QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q12791
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNMA1 Q12791 Calcium-activated potassium channel subunit alpha-1 hsa04022; hsa04270; hsa04911; hsa04924; hsa04970; hsa04972 2K44; 3MT5; 3NAF


11 known interactions (drugs) of input target (KCNMA1): Calcium-activated potassium channel subunit alpha-1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00721 Procaine Thumb
2 Approved SmallMoleculeDrug DB01003 Cromoglicic acid Thumb
3 Approved SmallMoleculeDrug DB00356 Chlorzoxazone Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB04209 Dequalinium Thumb
5 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB00774 Hydroflumethiazide Thumb
7 Approved SmallMoleculeDrug DB00436 Bendroflumethiazide Thumb
8 Approved;
Vet approved		 SmallMoleculeDrug DB00999 Hydrochlorothiazide Thumb
9 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb
10 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01110 Miconazole Thumb
11 Approved SmallMoleculeDrug DB01119 Diazoxide Thumb


20 predicted interactions (drugs) of input target (KCNMA1): Calcium-activated potassium channel subunit alpha-1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 47.1%
2 Approved;
Vet approved		 SmallMoleculeDrug DB01021 Trichlormethiazide Thumb 46.7%
3 Approved SmallMoleculeDrug DB00273 Topiramate Thumb 43.1%
4 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00228 Enflurane Thumb 40.3%
5 Approved SmallMoleculeDrug DB00232 Methyclothiazide Thumb 37.8%
6 Approved SmallMoleculeDrug DB00562 Benzthiazide Thumb 37.8%
7 Approved;
Vet approved		 SmallMoleculeDrug DB00572 Atropine Thumb 35.8%
8 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb 33.5%
9 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01028 Methoxyflurane Thumb 33.4%
10 Approved;
Investigational		 SmallMoleculeDrug DB00193 Tramadol Thumb 33.0%
11 Approved SmallMoleculeDrug DB01325 Quinethazone Thumb 31.5%
12 Approved;
Investigational		 SmallMoleculeDrug DB00659 Acamprosate Thumb 31.3%
13 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 30.8%
14 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00312 Pentobarbital Thumb 30.7%
15 Approved;
Vet approved		 SmallMoleculeDrug DB00880 Chlorothiazide Thumb 30.6%
16 Withdrawn SmallMoleculeDrug DB00463 Metharbital Thumb 30.5%
17 Experimental;
Illicit		 SmallMoleculeDrug DB01549 Rolicyclidine Thumb 29.9%
18 Approved SmallMoleculeDrug DB00915 Amantadine Thumb 29.5%
19 Withdrawn SmallMoleculeDrug DB00311 Ethoxzolamide Thumb 29.0%
20 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb 28.6%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.