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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P35498
No. Gene UniProt ID Protein Name Pathway PDB
1 SCN1A P35498 Sodium channel protein type 1 subunit alpha hsa04728 NA


12 known interactions (drugs) of input target (SCN1A): Sodium channel protein type 1 subunit alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB13269 Dichlorobenzyl alcohol Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB00909 Zonisamide Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB04930 Permethrin Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB00313 Valproic Acid Thumb
5 Investigational SmallMoleculeDrug DB05232 Tetrodotoxin Thumb
6 Approved SmallMoleculeDrug DB01438 Phenazopyridine Thumb
7 Approved SmallMoleculeDrug DB01595 Nitrazepam Thumb
8 Approved;
Vet approved		 SmallMoleculeDrug DB00252 Phenytoin Thumb
9 Approved SmallMoleculeDrug DB00273 Topiramate Thumb
10 Approved;
Investigational		 SmallMoleculeDrug DB05541 Brivaracetam Thumb
11 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb
12 Approved SmallMoleculeDrug DB01121 Phenacemide Thumb


20 predicted interactions (drugs) of input target (SCN1A): Sodium channel protein type 1 subunit alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 59.3%
2 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00818 Propofol Thumb 53.5%
3 Approved SmallMoleculeDrug DB01594 Cinolazepam Thumb 46.3%
4 Approved;
Withdrawn		 SmallMoleculeDrug DB00431 Lindane Thumb 44.8%
5 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00312 Pentobarbital Thumb 44.1%
6 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 43.4%
7 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb 43.3%
8 Approved SmallMoleculeDrug DB06218 Lacosamide Thumb 42.6%
9 Approved SmallMoleculeDrug DB00292 Etomidate Thumb 42.3%
10 Approved;
Illicit;
Investigational;
Vet approved		 SmallMoleculeDrug DB00829 Diazepam Thumb 41.8%
11 Approved;
Illicit		 SmallMoleculeDrug DB01559 Clotiazepam Thumb 41.1%
12 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb 41.1%
13 Approved;
Illicit		 SmallMoleculeDrug DB00907 Cocaine Thumb 41.0%
14 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb 40.9%
15 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 40.7%
16 Approved;
Investigational		 SmallMoleculeDrug DB00897 Triazolam Thumb 40.6%
17 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01381 Ginkgo biloba Thumb 40.2%
18 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB01558 Bromazepam Thumb 40.0%
19 Approved;
Illicit		 SmallMoleculeDrug DB01215 Estazolam Thumb 39.0%
20 Approved;
Illicit		 SmallMoleculeDrug DB00683 Midazolam Thumb 38.5%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.