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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: O43570
No. Gene UniProt ID Protein Name Pathway PDB
1 CA12 O43570 Carbonic anhydrase 12 hsa00910 1JCZ; 1JD0; 4HT2; 4KP5; 4KP8; 4Q0L; 4QJ0; 4QJO; 4QJW; 4WW8

5 known interactions (drugs) of input target (CA12): Carbonic anhydrase 12
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB00562 Benzthiazide Thumb
2 Approved;
Vet approved
SmallMoleculeDrug DB00819 Acetazolamide Thumb
3 Approved;
SmallMoleculeDrug DB00909 Zonisamide Thumb
4 Approved;
SmallMoleculeDrug DB00774 Hydroflumethiazide Thumb
5 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb

20 predicted interactions (drugs) of input target (CA12): Carbonic anhydrase 12
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB09460 Sodium carbonate Thumb 52.1%
2 Approved SmallMoleculeDrug DB01194 Brinzolamide Thumb 51.8%
3 Approved;
SmallMoleculeDrug DB01144 Diclofenamide Thumb 49.7%
4 Withdrawn SmallMoleculeDrug DB00311 Ethoxzolamide Thumb 46.9%
5 Approved;
Vet approved
SmallMoleculeDrug DB01021 Trichlormethiazide Thumb 41.7%
6 Approved SmallMoleculeDrug DB00606 Cyclothiazide Thumb 41.5%
7 Approved SmallMoleculeDrug DB00232 Methyclothiazide Thumb 41.0%
8 Approved SmallMoleculeDrug DB00703 Methazolamide Thumb 41.0%
9 Approved SmallMoleculeDrug DB00436 Bendroflumethiazide Thumb 38.4%
10 Approved SmallMoleculeDrug DB00869 Dorzolamide Thumb 35.8%
11 Approved SmallMoleculeDrug DB00273 Topiramate Thumb 34.3%
12 Approved SmallMoleculeDrug DB01325 Quinethazone Thumb 33.1%
13 Approved SmallMoleculeDrug DB01119 Diazoxide Thumb 31.5%
14 Approved;
Vet approved
SmallMoleculeDrug DB00999 Hydrochlorothiazide Thumb 29.1%
15 Approved;
Vet approved
SmallMoleculeDrug DB00880 Chlorothiazide Thumb 28.8%
16 Approved;
SmallMoleculeDrug DB01031 Ethinamate Thumb 27.7%
17 Experimental SmallMoleculeDrug DB08157 ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE Thumb 27.6%
18 Investigational SmallMoleculeDrug DB05304 WX-G250 Thumb 27.6%
19 Experimental SmallMoleculeDrug DB03385 4-Methylimidazole Thumb 27.5%
20 Approved;
Vet approved
SmallMoleculeDrug DB09472 Sodium sulfate Thumb 26.8%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.