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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

13 known interactions (drugs) of input target (NFKB1): Nuclear factor NF-kappa-B p105 subunit
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
SmallMoleculeDrug DB01411 Pranlukast Thumb
2 Approved;
Vet approved
SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb
3 Experimental;
SmallMoleculeDrug DB14059 SC-236 Thumb
4 Approved;
SmallMoleculeDrug DB08814 Triflusal Thumb
5 Investigational SmallMoleculeDrug DB05451 P54 Thumb
6 Approved;
SmallMoleculeDrug DB13751 Glycyrrhizic acid Thumb
7 Investigational SmallMoleculeDrug DB05487 Custirsen Thumb
8 Approved;
SmallMoleculeDrug DB01041 Thalidomide Thumb
9 Investigational SmallMoleculeDrug DB05212 HE3286 Thumb
10 Approved;
SmallMoleculeDrug DB13961 Fish oil Thumb
11 Investigational SmallMoleculeDrug DB05464 NOX-700 Thumb
12 Investigational BiotechDrug DB05471 SGN-30 Thumb
13 Investigational SmallMoleculeDrug DB05767 Andrographolide Thumb

20 predicted interactions (drugs) of input target (NFKB1): Nuclear factor NF-kappa-B p105 subunit
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB01296 Glucosamine Thumb 54.1%
2 Experimental SmallMoleculeDrug DB04464 N-Formylmethionine Thumb 30.9%
3 Approved;
SmallMoleculeDrug DB00143 Glutathione Thumb 30.8%
4 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 27.6%
5 Approved SmallMoleculeDrug DB00244 Mesalazine Thumb 25.7%
6 Approved SmallMoleculeDrug DB01050 Ibuprofen Thumb 24.5%
7 Approved SmallMoleculeDrug DB08910 Pomalidomide Thumb 24.4%
8 Approved SmallMoleculeDrug DB00316 Acetaminophen Thumb 22.9%
9 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 22.3%
10 Approved SmallMoleculeDrug DB00502 Haloperidol Thumb 21.9%
11 Approved;
SmallMoleculeDrug DB02701 Nicotinamide Thumb 21.9%
12 Experimental SmallMoleculeDrug DB07984 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1S)-1-(hydroxymethyl)propyl]acetamide Thumb 21.7%
13 Approved;
SmallMoleculeDrug DB09213 Dexibuprofen Thumb 21.6%
14 Experimental SmallMoleculeDrug DB04557 Arachidonic Acid Thumb 20.8%
15 Approved;
SmallMoleculeDrug DB01014 Balsalazide Thumb 20.0%
16 Experimental SmallMoleculeDrug DB03434 3[N-Morpholino]Propane Sulfonic Acid Thumb 19.9%
17 Approved SmallMoleculeDrug DB00469 Tenoxicam Thumb 19.9%
18 Investigational SmallMoleculeDrug DB05869 Ethyl pyruvate Thumb 19.8%
19 Approved;
SmallMoleculeDrug DB13346 Bufexamac Thumb 19.7%
20 Approved;
SmallMoleculeDrug DB13746 Bioallethrin Thumb 19.7%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.