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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P23219
No. Gene UniProt ID Protein Name Pathway PDB
1 PTGS1 P23219 Prostaglandin G/H synthase 1 hsa00590; hsa01100; hsa04611; hsa04726; hsa04923 NA


77 known interactions (drugs) of input target (PTGS1): Prostaglandin G/H synthase 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB01600 Tiaprofenic acid Thumb
2 Withdrawn SmallMoleculeDrug DB03783 Phenacetin Thumb
3 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00749 Etodolac Thumb
4 Approved SmallMoleculeDrug DB00795 Sulfasalazine Thumb
5 Approved;
Vet approved		 SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb
6 Approved SmallMoleculeDrug DB00784 Mefenamic acid Thumb
7 Approved;
Vet approved		 SmallMoleculeDrug DB00586 Diclofenac Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB09288 Propacetamol Thumb
9 Experimental SmallMoleculeDrug DB01837 O-acetyl-L-serine Thumb
10 Approved;
Vet approved		 SmallMoleculeDrug DB00814 Meloxicam Thumb
11 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00154 Dihomo-gamma-linolenic acid Thumb
12 Experimental SmallMoleculeDrug DB02110 Protoporphyrin Ix Containing Co Thumb
13 Nutraceutical SmallMoleculeDrug DB01892 Hyperforin Thumb
14 Experimental SmallMoleculeDrug DB07981 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1R)-1-(hydroxymethyl)propyl]acetamide Thumb
15 Experimental SmallMoleculeDrug DB04557 Arachidonic Acid Thumb
16 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB04817 Metamizole Thumb
17 Approved SmallMoleculeDrug DB00991 Oxaprozin Thumb
18 Approved SmallMoleculeDrug DB01401 Choline magnesium trisalicylate Thumb
19 Approved SmallMoleculeDrug DB01397 Magnesium salicylate Thumb
20 Approved;
Investigational		 SmallMoleculeDrug DB00328 Indomethacin Thumb
21 Experimental SmallMoleculeDrug DB07984 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1S)-1-(hydroxymethyl)propyl]acetamide Thumb
22 Experimental SmallMoleculeDrug DB02047 2-(1,1'-Biphenyl-4-Yl)Propanoic Acid Thumb
23 Approved;
Investigational		 SmallMoleculeDrug DB09213 Dexibuprofen Thumb
24 Approved SmallMoleculeDrug DB11079 Trolamine salicylate Thumb
25 Approved SmallMoleculeDrug DB11071 Phenyl salicylate Thumb
26 Approved;
Experimental		 SmallMoleculeDrug DB13346 Bufexamac Thumb
27 Approved SmallMoleculeDrug DB00469 Tenoxicam Thumb
28 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB13783 Acemetacin Thumb
29 Approved;
Investigational		 SmallMoleculeDrug DB01014 Balsalazide Thumb
30 Experimental SmallMoleculeDrug DB02266 Flufenamic Acid Thumb
31 Experimental SmallMoleculeDrug DB02773 (3-Chloro-4-Propoxy-Phenyl)-Acetic Acid Thumb
32 Experimental SmallMoleculeDrug DB02379 Beta-D-Glucose Thumb
33 Approved;
Investigational		 SmallMoleculeDrug DB09216 Tolfenamic Acid Thumb
34 Approved SmallMoleculeDrug DB00573 Fenoprofen Thumb
35 Approved;
Investigational		 SmallMoleculeDrug DB00350 Minoxidil Thumb
36 Approved;
Investigational		 SmallMoleculeDrug DB00605 Sulindac Thumb
37 Approved;
Vet approved		 SmallMoleculeDrug DB00788 Naproxen Thumb
38 Approved SmallMoleculeDrug DB00244 Mesalazine Thumb
39 Approved;
Vet approved		 SmallMoleculeDrug DB00939 Meclofenamic acid Thumb
40 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00936 Salicylic acid Thumb
41 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb
42 Experimental SmallMoleculeDrug DB07983 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID Thumb
43 Approved;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB00821 Carprofen Thumb
44 Approved;
Investigational		 SmallMoleculeDrug DB09212 Loxoprofen Thumb
45 Approved;
Investigational		 SmallMoleculeDrug DB06802 Nepafenac Thumb
46 Approved;
Investigational		 SmallMoleculeDrug DB01435 Antipyrine Thumb
