleculeDrug DB12248 Tulobuterol Thumb
46 Approved;
Vet approved
SmallMoleculeDrug DB00668 Epinephrine Thumb
47 Approved;
Vet approved
SmallMoleculeDrug DB06814 Protokylol Thumb
48 Approved SmallMoleculeDrug DB00612 Bisoprolol Thumb
49 Approved SmallMoleculeDrug DB11124 Racepinephrine Thumb
50 Approved SmallMoleculeDrug DB01203 Nadolol Thumb
51 Approved SmallMoleculeDrug DB00871 Terbutaline Thumb
52 Approved;
SmallMoleculeDrug DB01366 Procaterol Thumb
53 Experimental SmallMoleculeDrug DB07543 (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol Thumb
54 Approved SmallMoleculeDrug DB00489 Sotalol Thumb
55 Approved;
SmallMoleculeDrug DB01136 Carvedilol Thumb
56 Approved SmallMoleculeDrug DB00449 Dipivefrin Thumb
57 Approved SmallMoleculeDrug DB00335 Atenolol Thumb
58 Approved;
Vet approved
SmallMoleculeDrug DB01001 Salbutamol Thumb
59 Experimental SmallMoleculeDrug DB01917 Putrescine Thumb
60 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
61 Approved;
SmallMoleculeDrug DB00264 Metoprolol Thumb
62 Approved SmallMoleculeDrug DB06216 Asenapine Thumb
63 Approved SmallMoleculeDrug DB00217 Bethanidine Thumb
64 Approved;
SmallMoleculeDrug DB01064 Isoprenaline Thumb
65 Approved;
SmallMoleculeDrug DB01408 Bambuterol Thumb
66 Approved;
SmallMoleculeDrug DB00983 Formoterol Thumb
67 Approved SmallMoleculeDrug DB11273 Dihydroergocornine Thumb
68 Approved SmallMoleculeDrug DB00938 Salmeterol Thumb
69 Approved SmallMoleculeDrug DB00373 Timolol Thumb
70 Approved SmallMoleculeDrug DB01291 Pirbuterol Thumb
71 Approved SmallMoleculeDrug DB01049 Ergoloid mesylate Thumb
72 Approved SmallMoleculeDrug DB00598 Labetalol Thumb
73 Investigational SmallMoleculeDrug DB05849 NCX 950 Thumb
74 Approved;
SmallMoleculeDrug DB00182 Amphetamine Thumb
75 Approved;
SmallMoleculeDrug DB01363 Ephedra Thumb
76 Approved SmallMoleculeDrug DB11278 DL-Methylephedrine Thumb
77 Approved SmallMoleculeDrug DB00925 Phenoxybenzamine Thumb
78 Approved;
SmallMoleculeDrug DB01151 Desipramine Thumb
79 Approved;
SmallMoleculeDrug DB00334 Olanzapine Thumb
80 Approved;
SmallMoleculeDrug DB06262 Droxidopa Thumb
81 Approved SmallMoleculeDrug DB00221 Isoetarine Thumb

20 predicted interactions (drugs) of input target (ADRB2): Beta-2 adrenergic receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00408 Loxapine Thumb 82.8%
2 Experimental SmallMoleculeDrug DB13781 Xamoterol Thumb 78.4%
3 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 74.5%
4 Approved;
SmallMoleculeDrug DB09068 Vortioxetine Thumb 72.5%
5 Approved SmallMoleculeDrug DB01297 Practolol Thumb 72.2%
6 Experimental SmallMoleculeDrug DB08347 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile Thumb 71.3%
7 Approved;
SmallMoleculeDrug DB09351 Levobetaxolol Thumb 71.2%
8 Approved SmallMoleculeDrug DB00187 Esmolol Thumb 70.5%
9 Approved SmallMoleculeDrug DB00457 Prazosin Thumb 69.2%
10 Experimental SmallMoleculeDrug DB08558 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL Thumb 69.1%
11 Approved;
SmallMoleculeDrug DB00555 Lamotrigine Thumb 67.5%
12 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb 66.9%
13 Approved;
SmallMoleculeDrug DB13025 Tiapride Thumb 65.7%
14 Approved;
SmallMoleculeDrug DB09229 Aranidipine Thumb 65.5%
15 Approved;
SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb 65.2%
16 Approved;
SmallMoleculeDrug DB01238 Aripiprazole Thumb 65.0%
17 Approved SmallMoleculeDrug DB01162 Terazosin Thumb 64.5%
18 Approved;
SmallMoleculeDrug DB01142 Doxepin Thumb 64.5%
19 Approved SmallMoleculeDrug DB11577 Indigotindisulfonic Acid Thumb 64.5%
20 Approved;
Vet approved;
SmallMoleculeDrug DB01186 Pergolide Thumb 64.1%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.