QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P09917
No. Gene UniProt ID Protein Name Pathway PDB
1 ALOX5 P09917 Arachidonate 5-lipoxygenase hsa00590; hsa01100; hsa04664; hsa04726; hsa04913; hsa05145 2ABV; 3O8Y; 3V92; 3V98; 3V99


22 known interactions (drugs) of input target (ALOX5): Arachidonate 5-lipoxygenase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00795 Sulfasalazine Thumb
2 Nutraceutical SmallMoleculeDrug DB01892 Hyperforin Thumb
3 Approved SmallMoleculeDrug DB00233 Aminosalicylic Acid Thumb
4 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB14002 D-alpha-Tocopherol acetate Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB01017 Minocycline Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB01014 Balsalazide Thumb
7 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00163 Vitamin E Thumb
8 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB14001 alpha-Tocopherol succinate Thumb
9 Approved SmallMoleculeDrug DB00244 Mesalazine Thumb
10 Approved;
Vet approved		 SmallMoleculeDrug DB00939 Meclofenamic acid Thumb
11 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00744 Zileuton Thumb
12 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb
13 Approved SmallMoleculeDrug DB00471 Montelukast Thumb
14 Approved SmallMoleculeDrug DB09285 Morniflumate Thumb
15 Investigational SmallMoleculeDrug DB05431 MLN-977 Thumb
16 Approved;
Investigational		 SmallMoleculeDrug DB00179 Masoprocol Thumb
17 Approved;
Investigational		 SmallMoleculeDrug DB11994 Diacerein Thumb
18 Investigational SmallMoleculeDrug DB04725 Licofelone Thumb
19 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb
20 Approved;
Vet approved		 SmallMoleculeDrug DB00586 Diclofenac Thumb
21 Experimental SmallMoleculeDrug DB13174 Rhein Thumb
22 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00711 Diethylcarbamazine Thumb


20 predicted interactions (drugs) of input target (ALOX5): Arachidonate 5-lipoxygenase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Vet approved		 SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 42.2%
2 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb 40.6%
3 Approved;
Investigational		 SmallMoleculeDrug DB00605 Sulindac Thumb 37.5%
4 Experimental;
Investigational		 SmallMoleculeDrug DB04216 Quercetin Thumb 37.2%
5 Experimental SmallMoleculeDrug DB01812 Adenosine-3'-5'-Diphosphate Thumb 36.7%
6 Approved;
Investigational		 SmallMoleculeDrug DB09213 Dexibuprofen Thumb 34.6%
7 Approved;
Investigational		 SmallMoleculeDrug DB08895 Tofacitinib Thumb 34.4%
8 Approved SmallMoleculeDrug DB05294 Vandetanib Thumb 33.3%
9 Experimental SmallMoleculeDrug DB02266 Flufenamic Acid Thumb 32.2%
10 Approved;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB00821 Carprofen Thumb 32.0%
11 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb 30.8%
12 Approved;
Nutraceutical		 SmallMoleculeDrug DB00157 NADH Thumb 30.0%
13 Experimental SmallMoleculeDrug DB04557 Arachidonic Acid Thumb 28.8%
14 Experimental SmallMoleculeDrug DB07080 N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE Thumb 28.7%
15 Experimental SmallMoleculeDrug DB03866 Prostaglandin G2 Thumb 28.6%
16 Approved SmallMoleculeDrug DB08910 Pomalidomide Thumb 28.4%
17 Approved;
Nutraceutical		 SmallMoleculeDrug DB00132 Alpha-Linolenic Acid Thumb 28.2%
18 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00914 Phenformin Thumb 28.1%
19 Investigational SmallMoleculeDrug DB06486 Enzastaurin Thumb 28.1%
20 Approved SmallMoleculeDrug DB01050 Ibuprofen Thumb 27.6%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.