QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P19099
No. Gene UniProt ID Protein Name Pathway PDB
1 CYP11B2 P19099 Cytochrome P450 11B2, mitochondrial hsa00140; hsa01100; hsa04925 4DVQ; 4FDH; 4ZGX


1 known interactions (drugs) of input target (CYP11B2): Cytochrome P450 11B2, mitochondrial
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb


20 predicted interactions (drugs) of input target (CYP11B2): Cytochrome P450 11B2, mitochondrial
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb 37.4%
2 Approved;
Investigational		 SmallMoleculeDrug DB09231 Benidipine Thumb 30.2%
3 Approved;
Investigational		 SmallMoleculeDrug DB01023 Felodipine Thumb 30.1%
4 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb 29.9%
5 Approved;
Investigational		 SmallMoleculeDrug DB00393 Nimodipine Thumb 29.9%
6 Approved;
Experimental		 SmallMoleculeDrug DB13746 Bioallethrin Thumb 29.1%
7 Investigational;
Withdrawn		 SmallMoleculeDrug DB01388 Mibefradil Thumb 27.6%
8 Approved;
Investigational		 SmallMoleculeDrug DB09238 Manidipine Thumb 26.7%
9 Approved;
Investigational		 SmallMoleculeDrug DB06712 Nilvadipine Thumb 26.4%
10 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 26.1%
11 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb 26.0%
12 Approved;
Investigational		 SmallMoleculeDrug DB01054 Nitrendipine Thumb 25.5%
13 Approved;
Investigational		 SmallMoleculeDrug DB01126 Dutasteride Thumb 24.8%
14 Approved SmallMoleculeDrug DB00825 Menthol Thumb 24.6%
15 Approved;
Investigational		 SmallMoleculeDrug DB00270 Isradipine Thumb 24.4%
16 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 24.3%
17 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb 24.2%
18 Approved;
Investigational		 SmallMoleculeDrug DB09232 Cilnidipine Thumb 24.1%
19 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb 23.9%
20 Approved;
Withdrawn		 SmallMoleculeDrug DB01244 Bepridil Thumb 23.8%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.