QuartataWeb 1.0

25 known interactions (drugs) of input target (PPARD): Peroxisome proliferator-activated receptor delta

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter
1	Approved	SmallMoleculeDrug	DB01039	Fenofibrate	CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C1=CC=C(Cl)C=C1
2	Experimental	SmallMoleculeDrug	DB07070	(2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid	[H][C@](CC)(CC1=CC(CNC(=O)C2=C(F)C=C(C=C2)C(F)(F)F)=C(OC)C=C1)C(O)=O
3	Experimental	SmallMoleculeDrug	DB08078	{4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid	CCCC1=C(OCCCOC2=CC=C(OCC(O)=O)C=C2)C=CC(C(C)=O)=C1O
4	Approved; Investigational	SmallMoleculeDrug	DB00605	Sulindac	CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(C=C1)S(C)=O
5	Experimental	SmallMoleculeDrug	DB07691	2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid	OC(=O)C1=C(NC(=O)C2=CC=CC(=C2)S(=O)(=O)N2CCC3=CC=CC=C3C2)C=CC=C1
6	Experimental	SmallMoleculeDrug	DB04801	(11E)-OCTADEC-11-ENOIC ACID	CCCCCC\C=C/CCCCCCCCCC(O)=O
7	Investigational	SmallMoleculeDrug	DB05416	GW-501516	CC1=C(CSC2=CC(C)=C(OCC(O)=O)C=C2)SC(=N1)C1=CC=C(C=C1)C(F)(F)F
8	Experimental	SmallMoleculeDrug	DB07724	Indeglitazar	COC1=CC=C(C=C1)S(=O)(=O)N1C=C(CCC(O)=O)C2=CC(OC)=CC=C12
9	Approved; Nutraceutical	SmallMoleculeDrug	DB13961	Fish oil	NA
10	Approved; Investigational	SmallMoleculeDrug	DB00412	Rosiglitazone	CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C1=CC=CC=N1
11	Experimental	SmallMoleculeDrug	DB02746	Phthalic Acid	OC(=O)C1=CC=CC=C1C(O)=O
12	Investigational	SmallMoleculeDrug	DB05188	KD3010	NA
13	Approved; Investigational	SmallMoleculeDrug	DB01393	Bezafibrate	CC(C)(OC1=CC=C(CCNC(=O)C2=CC=C(Cl)C=C2)C=C1)C(O)=O
14	Approved; Nutraceutical	SmallMoleculeDrug	DB00132	Alpha-Linolenic Acid	CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O
15	Investigational; Withdrawn	SmallMoleculeDrug	DB00197	Troglitazone	CC1=C(C)C2=C(CCC(C)(COC3=CC=C(CC4SC(=O)NC4=O)C=C3)O2)C(C)=C1O
16	Approved; Nutraceutical	SmallMoleculeDrug	DB00159	Icosapent	CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
17	Investigational	SmallMoleculeDrug	DB05187	Elafibranor	CSC1=CC=C(C=C1)C(=O)\C=C\C1=CC(C)=C(OC(C)(C)C(O)=O)C(C)=C1
18	Approved; Investigational	SmallMoleculeDrug	DB00374	Treprostinil	[H][C@]12C[C@@H](O)[C@H](CC[C@@H](O)CCCCC)[C@@]1([H])CC1=C(C2)C(OCC(O)=O)=CC=C1
19	Approved	SmallMoleculeDrug	DB09006	Clinofibrate	CCC(C)(OC1=CC=C(C=C1)C1(CCCCC1)C1=CC=C(OC(C)(CC)C(O)=O)C=C1)C(O)=O
20	Approved	SmallMoleculeDrug	DB13873	Fenofibric acid	CC(C)(OC1=CC=C(C=C1)C(=O)C1=CC=C(Cl)C=C1)C(O)=O
21	Experimental	SmallMoleculeDrug	DB03338	Heptyl-Beta-D-Glucopyranoside	[H][C@]1(O)[C@]([H])(O)[C@@]([H])(CO)O[C@@]([H])(OCCCCCCC)[C@]1([H])O
22	Approved; Investigational	SmallMoleculeDrug	DB00313	Valproic Acid	CCCC(CCC)C(O)=O
23	Approved; Investigational	SmallMoleculeDrug	DB01132	Pioglitazone	CCC1=CN=C(CCOC2=CC=C(CC3SC(=O)NC3=O)C=C2)C=C1
24	Approved; Investigational; Vet approved	SmallMoleculeDrug	DB04224	Oleic Acid	CCCCCCCC\C=C\CCCCCCCC(O)=O
25	Approved; Investigational	SmallMoleculeDrug	DB09462	Glycerin	OCC(O)CO

