QuartataWeb 1.0

73 known interactions (drugs) of input target (PPARG): Peroxisome proliferator-activated receptor gamma

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter
1	Investigational	SmallMoleculeDrug	DB08915	Aleglitazar	CO[C@@H](CC1=CC=C(OCCC2=C(C)OC(=N2)C2=CC=CC=C2)C2=C1SC=C2)C(O)=O
2	Investigational	SmallMoleculeDrug	DB06521	Ertiprotafib	CC1=C(C)C2=C(C3=CC(C)=C(O[C@H](CC4=CC=CC=C4)C(O)=O)C(C)=C3)C3=CC=CC=C3C(Br)=C2S1
3	Approved	SmallMoleculeDrug	DB01039	Fenofibrate	CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C1=CC=C(Cl)C=C1
4	Approved	SmallMoleculeDrug	DB00795	Sulfasalazine	OC(=O)C1=CC(=CC=C1O)\N=N\C1=CC=C(C=C1)S(=O)(=O)NC1=NC=CC=C1
5	Experimental	SmallMoleculeDrug	DB06908	(2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID	[H][C@@](CC1=CC2=C(C=C1)N(CC1=C(C)OC(=N1)C1=C(Cl)C=CC=C1)C=C2)(OCC)C(O)=O
6	Experimental	SmallMoleculeDrug	DB07723	3-(5-methoxy-1H-indol-3-yl)propanoic acid	COC1=CC=C2NC=C(CCC(O)=O)C2=C1
7	Experimental	SmallMoleculeDrug	DB07675	(2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID	[H][C@@](CC1=CC=C(OCCN2C3=C(OC4=C2C=CC=C4)C=CC=C3)C=C1)(OCC)C(O)=O
8	Experimental	SmallMoleculeDrug	DB07053	2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID	CCCC1=C2ON=C(C2=CC=C1OCCCOC1=CC2=C(C=C1)N(CC(O)=O)C=C2)C(F)(F)F
9	Investigational	SmallMoleculeDrug	DB04971	Reglixane	NA
10	Approved; Investigational	SmallMoleculeDrug	DB01067	Glipizide	CC1=CN=C(C=N1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1
11	Investigational	SmallMoleculeDrug	DB06510	Muraglitazar	COC1=CC=C(OC(=O)N(CC(O)=O)CC2=CC=C(OCCC3=C(C)OC(=N3)C3=CC=CC=C3)C=C2)C=C1
12	Approved; Investigational; Vet approved	SmallMoleculeDrug	DB04224	Oleic Acid	CCCCCCCC\C=C\CCCCCCCC(O)=O
13	Approved; Investigational	SmallMoleculeDrug	DB00966	Telmisartan	CCCC1=NC2=C(C=C(C=C2C)C2=NC3=CC=CC=C3N2C)N1CC1=CC=C(C=C1)C1=CC=CC=C1C(O)=O
14	Approved; Nutraceutical	SmallMoleculeDrug	DB13961	Fish oil	NA
15	Approved; Investigational	SmallMoleculeDrug	DB00412	Rosiglitazone	CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C1=CC=CC=N1
16	Approved; Investigational	SmallMoleculeDrug	DB09198	Lobeglitazone	COC1=CC=C(OC2=NC=NC(=C2)N(C)CCOC2=CC=C(CC3SC(=O)NC3=O)C=C2)C=C1
17	Approved; Investigational	SmallMoleculeDrug	DB08604	Triclosan	OC1=CC(Cl)=CC=C1OC1=C(Cl)C=C(Cl)C=C1
18	Experimental	SmallMoleculeDrug	DB02746	Phthalic Acid	OC(=O)C1=CC=CC=C1C(O)=O
19	Investigational	SmallMoleculeDrug	DB06533	Ragaglitazar	CCO[C@H](CC1=CC=C(OCCN2C3=CC=CC=C3OC3=C2C=CC=C3)C=C1)C(O)=O
20	Approved; Investigational	SmallMoleculeDrug	DB00328	Indomethacin	COC1=CC2=C(C=C1)N(C(=O)C1=CC=C(Cl)C=C1)C(C)=C2CC(O)=O
21	Experimental	SmallMoleculeDrug	DB08402	2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID	OC(=O)C1=C(NC(=O)C2=C(Cl)C=C(Cl)C=C2)C=CC(OC2=NC=CC=N2)=C1
22	Approved; Investigational	SmallMoleculeDrug	DB09213	Dexibuprofen	[H][C@@](C)(C(O)=O)C1=CC=C(CC(C)C)C=C1
23	Experimental	SmallMoleculeDrug	DB08302	3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid	CCC\C(=C\C1=CC=C(O1)C1=CC(=CC=C1)C(O)=O)[N+]([O-])=O
