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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P34903
No. Gene UniProt ID Protein Name Pathway PDB
1 GABRA3 P34903 Gamma-aminobutyric acid receptor subunit alpha-3 hsa04080; hsa04723; hsa04727; hsa04742; hsa05032; hsa05033 NA


73 known interactions (drugs) of input target (GABRA3): Gamma-aminobutyric acid receptor subunit alpha-3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00818 Propofol Thumb
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB01956 Taurine Thumb
3 Approved;
Illicit		 SmallMoleculeDrug DB01352 Aprobarbital Thumb
4 Approved;
Illicit		 SmallMoleculeDrug DB01589 Quazepam Thumb
5 Approved;
Illicit		 SmallMoleculeDrug DB01588 Prazepam Thumb
6 Investigational SmallMoleculeDrug DB13994 AZD-7325 Thumb
7 Withdrawn SmallMoleculeDrug DB00463 Metharbital Thumb
8 Approved SmallMoleculeDrug DB09166 Etizolam Thumb
9 Investigational SmallMoleculeDrug DB06579 Adipiplon Thumb
10 Approved;
Investigational		 SmallMoleculeDrug DB11901 Apalutamide Thumb
11 Approved;
Illicit		 SmallMoleculeDrug DB01567 Fludiazepam Thumb
12 Approved SmallMoleculeDrug DB01355 Hexobarbital Thumb
13 Approved SmallMoleculeDrug DB01189 Desflurane Thumb
14 Investigational SmallMoleculeDrug DB05087 Ganaxolone Thumb
15 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00312 Pentobarbital Thumb
16 Approved;
Illicit		 SmallMoleculeDrug DB01215 Estazolam Thumb
17 Approved SmallMoleculeDrug DB00425 Zolpidem Thumb
18 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
19 Approved;
Illicit;
Withdrawn		 SmallMoleculeDrug DB00801 Halazepam Thumb
20 Approved;
Illicit		 SmallMoleculeDrug DB00237 Butabarbital Thumb
21 Approved SmallMoleculeDrug DB01594 Cinolazepam Thumb
22 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01028 Methoxyflurane Thumb
23 Illicit SmallMoleculeDrug DB01483 Barbital Thumb
24 Approved;
Illicit		 SmallMoleculeDrug DB01559 Clotiazepam Thumb
25 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00228 Enflurane Thumb
26 Approved SmallMoleculeDrug DB00546 Adinazolam Thumb
27 Approved;
Illicit		 SmallMoleculeDrug DB00349 Clobazam Thumb
28 Approved;
Illicit		 SmallMoleculeDrug DB00683 Midazolam Thumb
29 Approved;
Illicit		 SmallMoleculeDrug DB00241 Butalbital Thumb
30 Approved;
Vet approved		 SmallMoleculeDrug DB00418 Secobarbital Thumb
31 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00475 Chlordiazepoxide Thumb
32 Approved;
Vet approved		 SmallMoleculeDrug DB00794 Primidone Thumb
33 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb
34 Approved SmallMoleculeDrug DB00849 Methylphenobarbital Thumb
35 Approved SmallMoleculeDrug DB00842 Oxazepam Thumb
36 Approved;
Investigational		 SmallMoleculeDrug DB00897 Triazolam Thumb
37 Approved;
Investigational		 SmallMoleculeDrug DB00659 Acamprosate Thumb
38 Approved SmallMoleculeDrug DB01354 Heptabarbital Thumb
39 Approved;
Illicit		 SmallMoleculeDrug DB00628 Clorazepate Thumb
40 Approved SmallMoleculeDrug DB13872 Lormetazepam Thumb
41 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb
42 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB01558 Bromazepam Thumb
43 Approved;
Illicit		 SmallMoleculeDrug DB01544 Flunitrazepam Thumb
44 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00404 Alprazolam Thumb
45 Approved;
Vet approved		 SmallMoleculeDrug DB00599 Thiopental Thumb
46 Approved SmallMoleculeDrug DB09118 Stiripentol Thumb
47 Approved;
Vet approved		 SmallMoleculeDrug DB01236 Sevoflurane Thumb
