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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P08581
No. Gene UniProt ID Protein Name Pathway PDB
1 MET P08581 Hepatocyte growth factor receptor hsa01521; hsa04010; hsa04014; hsa04015; hsa04151; hsa04360; hsa04510; hsa04520; hsa05100; hsa05120; hsa05144; hsa05200; hsa05202; hsa05205; hsa05206; hsa05211; hsa05218; hsa05225; hsa05226; hsa05230

14 known interactions (drugs) of input target (MET): Hepatocyte growth factor receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB02152 K-252a Thumb
2 Experimental SmallMoleculeDrug DB06995 N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide Thumb
3 Experimental SmallMoleculeDrug DB08791 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE Thumb
4 Experimental SmallMoleculeDrug DB08584 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline Thumb
5 Investigational SmallMoleculeDrug DB12742 Amuvatinib Thumb
6 Experimental SmallMoleculeDrug DB06896 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide Thumb
7 Approved SmallMoleculeDrug DB08865 Crizotinib Thumb
8 Experimental SmallMoleculeDrug DB06997 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide Thumb
9 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
10 Investigational SmallMoleculeDrug DB12200 Tivantinib Thumb
11 Experimental SmallMoleculeDrug DB07369 N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide Thumb
12 Experimental SmallMoleculeDrug DB07969 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol Thumb
13 Approved;
SmallMoleculeDrug DB08875 Cabozantinib Thumb
14 Approved;
SmallMoleculeDrug DB12267 Brigatinib Thumb

20 predicted interactions (drugs) of input target (MET): Hepatocyte growth factor receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB03147 Flavin adenine dinucleotide Thumb 44.6%
2 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 30.4%
3 Approved SmallMoleculeDrug DB01045 Rifampicin Thumb 28.1%
4 Approved;
SmallMoleculeDrug DB14011 Nabiximols Thumb 28.1%
5 Investigational;
SmallMoleculeDrug DB00171 ATP Thumb 28.0%
6 Approved SmallMoleculeDrug DB08916 Afatinib Thumb 27.8%
7 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 26.9%
8 Approved SmallMoleculeDrug DB00825 Menthol Thumb 26.8%
9 Approved;
SmallMoleculeDrug DB00182 Amphetamine Thumb 26.2%
10 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb 26.1%
11 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb 26.0%
12 Experimental SmallMoleculeDrug DB01863 Inositol 1,3,4,5-Tetrakisphosphate Thumb 25.8%
13 Experimental SmallMoleculeDrug DB04522 Dexfosfoserine Thumb 25.5%
14 Approved;
SmallMoleculeDrug DB01373 Calcium Thumb 25.4%
15 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 25.1%
16 Investigational SmallMoleculeDrug DB06021 AV-412 Thumb 24.2%
17 Approved;
SmallMoleculeDrug DB09061 Cannabidiol Thumb 23.9%
18 Approved;
SmallMoleculeDrug DB00142 Glutamic Acid Thumb 23.7%
19 Approved;
SmallMoleculeDrug DB01126 Dutasteride Thumb 23.5%
20 Approved;
SmallMoleculeDrug DB00398 Sorafenib Thumb 23.4%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.