QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P02585
No. Gene UniProt ID Protein Name Pathway PDB
1 TNNC2 P02585 Troponin C, skeletal muscle hsa04020 NA


3 known interactions (drugs) of input target (TNNC2): Troponin C, skeletal muscle
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB01373 Calcium Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB01023 Felodipine Thumb
3 Experimental SmallMoleculeDrug DB04682 Octylphenoxy polyethoxyethanol Thumb


20 predicted interactions (drugs) of input target (TNNC2): Troponin C, skeletal muscle
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Withdrawn		 SmallMoleculeDrug DB01244 Bepridil Thumb 38.9%
2 Approved;
Investigational		 SmallMoleculeDrug DB00622 Nicardipine Thumb 34.9%
3 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 30.7%
4 Approved;
Investigational		 SmallMoleculeDrug DB00270 Isradipine Thumb 30.4%
5 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb 28.2%
6 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 28.1%
7 Approved;
Investigational		 SmallMoleculeDrug DB06712 Nilvadipine Thumb 27.4%
8 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 26.6%
9 Approved SmallMoleculeDrug DB00401 Nisoldipine Thumb 26.2%
10 Approved;
Investigational		 SmallMoleculeDrug DB01054 Nitrendipine Thumb 25.2%
11 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb 24.4%
12 Approved;
Investigational		 SmallMoleculeDrug DB08872 Gabapentin Enacarbil Thumb 24.2%
13 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb 23.9%
14 Approved;
Investigational		 SmallMoleculeDrug DB09231 Benidipine Thumb 23.1%
15 Approved;
Experimental		 SmallMoleculeDrug DB13746 Bioallethrin Thumb 22.7%
16 Approved;
Investigational		 SmallMoleculeDrug DB00393 Nimodipine Thumb 22.1%
17 Approved;
Nutraceutical		 SmallMoleculeDrug DB00142 Glutamic Acid Thumb 21.9%
18 Approved SmallMoleculeDrug DB00825 Menthol Thumb 21.2%
19 Approved;
Investigational		 SmallMoleculeDrug DB09236 Lacidipine Thumb 20.9%
20 Approved;
Investigational		 SmallMoleculeDrug DB01118 Amiodarone Thumb 20.0%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.