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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: O60488
No. Gene UniProt ID Protein Name Pathway PDB
1 ACSL4 O60488 Long-chain-fatty-acid--CoA ligase 4 hsa00061; hsa00071; hsa01100; hsa01212; hsa03320; hsa04146; hsa04216; hsa04714; hsa04920 NA

3 known interactions (drugs) of input target (ACSL4): Long-chain-fatty-acid--CoA ligase 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
SmallMoleculeDrug DB00159 Icosapent Thumb
2 Investigational;
SmallMoleculeDrug DB00197 Troglitazone Thumb
3 Approved;
SmallMoleculeDrug DB00412 Rosiglitazone Thumb

20 predicted interactions (drugs) of input target (ACSL4): Long-chain-fatty-acid--CoA ligase 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB00132 Alpha-Linolenic Acid Thumb 46.5%
2 Experimental SmallMoleculeDrug DB02746 Phthalic Acid Thumb 44.3%
3 Approved;
SmallMoleculeDrug DB01393 Bezafibrate Thumb 38.3%
4 Approved;
SmallMoleculeDrug DB13961 Fish oil Thumb 30.5%
5 Approved SmallMoleculeDrug DB01039 Fenofibrate Thumb 30.3%
6 Approved;
Vet approved
SmallMoleculeDrug DB04224 Oleic Acid Thumb 28.8%
7 Experimental SmallMoleculeDrug DB07724 Indeglitazar Thumb 28.4%
8 Investigational SmallMoleculeDrug DB05187 Elafibranor Thumb 27.4%
9 Approved;
SmallMoleculeDrug DB12007 Isoflavone Thumb 27.4%
10 Investigational SmallMoleculeDrug DB05416 GW-501516 Thumb 27.4%
11 Approved;
SmallMoleculeDrug DB03756 Doconexent Thumb 26.8%
12 Investigational SmallMoleculeDrug DB12961 Leukotriene B4 Thumb 26.8%
13 Experimental SmallMoleculeDrug DB02266 Flufenamic Acid Thumb 26.5%
14 Approved;
SmallMoleculeDrug DB02709 Resveratrol Thumb 26.3%
15 Approved;
SmallMoleculeDrug DB01132 Pioglitazone Thumb 26.2%
16 Investigational SmallMoleculeDrug DB05188 KD3010 Thumb 25.6%
17 Approved;
SmallMoleculeDrug DB00328 Indomethacin Thumb 24.7%
18 Experimental SmallMoleculeDrug DB04557 Arachidonic Acid Thumb 24.5%
19 Approved SmallMoleculeDrug DB00573 Fenoprofen Thumb 24.5%
20 Experimental SmallMoleculeDrug DB04801 (11E)-OCTADEC-11-ENOIC ACID Thumb 24.5%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.