QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: O00180
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNK1 O00180 Potassium channel subfamily K member 1 NA 3UKM


3 known interactions (drugs) of input target (KCNK1): Potassium channel subfamily K member 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB00908 Quinidine Thumb
2 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb
3 Approved SmallMoleculeDrug DB01346 Quinidine barbiturate Thumb


20 predicted interactions (drugs) of input target (KCNK1): Potassium channel subfamily K member 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 39.8%
2 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 33.4%
3 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 32.4%
4 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb 28.8%
5 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00653 Magnesium sulfate Thumb 28.2%
6 Approved SmallMoleculeDrug DB00590 Doxazosin Thumb 27.6%
7 Approved SmallMoleculeDrug DB00457 Prazosin Thumb 27.1%
8 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 26.9%
9 Approved;
Investigational		 SmallMoleculeDrug DB11633 Isavuconazole Thumb 26.8%
10 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01110 Miconazole Thumb 26.4%
11 Approved;
Withdrawn		 SmallMoleculeDrug DB01195 Flecainide Thumb 25.9%
12 Approved SmallMoleculeDrug DB01162 Terazosin Thumb 25.5%
13 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb 24.6%
14 Approved SmallMoleculeDrug DB00292 Etomidate Thumb 24.2%
15 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 23.6%
16 Approved;
Investigational		 SmallMoleculeDrug DB09232 Cilnidipine Thumb 23.5%
17 Approved;
Withdrawn		 SmallMoleculeDrug DB01244 Bepridil Thumb 23.4%
18 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00228 Enflurane Thumb 23.2%
19 Approved;
Investigational		 SmallMoleculeDrug DB00231 Temazepam Thumb 22.5%
20 Withdrawn SmallMoleculeDrug DB00463 Metharbital Thumb 22.3%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.