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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P23415
No. Gene UniProt ID Protein Name Pathway PDB
1 GLRA1 P23415 Glycine receptor subunit alpha-1 hsa04080 1MOT; 1VRY; 2M6B; 2M6I; 4X5T


22 known interactions (drugs) of input target (GLRA1): Glycine receptor subunit alpha-1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB01956 Taurine Thumb
2 Approved;
Withdrawn		 SmallMoleculeDrug DB00431 Lindane Thumb
3 Approved;
Vet approved		 SmallMoleculeDrug DB01236 Sevoflurane Thumb
4 Approved SmallMoleculeDrug DB01189 Desflurane Thumb
5 Experimental SmallMoleculeDrug DB00466 Picrotoxin Thumb
6 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
7 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB03929 D-Serine Thumb
8 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb
9 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00228 Enflurane Thumb
10 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01028 Methoxyflurane Thumb
11 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb
12 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb
13 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb
14 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb
15 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb
16 Investigational SmallMoleculeDrug DB05885 Seletracetam Thumb
17 Approved;
Investigational		 SmallMoleculeDrug DB09130 Copper Thumb
18 Approved;
Investigational		 SmallMoleculeDrug DB11582 Thiocolchicoside Thumb
19 Investigational SmallMoleculeDrug DB05417 GW 468816 Thumb
20 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00145 Glycine Thumb
21 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01381 Ginkgo biloba Thumb
22 Approved;
Vet approved		 SmallMoleculeDrug DB00572 Atropine Thumb


20 predicted interactions (drugs) of input target (GLRA1): Glycine receptor subunit alpha-1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb 76.6%
2 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 70.8%
3 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00312 Pentobarbital Thumb 68.9%
4 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00602 Ivermectin Thumb 64.0%
5 Approved;
Illicit		 SmallMoleculeDrug DB00237 Butabarbital Thumb 63.2%
6 Approved SmallMoleculeDrug DB00273 Topiramate Thumb 62.4%
7 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 61.9%
8 Approved;
Vet approved		 SmallMoleculeDrug DB00418 Secobarbital Thumb 61.6%
9 Approved;
Illicit		 SmallMoleculeDrug DB00306 Talbutal Thumb 61.6%
10 Approved;
Vet approved		 SmallMoleculeDrug DB00794 Primidone Thumb 61.5%
11 Approved;
Illicit		 SmallMoleculeDrug DB00371 Meprobamate Thumb 59.6%
12 Approved;
Investigational		 SmallMoleculeDrug DB11901 Apalutamide Thumb 59.5%
13 Approved;
Investigational		 SmallMoleculeDrug DB00659 Acamprosate Thumb 59.3%
14 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00475 Chlordiazepoxide Thumb 58.8%
15 Approved SmallMoleculeDrug DB00292 Etomidate Thumb 58.5%
16 Approved;
Illicit		 SmallMoleculeDrug DB00241 Butalbital Thumb 58.3%
17 Approved;
Illicit		 SmallMoleculeDrug DB01589 Quazepam Thumb 58.2%
18 Withdrawn SmallMoleculeDrug DB00463 Metharbital Thumb 57.8%
19 Approved;
Vet approved		 SmallMoleculeDrug DB00599 Thiopental Thumb 57.6%
20 Approved;
Illicit		 SmallMoleculeDrug DB01068 Clonazepam Thumb 57.5%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.