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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q7Z2W7
No. Gene UniProt ID Protein Name Pathway PDB
1 TRPM8 Q7Z2W7 Transient receptor potential cation channel subfamily M member 8 hsa04750 NA


7 known interactions (drugs) of input target (TRPM8): Transient receptor potential cation channel subfamily M member 8
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb
2 Approved SmallMoleculeDrug DB00825 Menthol Thumb
3 Approved SmallMoleculeDrug DB01744 Camphor Thumb
4 Experimental SmallMoleculeDrug DB11345 (S)-camphor Thumb
5 Investigational SmallMoleculeDrug DB11755 Tetrahydrocannabivarin Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb


20 predicted interactions (drugs) of input target (TRPM8): Transient receptor potential cation channel subfamily M member 8
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Investigational SmallMoleculeDrug DB14050 Cannabidivarin Thumb 47.4%
2 Experimental SmallMoleculeDrug DB02955 Ricinoleic Acid Thumb 35.3%
3 Approved SmallMoleculeDrug DB09086 Eugenol Thumb 34.5%
4 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb 32.4%
5 Approved;
Experimental		 SmallMoleculeDrug DB13746 Bioallethrin Thumb 30.6%
6 Approved;
Investigational		 SmallMoleculeDrug DB09229 Aranidipine Thumb 29.3%
7 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 29.1%
8 Approved;
Investigational		 SmallMoleculeDrug DB09238 Manidipine Thumb 28.3%
9 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 28.3%
10 Approved;
Nutraceutical		 SmallMoleculeDrug DB00157 NADH Thumb 28.3%
11 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 28.0%
12 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb 28.0%
13 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 27.9%
14 Investigational;
Withdrawn		 SmallMoleculeDrug DB01388 Mibefradil Thumb 27.7%
15 Approved;
Investigational		 SmallMoleculeDrug DB06155 Rimonabant Thumb 27.5%
16 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 27.5%
17 Approved;
Investigational		 SmallMoleculeDrug DB09288 Propacetamol Thumb 27.0%
18 Approved;
Investigational		 SmallMoleculeDrug DB09236 Lacidipine Thumb 26.4%
19 Investigational SmallMoleculeDrug DB12695 Phenethyl Isothiocyanate Thumb 26.2%
20 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 25.7%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.