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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P22748
No. Gene UniProt ID Protein Name Pathway PDB
1 CA4 P22748 Carbonic anhydrase 4 hsa00910; hsa04964 1ZNC; 3F7B; 3F7U; 3FW3

16 known interactions (drugs) of input target (CA4): Carbonic anhydrase 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB00436 Bendroflumethiazide Thumb
2 Approved SmallMoleculeDrug DB00703 Methazolamide Thumb
3 Approved SmallMoleculeDrug DB01194 Brinzolamide Thumb
4 Approved;
SmallMoleculeDrug DB00909 Zonisamide Thumb
5 Approved SmallMoleculeDrug DB00232 Methyclothiazide Thumb
6 Approved SmallMoleculeDrug DB09460 Sodium carbonate Thumb
7 Approved SmallMoleculeDrug DB00562 Benzthiazide Thumb
8 Approved;
Vet approved
SmallMoleculeDrug DB01021 Trichlormethiazide Thumb
9 Approved;
SmallMoleculeDrug DB00774 Hydroflumethiazide Thumb
10 Approved SmallMoleculeDrug DB00869 Dorzolamide Thumb
11 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb
12 Approved SmallMoleculeDrug DB00273 Topiramate Thumb
13 Approved SmallMoleculeDrug DB00606 Cyclothiazide Thumb
14 Approved;
SmallMoleculeDrug DB01144 Diclofenamide Thumb
15 Withdrawn SmallMoleculeDrug DB00311 Ethoxzolamide Thumb
16 Approved;
Vet approved
SmallMoleculeDrug DB00819 Acetazolamide Thumb

20 predicted interactions (drugs) of input target (CA4): Carbonic anhydrase 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB01119 Diazoxide Thumb 62.1%
2 Approved;
Vet approved
SmallMoleculeDrug DB00999 Hydrochlorothiazide Thumb 58.5%
3 Experimental SmallMoleculeDrug DB08155 N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE Thumb 56.5%
4 Approved SmallMoleculeDrug DB01325 Quinethazone Thumb 55.5%
5 Approved;
Vet approved
SmallMoleculeDrug DB00880 Chlorothiazide Thumb 53.5%
6 Approved;
SmallMoleculeDrug DB01031 Ethinamate Thumb 53.1%
7 Experimental SmallMoleculeDrug DB08157 ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE Thumb 53.1%
8 Approved;
SmallMoleculeDrug DB00482 Celecoxib Thumb 50.2%
9 Approved;
Vet approved
SmallMoleculeDrug DB09472 Sodium sulfate Thumb 50.1%
10 Approved;
Vet approved
SmallMoleculeDrug DB00423 Methocarbamol Thumb 49.1%
11 Experimental SmallMoleculeDrug DB08156 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID Thumb 48.1%
12 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb 47.0%
13 Approved;
SmallMoleculeDrug DB00391 Sulpiride Thumb 44.4%
14 Approved;
SmallMoleculeDrug DB00580 Valdecoxib Thumb 43.0%
15 Investigational SmallMoleculeDrug DB12418 Saccharin Thumb 40.9%
16 Approved;
SmallMoleculeDrug DB01942 Formic Acid Thumb 37.0%
17 Experimental SmallMoleculeDrug DB04763 1-N-(4-SULFAMOYLPHENYL-ETHYL)-2,4,6-TRIMETHYLPYRIDINIUM Thumb 33.5%
18 Approved;
Vet approved
SmallMoleculeDrug DB00695 Furosemide Thumb 33.2%
19 Experimental SmallMoleculeDrug DB03526 AL5927 Thumb 32.5%
20 Experimental SmallMoleculeDrug DB03385 4-Methylimidazole Thumb 31.2%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.