QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: O95069
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNK2 O95069 Potassium channel subfamily K member 2 hsa04927; hsa04934; hsa04971 4TWK


2 known interactions (drugs) of input target (KCNK2): Potassium channel subfamily K member 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB00204 Dofetilide Thumb


20 predicted interactions (drugs) of input target (KCNK2): Potassium channel subfamily K member 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 34.6%
2 Approved;
Investigational		 SmallMoleculeDrug DB09229 Aranidipine Thumb 33.5%
3 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb 30.8%
4 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb 30.2%
5 Approved;
Investigational		 SmallMoleculeDrug DB01118 Amiodarone Thumb 29.1%
6 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01392 Yohimbine Thumb 28.5%
7 Approved SmallMoleculeDrug DB00825 Menthol Thumb 28.3%
8 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb 25.7%
9 Approved SmallMoleculeDrug DB00590 Doxazosin Thumb 25.6%
10 Approved;
Investigational		 SmallMoleculeDrug DB11633 Isavuconazole Thumb 25.1%
11 Investigational;
Withdrawn		 SmallMoleculeDrug DB01388 Mibefradil Thumb 24.8%
12 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb 24.3%
13 Approved SmallMoleculeDrug DB00457 Prazosin Thumb 24.3%
14 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb 24.1%
15 Approved;
Investigational		 SmallMoleculeDrug DB06712 Nilvadipine Thumb 23.0%
16 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 22.4%
17 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb 22.1%
18 Approved;
Investigational		 SmallMoleculeDrug DB09232 Cilnidipine Thumb 21.8%
19 Approved;
Nutraceutical		 SmallMoleculeDrug DB01373 Calcium Thumb 21.8%
20 Approved;
Investigational		 SmallMoleculeDrug DB00714 Apomorphine Thumb 21.3%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.