48 Experimental;
Illicit		 SmallMoleculeDrug DB01496 Barbituric acid derivative Thumb
49 Approved SmallMoleculeDrug DB00273 Topiramate Thumb
50 Approved SmallMoleculeDrug DB00292 Etomidate Thumb
51 Approved;
Investigational		 SmallMoleculeDrug DB00402 Eszopiclone Thumb
52 Approved;
Illicit;
Withdrawn		 SmallMoleculeDrug DB00189 Ethchlorvynol Thumb
53 Approved SmallMoleculeDrug DB00186 Lorazepam Thumb
54 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb
55 Approved SmallMoleculeDrug DB01198 Zopiclone Thumb
56 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb
57 Investigational SmallMoleculeDrug DB04903 Pagoclone Thumb
58 Approved;
Investigational		 SmallMoleculeDrug DB00231 Temazepam Thumb
59 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00690 Flurazepam Thumb
60 Approved;
Investigational		 SmallMoleculeDrug DB11582 Thiocolchicoside Thumb
61 Approved;
Illicit		 SmallMoleculeDrug DB01068 Clonazepam Thumb
62 Approved;
Illicit		 SmallMoleculeDrug DB01353 Butethal Thumb
63 Experimental SmallMoleculeDrug DB13983 5,7,2′-trihydroxy-6,8-dimethoxyflavone Thumb
64 Approved;
Illicit		 SmallMoleculeDrug DB01437 Glutethimide Thumb
65 Approved;
Illicit		 SmallMoleculeDrug DB00371 Meprobamate Thumb
66 Approved SmallMoleculeDrug DB01595 Nitrazepam Thumb
67 Approved;
Illicit;
Investigational;
Vet approved		 SmallMoleculeDrug DB00829 Diazepam Thumb
68 Approved SmallMoleculeDrug DB01205 Flumazenil Thumb
69 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
70 Approved;
Illicit;
Withdrawn		 SmallMoleculeDrug DB01107 Methyprylon Thumb
71 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
72 Approved;
Illicit		 SmallMoleculeDrug DB01351 Amobarbital Thumb
73 Approved;
Illicit		 SmallMoleculeDrug DB00306 Talbutal Thumb


20 predicted interactions (drugs) of input target (GABRA3): Gamma-aminobutyric acid receptor subunit alpha-3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB01346 Quinidine barbiturate Thumb 89.0%
2 Approved SmallMoleculeDrug DB01587 Ketazolam Thumb 88.2%
3 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01381 Ginkgo biloba Thumb 85.1%
4 Approved SmallMoleculeDrug DB00395 Carisoprodol Thumb 83.2%
5 Investigational SmallMoleculeDrug DB12458 Muscimol Thumb 82.5%
6 Experimental SmallMoleculeDrug DB00466 Picrotoxin Thumb 77.9%
7 Approved;
Withdrawn		 SmallMoleculeDrug DB00431 Lindane Thumb 75.2%
8 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00962 Zaleplon Thumb 73.5%
9 Approved;
Investigational		 SmallMoleculeDrug DB01174 Phenobarbital Thumb 71.9%
10 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB06716 Fospropofol Thumb 70.4%
11 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00602 Ivermectin Thumb 69.8%
12 Approved;
Investigational		 SmallMoleculeDrug DB00837 Progabide Thumb 66.9%
13 Approved;
Vet approved		 SmallMoleculeDrug DB00592 Piperazine Thumb 66.8%
14 Investigational SmallMoleculeDrug DB06470 clomethiazole Thumb 66.7%
15 Experimental SmallMoleculeDrug DB01341 Dihydroquinidine barbiturate Thumb 65.0%
16 Approved SmallMoleculeDrug DB00474 Methohexital Thumb 61.7%
17 Approved;
Vet approved		 SmallMoleculeDrug DB01154 Thiamylal Thumb 61.0%
18 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB01440 Gamma Hydroxybutyric Acid Thumb 59.4%
19 Approved;
Vet approved		 SmallMoleculeDrug DB00572 Atropine Thumb 39.4%
20 Experimental SmallMoleculeDrug DB02999 Quisqualate Thumb 38.7%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.