24	Approved	SmallMoleculeDrug	DB13873	Fenofibric acid	CC(C)(OC1=CC=C(C=C1)C(=O)C1=CC=C(Cl)C=C1)C(O)=O
25	Experimental; Investigational	BiotechDrug	DB14009	Medical Cannabis	NA
26	Approved	SmallMoleculeDrug	DB00573	Fenoprofen	CC(C(O)=O)C1=CC(OC2=CC=CC=C2)=CC=C1
27	Experimental	SmallMoleculeDrug	DB04689	2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID	CCCC1=C(OCCCOC2=CC3=C(C=C2)N(CC(O)=O)C=C3)C=CC2=C1C=CC(=C2)C(=O)C1=CC=CC=C1
28	Approved; Investigational	SmallMoleculeDrug	DB01014	Balsalazide	OC(=O)CCNC(=O)C1=CC=C(C=C1)\N=N\C1=CC=C(O)C(=C1)C(O)=O
29	Experimental	SmallMoleculeDrug	DB02266	Flufenamic Acid	OC(=O)C1=CC=CC=C1NC1=CC(=CC=C1)C(F)(F)F
30	Experimental	SmallMoleculeDrug	DB14034	Darglitazone	CC1=C(CCC(=O)C2=CC=C(CC3SC(=O)NC3=O)C=C2)N=C(O1)C1=CC=CC=C1
31	Experimental	SmallMoleculeDrug	DB07863	2-chloro-5-nitro-N-phenylbenzamide	[O-][N+](=O)C1=CC=C(Cl)C(=C1)C(=O)NC1=CC=CC=C1
32	Approved; Investigational	SmallMoleculeDrug	DB01393	Bezafibrate	CC(C)(OC1=CC=C(CCNC(=O)C2=CC=C(Cl)C=C2)C=C1)C(O)=O
33	Approved; Nutraceutical	SmallMoleculeDrug	DB11133	Omega-3 fatty acids	NA
34	Experimental	SmallMoleculeDrug	DB06926	(9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid	[H][C@](O)(CCCCC)\C=C\C=C/CCCCCCCC(O)=O
35	Approved; Investigational	SmallMoleculeDrug	DB00731	Nateglinide	[H][C@](CC1=CC=CC=C1)(N=C(O)[C@@]1([H])CC[C@@]([H])(CC1)C(C)C)C(O)=O
36	Approved	SmallMoleculeDrug	DB00244	Mesalazine	NC1=CC(C(O)=O)=C(O)C=C1
37	Approved; Investigational	SmallMoleculeDrug	DB00912	Repaglinide	CCOC1=C(C=CC(CC(=O)N[C@@H](CC(C)C)C2=CC=CC=C2N2CCCCC2)=C1)C(O)=O
38	Experimental	SmallMoleculeDrug	DB03600	Capric acid	CCCCCCCCCC(O)=O
39	Approved; Investigational	SmallMoleculeDrug	DB03756	Doconexent	CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O
40	Investigational	SmallMoleculeDrug	DB05490	T131	[H][C@@]12CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC2=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N
41	Experimental	SmallMoleculeDrug	DB07172	(5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid	[H][C@@](O)(CCCC(O)=O)\C=C\C=C/C\C=C/C\C=C/C\C=C/CC
42	Approved; Nutraceutical	SmallMoleculeDrug	DB00132	Alpha-Linolenic Acid	CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O
43	Experimental	SmallMoleculeDrug	DB08121	(2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid	[H][C@@](CC1=CC=CC=C1)(OC1=CC=C(C=C1)C1=CC=CC=C1)C(O)=O
44	Approved	SmallMoleculeDrug	DB01050	Ibuprofen	CC(C)CC1=CC=C(C=C1)C(C)C(O)=O
45	Investigational; Withdrawn	SmallMoleculeDrug	DB00197	Troglitazone	CC1=C(C)C2=C(CCC(C)(COC3=CC=C(CC4SC(=O)NC4=O)C=C3)O2)C(C)=C1O
46	Experimental	SmallMoleculeDrug	DB07208	(8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid	[H][C@](O)(C\C=C/CCCCC)\C=C\CC(=O)CCCCC(O)=O
47	Approved; Nutraceutical	SmallMoleculeDrug	DB00159	Icosapent	CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
48	Investigational	SmallMoleculeDrug	DB05187	Elafibranor	CSC1=CC=C(C=C1)C(=O)\C=C\C1=CC(C)=C(OC(C)(C)C(O)=O)C(C)=C1
