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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Results:

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Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P00915

No.	Gene	UniProt ID	Protein Name	Pathway	PDB
1	CA1	P00915	Carbonic anhydrase 1	hsa00910	1AZM; 1BZM; 1CRM; 1CZM; 1HCB; 1HUG; 1HUH; 1J9W; 1JV0; 2CAB; 2FOY; 2FW4; 2IT4; 2NMX; 2NN1; 2NN7; 3LXE; 3W6H; 3W6I; 4WR7; 4WUP; 4WUQ

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter	Image
1	Approved	SmallMoleculeDrug	DB01194	Brinzolamide	CCN[C@H]1CN(CCCOC)S(=O)(=O)C2=C1C=C(S2)S(N)(=O)=O
2	Approved	SmallMoleculeDrug	DB00869	Dorzolamide	CCN[C@H]1C[C@H](C)S(=O)(=O)C2=C1C=C(S2)S(N)(=O)=O
3	Approved	SmallMoleculeDrug	DB00562	Benzthiazide	NS(=O)(=O)C1=C(Cl)C=C2NC(CSCC3=CC=CC=C3)=NS(=O)(=O)C2=C1
4	Experimental	SmallMoleculeDrug	DB08155	N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE	CC(=O)NCCC1=CC=C(C=C1)S(N)(=O)=O
5	Approved; Vet approved	SmallMoleculeDrug	DB01021	Trichlormethiazide	NS(=O)(=O)C1=C(Cl)C=C2NC(NS(=O)(=O)C2=C1)C(Cl)Cl
6	Approved; Investigational	SmallMoleculeDrug	DB01144	Diclofenamide	NS(=O)(=O)C1=CC(=C(Cl)C(Cl)=C1)S(N)(=O)=O
7	Approved	SmallMoleculeDrug	DB01119	Diazoxide	CC1=NS(=O)(=O)C2=C(N1)C=CC(Cl)=C2
8	Approved	SmallMoleculeDrug	DB09460	Sodium carbonate	[Na+].[Na+].[O-]C([O-])=O
9	Approved; Illicit; Withdrawn	SmallMoleculeDrug	DB01031	Ethinamate	NC(=O)OC1(CCCCC1)C#C
10	Withdrawn	SmallMoleculeDrug	DB00311	Ethoxzolamide	CCOC1=CC2=C(C=C1)N=C(S2)S(N)(=O)=O
11	Approved	SmallMoleculeDrug	DB00436	Bendroflumethiazide	NS(=O)(=O)C1=CC2=C(NC(CC3=CC=CC=C3)NS2(=O)=O)C=C1C(F)(F)F
12	Experimental	SmallMoleculeDrug	DB08157	ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE	CCOC(=O)CCC1=CC=C(C=C1)S(N)(=O)=O
13	Approved	SmallMoleculeDrug	DB00232	Methyclothiazide	CN1C(CCl)NC2=CC(Cl)=C(C=C2S1(=O)=O)S(N)(=O)=O
14	Approved; Vet approved	SmallMoleculeDrug	DB00999	Hydrochlorothiazide	NS(=O)(=O)C1=C(Cl)C=C2NCNS(=O)(=O)C2=C1
15	Approved; Vet approved	SmallMoleculeDrug	DB09472	Sodium sulfate	[Na+].[Na+].[O-]S([O-])(=O)=O
16	Approved	SmallMoleculeDrug	DB01325	Quinethazone	CCC1NC(=O)C2=CC(=C(Cl)C=C2N1)S(N)(=O)=O
17	Approved	SmallMoleculeDrug	DB00606	Cyclothiazide	NS(=O)(=O)C1=C(Cl)C=C2NC(NS(=O)(=O)C2=C1)C1CC2CC1C=C2
18	Approved; Vet approved	SmallMoleculeDrug	DB00819	Acetazolamide	CC(=O)NC1=NN=C(S1)S(N)(=O)=O
19	Approved; Vet approved	SmallMoleculeDrug	DB00880	Chlorothiazide	NS(=O)(=O)C1=C(Cl)C=C2NC=NS(=O)(=O)C2=C1
20	Approved	SmallMoleculeDrug	DB00703	Methazolamide	CN1N=C(SC1=NC(C)=O)S(N)(=O)=O
21	Approved	SmallMoleculeDrug	DB00381	Amlodipine	CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC
22	Approved; Investigational	SmallMoleculeDrug	DB00909	Zonisamide	NS(=O)(=O)CC1=NOC2=CC=CC=C12
23	Approved; Vet approved	SmallMoleculeDrug	DB00423	Methocarbamol	COC1=CC=CC=C1OCC(O)COC(N)=O
24	Experimental	SmallMoleculeDrug	DB08156	3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID	NS(=O)(=O)C1=CC=C(CCC(O)=O)C=C1
25	Approved; Investigational	SmallMoleculeDrug	DB00774	Hydroflumethiazide	NS(=O)(=O)C1=CC2=C(NCNS2(=O)=O)C=C1C(F)(F)F
26	Investigational	SmallMoleculeDrug	DB08846	Ellagic Acid	OC1=C(O)C2=C3C(=C1)C(=O)OC1=C3C(=CC(O)=C1O)C(=O)O2
27	Approved	SmallMoleculeDrug	DB00273	Topiramate	[H][C@@]12CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@@]3([H])[C@]1([H])OC(C)(C)O2

