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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P28472
No. Gene UniProt ID Protein Name Pathway PDB
1 GABRB3 P28472 Gamma-aminobutyric acid receptor subunit beta-3 hsa04080; hsa04723; hsa04726; hsa04727; hsa05032; hsa05033 4COF


60 known interactions (drugs) of input target (GABRB3): Gamma-aminobutyric acid receptor subunit beta-3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00818 Propofol Thumb
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB01956 Taurine Thumb
3 Approved SmallMoleculeDrug DB00546 Adinazolam Thumb
4 Approved;
Withdrawn		 SmallMoleculeDrug DB00431 Lindane Thumb
5 Approved;
Illicit		 SmallMoleculeDrug DB01588 Prazepam Thumb
6 Investigational SmallMoleculeDrug DB12458 Muscimol Thumb
7 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00404 Alprazolam Thumb
8 Withdrawn SmallMoleculeDrug DB00463 Metharbital Thumb
9 Approved;
Vet approved		 SmallMoleculeDrug DB00592 Piperazine Thumb
10 Approved;
Investigational		 SmallMoleculeDrug DB11901 Apalutamide Thumb
11 Approved;
Illicit		 SmallMoleculeDrug DB01567 Fludiazepam Thumb
12 Approved SmallMoleculeDrug DB01189 Desflurane Thumb
13 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00312 Pentobarbital Thumb
14 Approved;
Illicit		 SmallMoleculeDrug DB01215 Estazolam Thumb
15 Approved SmallMoleculeDrug DB00425 Zolpidem Thumb
16 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
17 Approved;
Illicit		 SmallMoleculeDrug DB01589 Quazepam Thumb
18 Approved;
Illicit		 SmallMoleculeDrug DB00237 Butabarbital Thumb
19 Approved SmallMoleculeDrug DB01594 Cinolazepam Thumb
20 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01028 Methoxyflurane Thumb
21 Approved;
Illicit		 SmallMoleculeDrug DB01559 Clotiazepam Thumb
22 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00228 Enflurane Thumb
23 Approved;
Illicit		 SmallMoleculeDrug DB00349 Clobazam Thumb
24 Approved;
Illicit		 SmallMoleculeDrug DB00683 Midazolam Thumb
25 Approved;
Illicit		 SmallMoleculeDrug DB00241 Butalbital Thumb
26 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00475 Chlordiazepoxide Thumb
27 Approved;
Vet approved		 SmallMoleculeDrug DB00794 Primidone Thumb
28 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb
29 Approved;
Illicit;
Withdrawn		 SmallMoleculeDrug DB00801 Halazepam Thumb
30 Approved SmallMoleculeDrug DB00842 Oxazepam Thumb
31 Approved;
Investigational		 SmallMoleculeDrug DB00897 Triazolam Thumb
32 Approved;
Investigational		 SmallMoleculeDrug DB00659 Acamprosate Thumb
33 Approved;
Illicit		 SmallMoleculeDrug DB00628 Clorazepate Thumb
34 Approved;
Illicit;
Investigational;
Vet approved		 SmallMoleculeDrug DB00829 Diazepam Thumb
35 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb
36 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB01558 Bromazepam Thumb
37 Approved;
Illicit		 SmallMoleculeDrug DB01544 Flunitrazepam Thumb
38 Approved;
Investigational		 SmallMoleculeDrug DB00402 Eszopiclone Thumb
39 Approved SmallMoleculeDrug DB00186 Lorazepam Thumb
40 Approved SmallMoleculeDrug DB09118 Stiripentol Thumb
41 Approved;
Vet approved		 SmallMoleculeDrug DB01236 Sevoflurane Thumb
42 Approved SmallMoleculeDrug DB00273 Topiramate Thumb
43 Approved SmallMoleculeDrug DB00292 Etomidate Thumb
44 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb
45 Approved;
Illicit;
Withdrawn		 SmallMoleculeDrug DB00189 Ethchlorvynol Thumb
46 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB06716 Fospropofol Thumb
47 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb
48 Approved;
Investigational		 SmallMoleculeDrug DB00231 Temazepam Thumb
49 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00690 Flurazepam Thumb
50 Approved;
Investigational		 SmallMoleculeDrug DB11582 Thiocolchicoside Thumb
51 Approved;
Illicit		 SmallMoleculeDrug DB01068 Clonazepam Thumb
52 Approved;
Illicit		 SmallMoleculeDrug DB01437 Glutethimide Thumb
53 Approved;
Illicit		 SmallMoleculeDrug DB00371 Meprobamate Thumb
54 Approved SmallMoleculeDrug DB01595 Nitrazepam Thumb
55 Approved SmallMoleculeDrug DB01205 Flumazenil Thumb
56 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
57 Approved;
Illicit;
Withdrawn		 SmallMoleculeDrug DB01107 Methyprylon Thumb
58 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
59 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00602 Ivermectin Thumb
60 Approved;
Illicit		 SmallMoleculeDrug DB00306 Talbutal Thumb


20 predicted interactions (drugs) of input target (GABRB3): Gamma-aminobutyric acid receptor subunit beta-3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Investigational SmallMoleculeDrug DB06579 Adipiplon Thumb 92.5%
2 Experimental SmallMoleculeDrug DB13983 5,7,2′-trihydroxy-6,8-dimethoxyflavone Thumb 90.4%
3 Approved SmallMoleculeDrug DB01587 Ketazolam Thumb 89.6%
4 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01381 Ginkgo biloba Thumb 87.2%
5 Approved SmallMoleculeDrug DB09166 Etizolam Thumb 84.3%
6 Approved SmallMoleculeDrug DB13872 Lormetazepam Thumb 84.1%
7 Approved SmallMoleculeDrug DB00849 Methylphenobarbital Thumb 81.8%
8 Approved SmallMoleculeDrug DB00395 Carisoprodol Thumb 81.1%
9 Approved SmallMoleculeDrug DB01355 Hexobarbital Thumb 80.7%
10 Approved;
Vet approved		 SmallMoleculeDrug DB00599 Thiopental Thumb 80.0%
11 Approved;
Vet approved		 SmallMoleculeDrug DB00418 Secobarbital Thumb 79.6%
12 Illicit SmallMoleculeDrug DB01483 Barbital Thumb 78.8%
13 Approved SmallMoleculeDrug DB01198 Zopiclone Thumb 78.1%
14 Investigational SmallMoleculeDrug DB05087 Ganaxolone Thumb 77.9%
15 Experimental;
Illicit		 SmallMoleculeDrug DB01496 Barbituric acid derivative Thumb 76.1%
16 Approved;
Illicit		 SmallMoleculeDrug DB01353 Butethal Thumb 75.8%
17 Approved;
Illicit		 SmallMoleculeDrug DB01352 Aprobarbital Thumb 75.3%
18 Approved;
Illicit		 SmallMoleculeDrug DB01351 Amobarbital Thumb 75.0%
19 Experimental SmallMoleculeDrug DB00466 Picrotoxin Thumb 74.8%
20 Approved SmallMoleculeDrug DB01354 Heptabarbital Thumb 73.8%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.