49	Investigational	SmallMoleculeDrug	DB12662	Naveglitazar	CO[C@@H](CC1=CC=C(OCCCOC2=CC=C(OC3=CC=CC=C3)C=C2)C=C1)C(O)=O
50	Investigational	SmallMoleculeDrug	DB06536	Tesaglitazar	CCO[C@@H](CC1=CC=C(OCCC2=CC=C(OS(C)(=O)=O)C=C2)C=C1)C(O)=O
51	Investigational	SmallMoleculeDrug	DB05854	CLX-0921	NA
52	Experimental	SmallMoleculeDrug	DB08435	(5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid	[H][C@]1(C\C=C\CCCC(O)=O)C=CC(=O)\C1=C/C=C/CCCCC
53	Approved	SmallMoleculeDrug	DB09006	Clinofibrate	CCC(C)(OC1=CC=C(C=C1)C1(CCCCC1)C1=CC=C(OC(C)(CC)C(O)=O)C=C1)C(O)=O
54	Experimental	SmallMoleculeDrug	DB07111	(4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acid	[H][C@](O)(CCC(O)=O)\C=C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC
55	Approved; Investigational	SmallMoleculeDrug	DB14011	Nabiximols	[H][C@]1(CCC(C)=C[C@@]1([H])C1=C(O)C=C(CCCCC)C=C1O)C(C)=C.[H][C@@]12CCC(C)=C[C@@]1([H])C1=C(O)C=C(CCCCC)C=C1OC2(C)C
56	Approved; Investigational	SmallMoleculeDrug	DB09061	Cannabidiol	CCCCCC1=CC(O)=C([C@@H]2C=C(C)CC[C@H]2C(C)=C)C(O)=C1
57	Experimental	SmallMoleculeDrug	DB08760	(2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid	[H][C@@](CC1=CC=CC=C1)(OC1=CC=C(Cl)C=C1)C(O)=O
58	Experimental	SmallMoleculeDrug	DB04270	(S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic Acid	[H][C@@](CC1=CC=C(OCCN2C3=C(C=CC=C3)C3=C2C=CC=C3)C=C1)(OCC)C(O)=O
59	Experimental	SmallMoleculeDrug	DB08560	3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE	FC1=CC=C(C=C1)N1N=C(C=C1NS(=O)(=O)C1=CC=CC(F)=C1)C1=CC=CS1
60	Experimental	SmallMoleculeDrug	DB07842	(2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid	[H][C@@](CC1=CC=CC=C1)(OC1=CC=C(CC)C=C1)C(O)=O
61	Experimental	SmallMoleculeDrug	DB07302	(9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid	[H][C@](O)(CCCCCCCC(O)=O)\C=C\C=C/CCCCC
62	Experimental	SmallMoleculeDrug	DB07209	(8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid	[H][C@@](O)(CC(=O)CCCCC(O)=O)\C=C/C\C=C/CCCCC
63	Approved; Investigational	SmallMoleculeDrug	DB00313	Valproic Acid	CCCC(CCC)C(O)=O
64	Approved; Investigational	SmallMoleculeDrug	DB01132	Pioglitazone	CCC1=CN=C(CCOC2=CC=C(CC3SC(=O)NC3=O)C=C2)C=C1
65	Experimental	SmallMoleculeDrug	DB07724	Indeglitazar	COC1=CC=C(C=C1)S(=O)(=O)N1C=C(CCC(O)=O)C2=CC(OC)=CC=C12
66	Approved; Investigational	SmallMoleculeDrug	DB01252	Mitiglinide	[H][C@@](CC(=O)N1C[C@@]2([H])CCCC[C@@]2([H])C1)(CC1=CC=CC=C1)C(O)=O
67	Approved; Experimental; Investigational	SmallMoleculeDrug	DB02709	Resveratrol	OC1=CC=C(\C=C\C2=CC(O)=CC(O)=C2)C=C1
68	Approved; Investigational	SmallMoleculeDrug	DB12007	Isoflavone	O=C1C(=COC2=CC=CC=C12)C1=CC=CC=C1
69	Experimental	SmallMoleculeDrug	DB07509	difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron	CCCCCCCCC1=CC=C2C=C3C=CC(CCCCC(O)=O)=[N+]3[B-](F)(F)N12
70	Approved; Investigational	SmallMoleculeDrug	DB01118	Amiodarone	CCCCC1=C(C(=O)C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)C2=C(O1)C=CC=C2
