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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P19793
No. Gene UniProt ID Protein Name Pathway PDB
1 RXRA P19793 Retinoic acid receptor RXR-alpha hsa03320; hsa04151; hsa04659; hsa04919; hsa04920; hsa04928; hsa04932; hsa04976; hsa05160; hsa05200; hsa05202; hsa05216; hsa05222; hsa05223; hsa05226


21 known interactions (drugs) of input target (RXRA): Retinoic acid receptor RXR-alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB08402 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID Thumb
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB00132 Alpha-Linolenic Acid Thumb
3 Experimental SmallMoleculeDrug DB08063 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE Thumb
4 Approved;
Nutraceutical		 SmallMoleculeDrug DB01436 Alfacalcidol Thumb
5 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB04224 Oleic Acid Thumb
6 Withdrawn SmallMoleculeDrug DB00926 Etretinate Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB00412 Rosiglitazone Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB00523 Alitretinoin Thumb
9 Experimental SmallMoleculeDrug DB08601 tributylstannanyl Thumb
10 Investigational SmallMoleculeDrug DB05956 EVT-101 Thumb
11 Experimental SmallMoleculeDrug DB07863 2-chloro-5-nitro-N-phenylbenzamide Thumb
12 Approved;
Investigational		 SmallMoleculeDrug DB01393 Bezafibrate Thumb
13 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00755 Tretinoin Thumb
14 Experimental SmallMoleculeDrug DB07557 (5BETA)-PREGNANE-3,20-DIONE Thumb
15 Experimental SmallMoleculeDrug DB04557 Arachidonic Acid Thumb
16 Approved SmallMoleculeDrug DB00210 Adapalene Thumb
17 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00749 Etodolac Thumb
18 Approved;
Investigational		 SmallMoleculeDrug DB03756 Doconexent Thumb
19 Experimental SmallMoleculeDrug DB02746 Phthalic Acid Thumb
20 Approved;
Investigational		 SmallMoleculeDrug DB00307 Bexarotene Thumb
21 Approved SmallMoleculeDrug DB00459 Acitretin Thumb


20 predicted interactions (drugs) of input target (RXRA): Retinoic acid receptor RXR-alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb 41.6%
2 Approved;
Investigational		 SmallMoleculeDrug DB00799 Tazarotene Thumb 40.3%
3 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb 39.3%
4 Experimental SmallMoleculeDrug DB07080 N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE Thumb 38.8%
5 Experimental SmallMoleculeDrug DB02266 Flufenamic Acid Thumb 38.5%
6 Approved;
Investigational		 SmallMoleculeDrug DB00313 Valproic Acid Thumb 37.8%
7 Investigational SmallMoleculeDrug DB05785 LGD-1550 Thumb 35.9%
8 Approved;
Investigational		 SmallMoleculeDrug DB04942 Tamibarotene Thumb 33.6%
9 Experimental SmallMoleculeDrug DB08175 (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID Thumb 33.4%
10 Approved;
Nutraceutical		 SmallMoleculeDrug DB00159 Icosapent Thumb 32.7%
11 Approved SmallMoleculeDrug DB00573 Fenoprofen Thumb 30.9%
12 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb 30.8%
13 Approved SmallMoleculeDrug DB00982 Isotretinoin Thumb 29.2%
14 Experimental SmallMoleculeDrug DB07929 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE Thumb 28.8%
15 Investigational SmallMoleculeDrug DB05416 GW-501516 Thumb 28.6%
16 Experimental SmallMoleculeDrug DB08742 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) Thumb 28.5%
17 Approved SmallMoleculeDrug DB11605 Myrrh Thumb 28.4%
18 Experimental SmallMoleculeDrug DB07215 2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID Thumb 28.4%
19 Approved SmallMoleculeDrug DB01050 Ibuprofen Thumb 28.2%
20 Approved SmallMoleculeDrug DB09006 Clinofibrate Thumb 27.8%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.