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter	Image	Confidence score
1	Approved; Investigational	SmallMoleculeDrug	DB00391	Sulpiride	CCN1CCCC1CNC(=O)C1=C(OC)C=CC(=C1)S(N)(=O)=O		50.7%
2	Approved; Investigational; Withdrawn	SmallMoleculeDrug	DB00580	Valdecoxib	CC1=C(C(=NO1)C1=CC=CC=C1)C1=CC=C(C=C1)S(N)(=O)=O		50.3%
3	Approved; Investigational	SmallMoleculeDrug	DB00482	Celecoxib	CC1=CC=C(C=C1)C1=CC(=NN1C1=CC=C(C=C1)S(N)(=O)=O)C(F)(F)F		49.9%
4	Experimental	SmallMoleculeDrug	DB03385	4-Methylimidazole	CC1=CN=CN1		47.4%
5	Experimental	SmallMoleculeDrug	DB04203	3-Mercuri-4-Aminobenzenesulfonamide	NC1=CC=C(C=C1[Hg])S(N)(=O)=O		43.0%
6	Approved; Investigational	SmallMoleculeDrug	DB03904	Urea	NC(N)=O		42.3%
7	Experimental	SmallMoleculeDrug	DB07742	N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE	NS(=O)(=O)C1=CC=C(C=C1)C(=O)NCC1=CC=CC(F)=C1F		41.0%
8	Approved; Vet approved	SmallMoleculeDrug	DB00695	Furosemide	NS(=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C(O)=O		40.8%
9	Experimental	SmallMoleculeDrug	DB04002	4-Sulfonamide-[4-(Thiomethylaminobutane)]Benzamide	NS(=O)(=O)C1=CC=C(C=C1)C(=O)NCCCCNCS		40.7%
10	Experimental	SmallMoleculeDrug	DB02429	4-(Aminosulfonyl)-N-[(4-Fluorophenyl)Methyl]-Benzamide	NS(=O)(=O)C1=CC=C(C=C1)C(=O)NCC1=CC=C(F)C=C1		39.9%
11	Experimental	SmallMoleculeDrug	DB04549	4-(Aminosulfonyl)-N-[(2,3,4-Trifluorophenyl)Methyl]-Benzamide	NS(=O)(=O)C1=CC=C(C=C1)C(=O)NCC1=C(F)C(F)=C(F)C=C1		39.5%
12	Experimental	SmallMoleculeDrug	DB08765	6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE	NS(=O)(=O)C1=NC2=C(S1)C=C(O)C=C2		39.3%
13	Experimental	SmallMoleculeDrug	DB08046	2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide	NS(=O)(=O)C1=CC(=CC=C1Cl)[C@@]1(O)NC(=O)C2=CC=CC=C12		38.3%
14	Experimental	SmallMoleculeDrug	DB06954	2-(cycloheptylmethyl)-1,1-dioxido-1-benzothiophen-6-yl sulfamate	NS(=O)(=O)OC1=CC=C2C=C(CC3CCCCCC3)S(=O)(=O)C2=C1		38.3%
15	Experimental	SmallMoleculeDrug	DB03596	N-[2-(1h-Indol-5-Yl)-Butyl]-4-Sulfamoyl-Benzamide	[H][C@@](CC)(CNC(=O)C1=CC=C(C=C1)S(N)(=O)=O)C1=CC2=C(NC=C2)C=C1		38.3%
16	Approved; Experimental; Investigational	SmallMoleculeDrug	DB01942	Formic Acid	OC=O		38.3%
17	Experimental	SmallMoleculeDrug	DB04601	4-[(4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLE	NS(=O)(=O)OC1=CC=C(CN(N2C=NN=C2)C2=CC=C(C=C2)C#N)C=C1		38.2%
18	Approved	SmallMoleculeDrug	DB00524	Metolazone	CC1NC2=CC(Cl)=C(C=C2C(=O)N1C1=CC=CC=C1C)S(N)(=O)=O		37.8%
19	Experimental	SmallMoleculeDrug	DB02479	(R)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide	[H]N([H])S(=O)(=O)C1=CC=C(C=C1)C(=O)N([H])C[C@@H](C)CN1C=CC2=CC=CC=C12		37.7%
20	Experimental	SmallMoleculeDrug	DB04371	AL6528	COC1=CC(=CC=C1)N1C=CC2=C(SC(=C2)S(N)(=O)=O)S1(=O)=O		37.6%