71	Investigational	SmallMoleculeDrug	DB11811	Arhalofenate	CC(=O)NCCOC(=O)[C@H](OC1=CC=CC(=C1)C(F)(F)F)C1=CC=C(Cl)C=C1
72	Experimental	SmallMoleculeDrug	DB09201	Ciglitazone	CC1(COC2=CC=C(CC3SC(=O)NC3=O)C=C2)CCCCC1
73	Approved; Investigational	SmallMoleculeDrug	DB11672	Curcumin	COC1=CC(\C=C\C(=O)CC(=O)\C=C\C2=CC(OC)=C(O)C=C2)=CC=C1O

20 predicted interactions (drugs) of input target (PPARG): Peroxisome proliferator-activated receptor gamma

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter	Confidence score
1	Investigational	SmallMoleculeDrug	DB05416	GW-501516	CC1=C(CSC2=CC(C)=C(OCC(O)=O)C=C2)SC(=N1)C1=CC=C(C=C1)C(F)(F)F	58.6%
2	Approved; Investigational; Nutraceutical	SmallMoleculeDrug	DB00143	Glutathione	N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O	56.1%
3	Approved	SmallMoleculeDrug	DB01241	Gemfibrozil	CC1=CC(OCCCC(C)(C)C(O)=O)=C(C)C=C1	51.2%
4	Approved; Investigational; Withdrawn	BiotechDrug	DB00055	Drotrecogin alfa	NA	51.0%
5	Experimental	SmallMoleculeDrug	DB01890	N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide	[H][C@@](C)(CCC(=O)N(CCCN=C(O)[C@]([H])(O)[C@@]([H])(O)[C@]([H])(O)[C@]([H])(O)CO)CCCN=C(O)[C@]([H])(O)[C@@]([H])(O)[C@]([H])(O)[C@]([H])(O)CO)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@]([H])(O)CC[C@]4(C)[C@@]3([H])C[C@]([H])(O)[C@]12C	49.8%
6	Approved; Investigational	SmallMoleculeDrug	DB09064	Ciprofibrate	CC(C)(OC1=CC=C(C=C1)C1CC1(Cl)Cl)C(O)=O	49.7%
7	Experimental	SmallMoleculeDrug	DB04557	Arachidonic Acid	CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O	48.5%
8	Approved	SmallMoleculeDrug	DB09422	Soybean oil	NA	48.4%
9	Approved; Experimental	SmallMoleculeDrug	DB03796	Palmitic Acid	CCCCCCCCCCCCCCCC(O)=O	46.7%
10	Approved; Investigational	SmallMoleculeDrug	DB00636	Clofibrate	CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1	46.6%
11	Investigational	SmallMoleculeDrug	DB05188	KD3010	NA	45.4%
12	Experimental	SmallMoleculeDrug	DB07215	2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID	CC1=C(SC(=N1)C1=CC=C(C=C1)C(F)(F)F)C(=O)NCC1=CC=C(OC(C)(C)C(O)=O)C=C1	45.2%
13	Approved	SmallMoleculeDrug	DB11605	Myrrh	NA	44.5%
14	Approved; Investigational; Nutraceutical	SmallMoleculeDrug	DB01708	Prasterone	[H][C@@]12CCC(=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@]([H])(O)CC[C@]12C	44.0%
15	Approved; Experimental; Investigational	SmallMoleculeDrug	DB04519	Caprylic acid	CCCCCCCC(O)=O	43.6%
16	Approved; Investigational; Withdrawn	BiotechDrug	DB00013	Urokinase	NA	42.9%
17	Approved; Investigational	SmallMoleculeDrug	DB00605	Sulindac	CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(C=C1)S(C)=O	41.5%
18	Experimental	SmallMoleculeDrug	DB03435	Uridine-5'-Diphosphate	O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O	40.9%
19	Experimental	SmallMoleculeDrug	DB07070	(2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid	[H][C@](CC)(CC1=CC(CNC(=O)C2=C(F)C=C(C=C2)C(F)(F)F)=C(OC)C=C1)C(O)=O	39.1%
20	Approved; Investigational; Vet approved	SmallMoleculeDrug	DB00749	Etodolac	CCC1=C2NC3=C(CCOC3(CC)CC(O)=O)C2=CC=C1	39.1%