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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q14524
No. Gene UniProt ID Protein Name Pathway PDB
1 SCN5A Q14524 Sodium channel protein type 5 subunit alpha hsa04261 2KBI; 2L53; 4DCK; 4DJC; 4JQ0; 4OVN


34 known interactions (drugs) of input target (SCN5A): Sodium channel protein type 5 subunit alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00680 Moricizine Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB00740 Riluzole Thumb
3 Approved;
Withdrawn		 SmallMoleculeDrug DB00473 Hexylcaine Thumb
4 Investigational;
Withdrawn		 SmallMoleculeDrug DB00532 Mephenytoin Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB11633 Isavuconazole Thumb
6 Approved SmallMoleculeDrug DB01182 Propafenone Thumb
7 Approved SmallMoleculeDrug DB00280 Disopyramide Thumb
8 Approved SmallMoleculeDrug DB01035 Procainamide Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB01320 Fosphenytoin Thumb
10 Approved;
Vet approved		 SmallMoleculeDrug DB00527 Cinchocaine Thumb
11 Approved SmallMoleculeDrug DB00661 Verapamil Thumb
12 Approved SmallMoleculeDrug DB00776 Oxcarbazepine Thumb
13 Approved SmallMoleculeDrug DB01056 Tocainide Thumb
14 Approved;
Investigational		 SmallMoleculeDrug DB00379 Mexiletine Thumb
15 Approved SmallMoleculeDrug DB00754 Ethotoin Thumb
16 Approved;
Investigational		 SmallMoleculeDrug DB00564 Carbamazepine Thumb
17 Approved;
Investigational		 SmallMoleculeDrug DB05541 Brivaracetam Thumb
18 Approved;
Investigational		 SmallMoleculeDrug DB06217 Vernakalant Thumb
19 Approved SmallMoleculeDrug DB13269 Dichlorobenzyl alcohol Thumb
20 Approved;
Illicit		 SmallMoleculeDrug DB00907 Cocaine Thumb
21 Approved SmallMoleculeDrug DB00750 Prilocaine Thumb
22 Approved SmallMoleculeDrug DB01346 Quinidine barbiturate Thumb
23 Approved SmallMoleculeDrug DB00868 Benzonatate Thumb
24 Approved;
Withdrawn		 SmallMoleculeDrug DB01195 Flecainide Thumb
25 Approved;
Vet approved		 SmallMoleculeDrug DB00281 Lidocaine Thumb
26 Approved SmallMoleculeDrug DB01429 Aprindine Thumb
27 Approved;
Investigational		 SmallMoleculeDrug DB01426 Ajmaline Thumb
28 Approved;
Investigational		 SmallMoleculeDrug DB00243 Ranolazine Thumb
29 Approved;
Investigational		 SmallMoleculeDrug DB00909 Zonisamide Thumb
30 Approved SmallMoleculeDrug DB00192 Indecainide Thumb
31 Approved;
Investigational		 SmallMoleculeDrug DB00313 Valproic Acid Thumb
32 Approved;
Investigational		 SmallMoleculeDrug DB00908 Quinidine Thumb
33 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01228 Encainide Thumb
34 Approved;
Vet approved		 SmallMoleculeDrug DB00252 Phenytoin Thumb


20 predicted interactions (drugs) of input target (SCN5A): Sodium channel protein type 5 subunit alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 51.9%
2 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 45.7%
3 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 45.5%
4 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 44.6%
5 Approved SmallMoleculeDrug DB06218 Lacosamide Thumb 42.0%
6 Approved;
Investigational		 SmallMoleculeDrug DB00583 L-Carnitine Thumb 40.7%
7 Approved;
Nutraceutical		 SmallMoleculeDrug DB00139 Succinic acid Thumb 40.4%
8 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01110 Miconazole Thumb 39.5%
9 Approved SmallMoleculeDrug DB04841 Flunarizine Thumb 38.1%
10 Approved;
Investigational		 SmallMoleculeDrug DB01118 Amiodarone Thumb 37.6%
11 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb 37.3%
12 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb 36.8%
13 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 36.6%
14 Approved;
Investigational		 SmallMoleculeDrug DB09238 Manidipine Thumb 34.9%
15 Approved SmallMoleculeDrug DB01211 Clarithromycin Thumb 34.9%
16 Approved SmallMoleculeDrug DB00590 Doxazosin Thumb 34.6%
17 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb 34.2%
18 Approved SmallMoleculeDrug DB00489 Sotalol Thumb 33.3%
19 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00721 Procaine Thumb 33.0%
20 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 32.5%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.