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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9Y5S1
No. Gene UniProt ID Protein Name Pathway PDB
1 TRPV2 Q9Y5S1 Transient receptor potential cation channel subfamily V member 2 hsa04621; hsa04750 2F37


5 known interactions (drugs) of input target (TRPV2): Transient receptor potential cation channel subfamily V member 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB14050 Cannabidivarin Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb
3 Investigational SmallMoleculeDrug DB11755 Tetrahydrocannabivarin Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb
5 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb


20 predicted interactions (drugs) of input target (TRPV2): Transient receptor potential cation channel subfamily V member 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB01744 Camphor Thumb 47.0%
2 Experimental SmallMoleculeDrug DB11345 (S)-camphor Thumb 43.4%
3 Experimental SmallMoleculeDrug DB02955 Ricinoleic Acid Thumb 40.7%
4 Approved SmallMoleculeDrug DB00825 Menthol Thumb 39.1%
5 Approved;
Investigational		 SmallMoleculeDrug DB06155 Rimonabant Thumb 31.6%
6 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb 28.9%
7 Approved;
Investigational		 SmallMoleculeDrug DB00486 Nabilone Thumb 28.5%
8 Approved;
Investigational		 SmallMoleculeDrug DB09288 Propacetamol Thumb 27.5%
9 Approved;
Nutraceutical		 SmallMoleculeDrug DB00132 Alpha-Linolenic Acid Thumb 26.1%
10 Approved;
Illicit		 SmallMoleculeDrug DB00470 Dronabinol Thumb 25.6%
11 Investigational SmallMoleculeDrug DB05885 Seletracetam Thumb 24.9%
12 Approved;
Investigational		 SmallMoleculeDrug DB00193 Tramadol Thumb 24.7%
13 Approved;
Investigational		 SmallMoleculeDrug DB06202 Lasofoxifene Thumb 23.5%
14 Approved;
Investigational		 SmallMoleculeDrug DB00909 Zonisamide Thumb 22.6%
15 Investigational SmallMoleculeDrug DB05077 SLV319 Thumb 21.6%
16 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 21.2%
17 Investigational SmallMoleculeDrug DB05201 V24343 Thumb 20.4%
18 Approved SmallMoleculeDrug DB09086 Eugenol Thumb 19.9%
19 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb 19.8%
20 Approved SmallMoleculeDrug DB04841 Flunarizine Thumb 19.6%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.