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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.


48 known interactions (drugs) of input target (SRC): Proto-oncogene tyrosine-protein kinase Src
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB01962 Phosphonotyrosine Thumb
2 Experimental SmallMoleculeDrug DB03268 RU82197 Thumb
3 Experimental SmallMoleculeDrug DB07662 N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE Thumb
4 Experimental SmallMoleculeDrug DB03712 RU85053 Thumb
5 Experimental SmallMoleculeDrug DB03306 RU78300 Thumb
6 Experimental SmallMoleculeDrug DB03525 RU79073 Thumb
7 Approved SmallMoleculeDrug DB09079 Nintedanib Thumb
8 Experimental SmallMoleculeDrug DB08053 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Thumb
9 Experimental SmallMoleculeDrug DB03078 PASBN Thumb
10 Experimental SmallMoleculeDrug DB02908 RU78783 Thumb
11 Experimental SmallMoleculeDrug DB03828 RU78299 Thumb
12 Experimental SmallMoleculeDrug DB03298 Phenylphosphate Thumb
13 Experimental SmallMoleculeDrug DB04495 RU81843 Thumb
14 Experimental SmallMoleculeDrug DB03902 Oxalic Acid Thumb
15 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB04272 Citric Acid Thumb
16 Experimental SmallMoleculeDrug DB03628 ISO24 Thumb
17 Experimental SmallMoleculeDrug DB06883 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea Thumb
18 Experimental SmallMoleculeDrug DB04739 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE Thumb
19 Experimental SmallMoleculeDrug DB03591 RU82209 Thumb
20 Experimental SmallMoleculeDrug DB03023 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Thumb
21 Experimental SmallMoleculeDrug DB02336 RU83876 Thumb
22 Experimental SmallMoleculeDrug DB01908 RU85493 Thumb
23 Experimental SmallMoleculeDrug DB04751 Purvalanol A Thumb
24 Investigational SmallMoleculeDrug DB06137 KX-01 Thumb
25 Approved;
Investigational		 SmallMoleculeDrug DB01254 Dasatinib Thumb
26 Experimental SmallMoleculeDrug DB04080 RU78191 Thumb
27 Approved SmallMoleculeDrug DB06616 Bosutinib Thumb
28 Experimental SmallMoleculeDrug DB08052 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Thumb
29 Experimental SmallMoleculeDrug DB08462 N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE Thumb
30 Experimental SmallMoleculeDrug DB02762 RU79072 Thumb
31 Experimental SmallMoleculeDrug DB02175 Malonic acid Thumb
32 Experimental SmallMoleculeDrug DB03217 DPI59 Thumb
33 Experimental SmallMoleculeDrug DB06882 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea Thumb
34 Experimental SmallMoleculeDrug DB07335 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL Thumb
35 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb
36 Experimental SmallMoleculeDrug DB03114 PAS219 Thumb
37 Experimental SmallMoleculeDrug DB08192 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE Thumb
38 Experimental SmallMoleculeDrug DB01893 N6-Benzyl Adenosine-5'-Diphosphate Thumb
39 Experimental SmallMoleculeDrug DB01947 RU78262 Thumb
40 Investigational SmallMoleculeDrug DB05184 XL228 Thumb
41 Experimental SmallMoleculeDrug DB02432 RU90395 Thumb
42 Experimental SmallMoleculeDrug DB08054 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine Thumb
43 Experimental SmallMoleculeDrug DB01866 RU79256 Thumb
44 Experimental SmallMoleculeDrug DB07966 [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile Thumb
45 Experimental SmallMoleculeDrug DB08564 (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide Thumb
46 Experimental SmallMoleculeDrug DB01678 RU84687 Thumb
47 Approved;
Investigational		 SmallMoleculeDrug DB08901 Ponatinib Thumb
48 Experimental SmallMoleculeDrug DB03104 RU82129 Thumb


20 predicted interactions (drugs) of input target (SRC): Proto-oncogene tyrosine-protein kinase Src
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 57.9%
2 Approved SmallMoleculeDrug DB06589 Pazopanib Thumb 48.3%
3 Approved;
Nutraceutical		 SmallMoleculeDrug DB01373 Calcium Thumb 36.5%
4 Approved;
Investigational		 SmallMoleculeDrug DB00242 Cladribine Thumb 35.7%
5 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb 35.6%
6 Approved;
Nutraceutical		 SmallMoleculeDrug DB00157 NADH Thumb 35.5%
7 Experimental SmallMoleculeDrug DB04522 Dexfosfoserine Thumb 34.3%
8 Investigational SmallMoleculeDrug DB05913 OSI-930 Thumb 34.1%
9 Experimental SmallMoleculeDrug DB02467 L-methionine (S)-S-oxide Thumb 33.3%
10 Approved;
Investigational		 SmallMoleculeDrug DB08889 Carfilzomib Thumb 32.4%
11 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00118 Ademetionine Thumb 32.0%
12 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 31.9%
13 Experimental SmallMoleculeDrug DB08515 (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Thumb 31.8%
14 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb 29.9%
15 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 29.3%
16 Approved;
Investigational		 SmallMoleculeDrug DB06595 Midostaurin Thumb 29.3%
17 Approved SmallMoleculeDrug DB00419 Miglustat Thumb 29.1%
18 Approved;
Investigational		 SmallMoleculeDrug DB01268 Sunitinib Thumb 28.7%
19 Experimental SmallMoleculeDrug DB03120 Para-Toluene Sulfonate Thumb 28.7%
20 Experimental SmallMoleculeDrug DB07664 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE Thumb 28.6%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.