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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9UGI6
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNN3 Q9UGI6 Small conductance calcium-activated potassium channel protein 3 hsa04911 NA


3 known interactions (drugs) of input target (KCNN3): Small conductance calcium-activated potassium channel protein 3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb
2 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01110 Miconazole Thumb
3 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00721 Procaine Thumb


20 predicted interactions (drugs) of input target (KCNN3): Small conductance calcium-activated potassium channel protein 3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb 28.4%
2 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 25.6%
3 Approved;
Investigational		 SmallMoleculeDrug DB00393 Nimodipine Thumb 24.6%
4 Approved;
Investigational		 SmallMoleculeDrug DB09236 Lacidipine Thumb 24.4%
5 Approved;
Investigational		 SmallMoleculeDrug DB09238 Manidipine Thumb 23.7%
6 Approved;
Investigational		 SmallMoleculeDrug DB09232 Cilnidipine Thumb 23.5%
7 Investigational;
Withdrawn		 SmallMoleculeDrug DB01388 Mibefradil Thumb 23.2%
8 Experimental SmallMoleculeDrug DB03861 (2r,3r,4s,5r)-2-Acetamido-3,4-Dihydroxy-5-Hydroxymethyl-Piperidinium Thumb 22.4%
9 Approved;
Experimental		 SmallMoleculeDrug DB13746 Bioallethrin Thumb 22.3%
10 Approved SmallMoleculeDrug DB00825 Menthol Thumb 21.6%
11 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 21.4%
12 Approved;
Investigational		 SmallMoleculeDrug DB09231 Benidipine Thumb 21.4%
13 Approved;
Investigational		 SmallMoleculeDrug DB00622 Nicardipine Thumb 20.6%
14 Approved;
Investigational		 SmallMoleculeDrug DB04209 Dequalinium Thumb 20.3%
15 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 19.4%
16 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb 19.2%
17 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00653 Magnesium sulfate Thumb 18.5%
18 Approved;
Investigational		 SmallMoleculeDrug DB12278 Propiverine Thumb 18.1%
19 Approved;
Investigational		 SmallMoleculeDrug DB04920 Clevidipine Thumb 17.9%
20 Approved;
Investigational		 SmallMoleculeDrug DB09229 Aranidipine Thumb 17.6%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.