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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P35869
No. Gene UniProt ID Protein Name Pathway PDB
1 AHR P35869 Aryl hydrocarbon receptor hsa04659; hsa04934 NA


19 known interactions (drugs) of input target (AHR): Aryl hydrocarbon receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB11577 Indigotindisulfonic Acid Thumb
2 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB00393 Nimodipine Thumb
4 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00338 Omeprazole Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB01097 Leflunomide Thumb
6 Investigational SmallMoleculeDrug DB07715 Emodin Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB12328 Cantharidin Thumb
8 Experimental;
Investigational		 SmallMoleculeDrug DB04216 Quercetin Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB08995 Diosmin Thumb
10 Approved;
Investigational		 SmallMoleculeDrug DB00499 Flutamide Thumb
11 Experimental SmallMoleculeDrug DB06732 beta-Naphthoflavone Thumb
12 Investigational SmallMoleculeDrug DB12379 Indirubin Thumb
13 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01404 Ginseng Thumb
14 Approved;
Investigational		 SmallMoleculeDrug DB00379 Mexiletine Thumb
15 Experimental SmallMoleculeDrug DB02052 Indirubin-3'-Monoxime Thumb
16 Approved SmallMoleculeDrug DB01076 Atorvastatin Thumb
17 Experimental SmallMoleculeDrug DB08624 BENZOTHIAZOLE Thumb
18 Investigational SmallMoleculeDrug DB12116 Epigallocatechin Gallate Thumb
19 Investigational SmallMoleculeDrug DB11937 Kynurenic Acid Thumb


20 predicted interactions (drugs) of input target (AHR): Aryl hydrocarbon receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00831 Trifluoperazine Thumb 36.7%
2 Approved SmallMoleculeDrug DB00841 Dobutamine Thumb 36.6%
3 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 34.6%
4 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01110 Miconazole Thumb 34.4%
5 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 34.2%
6 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 33.0%
7 Approved;
Investigational		 SmallMoleculeDrug DB00622 Nicardipine Thumb 32.3%
8 Approved;
Investigational		 SmallMoleculeDrug DB01026 Ketoconazole Thumb 31.5%
9 Investigational SmallMoleculeDrug DB12695 Phenethyl Isothiocyanate Thumb 31.5%
10 Approved;
Withdrawn		 SmallMoleculeDrug DB00761 Potassium Chloride Thumb 31.2%
11 Approved;
Investigational		 SmallMoleculeDrug DB01118 Amiodarone Thumb 31.2%
12 Approved;
Investigational		 SmallMoleculeDrug DB09130 Copper Thumb 30.9%
13 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 30.9%
14 Approved;
Investigational		 SmallMoleculeDrug DB08604 Triclosan Thumb 30.2%
15 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB13953 Estradiol benzoate Thumb 29.3%
16 Approved;
Investigational		 SmallMoleculeDrug DB01014 Balsalazide Thumb 29.3%
17 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb 29.0%
18 Approved SmallMoleculeDrug DB01039 Fenofibrate Thumb 28.8%
19 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 28.7%
20 Approved;
Vet approved		 SmallMoleculeDrug DB00252 Phenytoin Thumb 28.7%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.