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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P08235
No. Gene UniProt ID Protein Name Pathway PDB
1 NR3C2 P08235 Mineralocorticoid receptor hsa04960 1Y9R; 1YA3; 2A3I; 2AA2; 2AA5; 2AA6; 2AA7; 2AAX; 2AB2; 2ABI; 2OAX; 3VHU; 3VHV; 3WFF; 3WFG; 4PF3; 4TNT


19 known interactions (drugs) of input target (NR3C2): Mineralocorticoid receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB13944 Testosterone enanthate Thumb
2 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb
3 Approved SmallMoleculeDrug DB06780 Desoxycorticosterone acetate Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB01023 Felodipine Thumb
5 Approved;
Vet approved		 SmallMoleculeDrug DB00396 Progesterone Thumb
6 Approved SmallMoleculeDrug DB00588 Fluticasone propionate Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB00624 Testosterone Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB00393 Nimodipine Thumb
9 Experimental;
Investigational		 SmallMoleculeDrug DB04630 Aldosterone Thumb
10 Approved SmallMoleculeDrug DB00700 Eplerenone Thumb
11 Illicit;
Investigational		 SmallMoleculeDrug DB02901 Stanolone Thumb
12 Experimental SmallMoleculeDrug DB04652 Corticosterone Thumb
13 Experimental SmallMoleculeDrug DB02998 Methyltrienolone Thumb
14 Experimental;
Vet approved		 SmallMoleculeDrug DB01134 Desoxycorticosterone Pivalate Thumb
15 Approved SmallMoleculeDrug DB01395 Drospirenone Thumb
16 Experimental SmallMoleculeDrug DB13951 Stanolone acetate Thumb
17 Approved;
Investigational		 SmallMoleculeDrug DB13946 Testosterone undecanoate Thumb
18 Approved;
Investigational		 SmallMoleculeDrug DB00687 Fludrocortisone Thumb
19 Approved SmallMoleculeDrug DB13943 Testosterone cypionate Thumb


20 predicted interactions (drugs) of input target (NR3C2): Mineralocorticoid receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00367 Levonorgestrel Thumb 48.3%
2 Approved;
Experimental		 SmallMoleculeDrug DB13746 Bioallethrin Thumb 48.0%
3 Approved SmallMoleculeDrug DB11619 Gestrinone Thumb 43.8%
4 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 42.3%
5 Approved SmallMoleculeDrug DB09086 Eugenol Thumb 40.4%
6 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 40.1%
7 Approved SmallMoleculeDrug DB01406 Danazol Thumb 38.9%
8 Approved;
Investigational		 SmallMoleculeDrug DB11064 Homosalate Thumb 38.7%
9 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb 38.5%
10 Approved;
Investigational		 SmallMoleculeDrug DB00957 Norgestimate Thumb 37.5%
11 Approved;
Investigational		 SmallMoleculeDrug DB06713 Norelgestromin Thumb 37.3%
12 Approved;
Investigational		 SmallMoleculeDrug DB09231 Benidipine Thumb 36.6%
13 Approved SmallMoleculeDrug DB08867 Ulipristal Thumb 35.9%
14 Approved SmallMoleculeDrug DB09389 Norgestrel Thumb 35.9%
15 Approved SmallMoleculeDrug DB01428 Oxybenzone Thumb 35.0%
16 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb 34.6%
17 Approved;
Investigational		 SmallMoleculeDrug DB09232 Cilnidipine Thumb 34.3%
18 Approved;
Withdrawn		 SmallMoleculeDrug DB01244 Bepridil Thumb 34.1%
19 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb 34.1%
20 Approved SmallMoleculeDrug DB11219 Enzacamene Thumb 33.7%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.