20 predicted interactions (drugs) of input target (PPARD): Peroxisome proliferator-activated receptor delta

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter	Confidence score
1	Experimental	SmallMoleculeDrug	DB02266	Flufenamic Acid	OC(=O)C1=CC=CC=C1NC1=CC(=CC=C1)C(F)(F)F	51.9%
2	Approved; Investigational	SmallMoleculeDrug	DB03756	Doconexent	CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O	51.5%
3	Experimental	SmallMoleculeDrug	DB04557	Arachidonic Acid	CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O	50.6%
4	Approved	SmallMoleculeDrug	DB00573	Fenoprofen	CC(C(O)=O)C1=CC(OC2=CC=CC=C2)=CC=C1	50.0%
5	Approved; Investigational	SmallMoleculeDrug	DB00328	Indomethacin	COC1=CC2=C(C=C1)N(C(=O)C1=CC=C(Cl)C=C1)C(C)=C2CC(O)=O	49.8%
6	Investigational	SmallMoleculeDrug	DB04971	Reglixane	NA	48.5%
7	Investigational	SmallMoleculeDrug	DB06521	Ertiprotafib	CC1=C(C)C2=C(C3=CC(C)=C(O[C@H](CC4=CC=CC=C4)C(O)=O)C(C)=C3)C3=CC=CC=C3C(Br)=C2S1	45.9%
8	Investigational	SmallMoleculeDrug	DB06536	Tesaglitazar	CCO[C@@H](CC1=CC=C(OCCC2=CC=C(OS(C)(=O)=O)C=C2)C=C1)C(O)=O	45.8%
9	Investigational	SmallMoleculeDrug	DB08915	Aleglitazar	CO[C@@H](CC1=CC=C(OCCC2=C(C)OC(=N2)C2=CC=CC=C2)C2=C1SC=C2)C(O)=O	45.4%
10	Approved; Investigational	SmallMoleculeDrug	DB12007	Isoflavone	O=C1C(=COC2=CC=CC=C12)C1=CC=CC=C1	45.3%
11	Approved; Experimental	SmallMoleculeDrug	DB03796	Palmitic Acid	CCCCCCCCCCCCCCCC(O)=O	44.3%
12	Approved; Nutraceutical	SmallMoleculeDrug	DB11133	Omega-3 fatty acids	NA	42.1%
13	Investigational	SmallMoleculeDrug	DB06533	Ragaglitazar	CCO[C@H](CC1=CC=C(OCCN2C3=CC=CC=C3OC3=C2C=CC=C3)C=C1)C(O)=O	42.0%
14	Investigational	SmallMoleculeDrug	DB06510	Muraglitazar	COC1=CC=C(OC(=O)N(CC(O)=O)CC2=CC=C(OCCC3=C(C)OC(=N3)C3=CC=CC=C3)C=C2)C=C1	41.5%
15	Experimental	SmallMoleculeDrug	DB08402	2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID	OC(=O)C1=C(NC(=O)C2=C(Cl)C=C(Cl)C=C2)C=CC(OC2=NC=CC=N2)=C1	41.5%
16	Experimental	SmallMoleculeDrug	DB07215	2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID	CC1=C(SC(=N1)C1=CC=C(C=C1)C(F)(F)F)C(=O)NCC1=CC=C(OC(C)(C)C(O)=O)C=C1	40.9%
17	Approved; Investigational	SmallMoleculeDrug	DB09064	Ciprofibrate	CC(C)(OC1=CC=C(C=C1)C1CC1(Cl)Cl)C(O)=O	40.3%
18	Approved; Investigational	SmallMoleculeDrug	DB08604	Triclosan	OC1=CC(Cl)=CC=C1OC1=C(Cl)C=C(Cl)C=C1	39.6%
19	Experimental	SmallMoleculeDrug	DB07209	(8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid	[H][C@@](O)(CC(=O)CCCCC(O)=O)\C=C/C\C=C/CCCCC	39.0%
20	Experimental	SmallMoleculeDrug	DB07302	(9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid	[H][C@](O)(CCCCCCCC(O)=O)\C=C\C=C/CCCCC	38.6%