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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q9Y257
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNK6 Q9Y257 Potassium channel subfamily K member 6 NA NA

2 known interactions (drugs) of input target (KCNK6): Potassium channel subfamily K member 6
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
SmallMoleculeDrug DB00908 Quinidine Thumb
2 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb

20 predicted interactions (drugs) of input target (KCNK6): Potassium channel subfamily K member 6
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 32.8%
2 Approved;
SmallMoleculeDrug DB11148 Butamben Thumb 30.0%
3 Approved SmallMoleculeDrug DB00590 Doxazosin Thumb 26.9%
4 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 26.5%
5 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 26.3%
6 Approved SmallMoleculeDrug DB01346 Quinidine barbiturate Thumb 25.7%
7 Approved;
SmallMoleculeDrug DB04842 Fluspirilene Thumb 22.3%
8 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb 22.0%
9 Approved SmallMoleculeDrug DB01162 Terazosin Thumb 21.6%
10 Approved;
Vet approved
SmallMoleculeDrug DB01110 Miconazole Thumb 21.4%
11 Approved;
SmallMoleculeDrug DB01244 Bepridil Thumb 21.0%
12 Approved;
SmallMoleculeDrug DB00622 Nicardipine Thumb 20.6%
13 Approved SmallMoleculeDrug DB00457 Prazosin Thumb 20.3%
14 Approved;
Vet approved
SmallMoleculeDrug DB00472 Fluoxetine Thumb 20.0%
15 Approved;
Vet approved
SmallMoleculeDrug DB00653 Magnesium sulfate Thumb 19.9%
16 Approved;
SmallMoleculeDrug DB01118 Amiodarone Thumb 19.3%
17 Approved;
SmallMoleculeDrug DB11633 Isavuconazole Thumb 18.8%
18 Approved SmallMoleculeDrug DB00489 Sotalol Thumb 18.8%
19 Approved;
SmallMoleculeDrug DB12278 Propiverine Thumb 18.7%
20 Approved;
SmallMoleculeDrug DB06712 Nilvadipine Thumb 18.4%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.