47 Approved;
Nutraceutical		 SmallMoleculeDrug DB00159 Icosapent Thumb
48 Approved;
Investigational		 SmallMoleculeDrug DB08814 Triflusal Thumb
49 Approved;
Investigational		 SmallMoleculeDrug DB00554 Piroxicam Thumb
50 Approved SmallMoleculeDrug DB01050 Ibuprofen Thumb
51 Approved;
Investigational		 SmallMoleculeDrug DB00861 Diflunisal Thumb
52 Withdrawn SmallMoleculeDrug DB09215 Droxicam Thumb
53 Experimental SmallMoleculeDrug DB03753 Flurbiprofen Methyl Ester Thumb
54 Approved;
Investigational		 SmallMoleculeDrug DB06736 Aceclofenac Thumb
55 Approved SmallMoleculeDrug DB11201 Menthyl salicylate Thumb
56 Approved SmallMoleculeDrug DB00963 Bromfenac Thumb
57 Approved;
Investigational		 SmallMoleculeDrug DB00712 Flurbiprofen Thumb
58 Approved SmallMoleculeDrug DB11323 Glycol salicylate Thumb
59 Approved;
Investigational		 SmallMoleculeDrug DB06725 Lornoxicam Thumb
60 Experimental SmallMoleculeDrug DB03667 Acetic Acid Salicyloyl-Amino-Ester Thumb
61 Investigational SmallMoleculeDrug DB12445 Nitroaspirin Thumb
62 Approved;
Investigational		 SmallMoleculeDrug DB01283 Lumiracoxib Thumb
63 Approved SmallMoleculeDrug DB00461 Nabumetone Thumb
64 Approved;
Vet approved		 SmallMoleculeDrug DB01009 Ketoprofen Thumb
65 Approved SmallMoleculeDrug DB00500 Tolmetin Thumb
66 Approved SmallMoleculeDrug DB04552 Niflumic Acid Thumb
67 Approved SmallMoleculeDrug DB00465 Ketorolac Thumb
68 Experimental SmallMoleculeDrug DB02198 2-Bromoacetyl Group Thumb
69 Approved SmallMoleculeDrug DB01399 Salsalate Thumb
70 Approved SmallMoleculeDrug DB01419 Antrafenine Thumb
71 Approved SmallMoleculeDrug DB00316 Acetaminophen Thumb
72 Approved;
Investigational		 SmallMoleculeDrug DB09214 Dexketoprofen Thumb
73 Approved;
Withdrawn		 SmallMoleculeDrug DB00870 Suprofen Thumb
74 Approved SmallMoleculeDrug DB09295 Talniflumate Thumb
75 Approved;
Vet approved		 SmallMoleculeDrug DB00812 Phenylbutazone Thumb
76 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00711 Diethylcarbamazine Thumb
77 Experimental SmallMoleculeDrug DB03752 P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid Thumb


20 predicted interactions (drugs) of input target (PTGS1): Prostaglandin G/H synthase 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB09285 Morniflumate Thumb 71.9%
2 Investigational SmallMoleculeDrug DB05095 Cimicoxib Thumb 71.5%
3 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01404 Ginseng Thumb 71.1%
4 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00533 Rofecoxib Thumb 70.8%
5 Approved;
Investigational		 SmallMoleculeDrug DB01628 Etoricoxib Thumb 70.3%
6 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb 69.2%
7 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00580 Valdecoxib Thumb 68.6%
8 Approved SmallMoleculeDrug DB11327 Dipyrithione Thumb 67.1%
9 Approved SmallMoleculeDrug DB00210 Adapalene Thumb 66.7%
10 Experimental SmallMoleculeDrug DB03866 Prostaglandin G2 Thumb 66.1%
11 Approved;
Withdrawn		 SmallMoleculeDrug DB13167 Alclofenac Thumb 65.5%
12 Approved SmallMoleculeDrug DB08439 Parecoxib Thumb 65.5%
13 Experimental SmallMoleculeDrug DB03477 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole Thumb 65.4%
14 Approved SmallMoleculeDrug DB00233 Aminosalicylic Acid Thumb 65.3%
15 Investigational SmallMoleculeDrug DB04725 Licofelone Thumb 65.0%
16 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01041 Thalidomide Thumb 62.0%
17 Approved SmallMoleculeDrug DB00480 Lenalidomide Thumb 61.9%
18 Experimental;
Vet approved		 SmallMoleculeDrug DB09217 Firocoxib Thumb 61.8%
19 Approved SmallMoleculeDrug DB08910 Pomalidomide Thumb 57.3%
20 Approved;
Investigational		 SmallMoleculeDrug DB00482 Celecoxib Thumb 54.2%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.