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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q16790
No. Gene UniProt ID Protein Name Pathway PDB
1 CA9 Q16790 Carbonic anhydrase 9 hsa00910 2HKF; 3IAI; 5FL4; 5FL5; 5FL6

6 known interactions (drugs) of input target (CA9): Carbonic anhydrase 9
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
SmallMoleculeDrug DB00909 Zonisamide Thumb
2 Approved SmallMoleculeDrug DB09460 Sodium carbonate Thumb
3 Approved SmallMoleculeDrug DB00562 Benzthiazide Thumb
4 Approved;
SmallMoleculeDrug DB00774 Hydroflumethiazide Thumb
5 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb
6 Investigational SmallMoleculeDrug DB05304 WX-G250 Thumb

20 predicted interactions (drugs) of input target (CA9): Carbonic anhydrase 9
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
Vet approved
SmallMoleculeDrug DB00819 Acetazolamide Thumb 54.4%
2 Approved SmallMoleculeDrug DB01194 Brinzolamide Thumb 44.9%
3 Approved;
SmallMoleculeDrug DB01144 Diclofenamide Thumb 44.3%
4 Approved SmallMoleculeDrug DB00606 Cyclothiazide Thumb 41.9%
5 Withdrawn SmallMoleculeDrug DB00311 Ethoxzolamide Thumb 41.7%
6 Approved SmallMoleculeDrug DB00436 Bendroflumethiazide Thumb 40.5%
7 Approved;
Vet approved
SmallMoleculeDrug DB01021 Trichlormethiazide Thumb 39.3%
8 Approved SmallMoleculeDrug DB00703 Methazolamide Thumb 37.5%
9 Approved SmallMoleculeDrug DB00273 Topiramate Thumb 36.3%
10 Approved SmallMoleculeDrug DB00232 Methyclothiazide Thumb 36.1%
11 Approved SmallMoleculeDrug DB01119 Diazoxide Thumb 36.0%
12 Approved SmallMoleculeDrug DB00869 Dorzolamide Thumb 36.0%
13 Approved;
Vet approved
SmallMoleculeDrug DB00880 Chlorothiazide Thumb 32.2%
14 Approved;
Vet approved
SmallMoleculeDrug DB00999 Hydrochlorothiazide Thumb 30.4%
15 Approved;
SmallMoleculeDrug DB01031 Ethinamate Thumb 28.5%
16 Approved SmallMoleculeDrug DB01325 Quinethazone Thumb 28.0%
17 Experimental SmallMoleculeDrug DB08156 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID Thumb 27.8%
18 Approved;
Vet approved
SmallMoleculeDrug DB09472 Sodium sulfate Thumb 26.5%
19 Approved;
Vet approved
SmallMoleculeDrug DB00423 Methocarbamol Thumb 26.1%
20 Experimental SmallMoleculeDrug DB08155 N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE Thumb 25.7%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.