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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P35499
No. Gene UniProt ID Protein Name Pathway PDB
1 SCN4A P35499 Sodium channel protein type 4 subunit alpha NA NA


9 known interactions (drugs) of input target (SCN4A): Sodium channel protein type 4 subunit alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00818 Propofol Thumb
2 Approved SmallMoleculeDrug DB13269 Dichlorobenzyl alcohol Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB00909 Zonisamide Thumb
4 Approved;
Vet approved		 SmallMoleculeDrug DB00281 Lidocaine Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB00313 Valproic Acid Thumb
6 Approved;
Withdrawn		 SmallMoleculeDrug DB01195 Flecainide Thumb
7 Approved;
Vet approved		 SmallMoleculeDrug DB00586 Diclofenac Thumb
8 Approved SmallMoleculeDrug DB13154 Parachlorophenol Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB05541 Brivaracetam Thumb


20 predicted interactions (drugs) of input target (SCN4A): Sodium channel protein type 4 subunit alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Investigational SmallMoleculeDrug DB05232 Tetrodotoxin Thumb 48.1%
2 Approved;
Vet approved		 SmallMoleculeDrug DB00252 Phenytoin Thumb 43.6%
3 Approved SmallMoleculeDrug DB01346 Quinidine barbiturate Thumb 39.6%
4 Approved SmallMoleculeDrug DB06218 Lacosamide Thumb 39.3%
5 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 37.9%
6 Approved SmallMoleculeDrug DB00273 Topiramate Thumb 36.0%
7 Approved;
Illicit		 SmallMoleculeDrug DB00907 Cocaine Thumb 35.0%
8 Approved SmallMoleculeDrug DB01595 Nitrazepam Thumb 33.7%
9 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 33.5%
10 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 33.0%
11 Approved;
Investigational		 SmallMoleculeDrug DB00243 Ranolazine Thumb 31.0%
12 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb 30.9%
13 Approved SmallMoleculeDrug DB00292 Etomidate Thumb 30.6%
14 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb 30.6%
15 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 29.5%
16 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01381 Ginkgo biloba Thumb 29.2%
17 Approved;
Illicit		 SmallMoleculeDrug DB01215 Estazolam Thumb 28.4%
18 Approved SmallMoleculeDrug DB00280 Disopyramide Thumb 28.2%
19 Approved;
Vet approved		 SmallMoleculeDrug DB01236 Sevoflurane Thumb 28.1%
20 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb 28.1%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.