QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P07204
No. Gene UniProt ID Protein Name Pathway PDB
1 THBD P07204 Thrombomodulin hsa04610; hsa04933; hsa05418 1ADX; 1DQB; 1DX5; 1EGT; 1FGD; 1FGE; 1HLT; 1TMR; 1ZAQ; 2ADX; 3GIS


3 known interactions (drugs) of input target (THBD): Thrombomodulin
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB09213 Dexibuprofen Thumb
2 Approved SmallMoleculeDrug DB01050 Ibuprofen Thumb
3 Approved;
Investigational;
Withdrawn		 BiotechDrug DB00055 Drotrecogin alfa Thumb


20 predicted interactions (drugs) of input target (THBD): Thrombomodulin
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00795 Sulfasalazine Thumb 31.2%
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb 31.1%
3 Investigational;
Withdrawn		 SmallMoleculeDrug DB00197 Troglitazone Thumb 24.6%
4 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb 23.7%
5 Approved;
Investigational;
Withdrawn		 BiotechDrug DB00013 Urokinase Thumb 22.0%
6 Approved;
Nutraceutical		 SmallMoleculeDrug DB01373 Calcium Thumb 21.3%
7 Approved;
Investigational		 BiotechDrug DB13151 Anti-inhibitor coagulant complex Thumb 21.0%
8 Approved;
Investigational		 BiotechDrug DB00100 Coagulation Factor IX (Recombinant) Thumb 20.4%
9 Experimental;
Investigational		 SmallMoleculeDrug DB02587 Colforsin Thumb 20.3%
10 Experimental SmallMoleculeDrug DB04557 Arachidonic Acid Thumb 20.1%
11 Approved SmallMoleculeDrug DB00244 Mesalazine Thumb 20.0%
12 Investigational SmallMoleculeDrug DB06266 Lonidamine Thumb 19.8%
13 Approved;
Vet approved		 SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 19.5%
14 Approved;
Investigational		 SmallMoleculeDrug DB01088 Iloprost Thumb 19.5%
15 Approved SmallMoleculeDrug DB08820 Ivacaftor Thumb 19.0%
16 Approved SmallMoleculeDrug DB04552 Niflumic Acid Thumb 18.7%
17 Approved;
Investigational		 SmallMoleculeDrug DB00328 Indomethacin Thumb 18.5%
18 Experimental SmallMoleculeDrug DB02266 Flufenamic Acid Thumb 18.3%
19 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB04224 Oleic Acid Thumb 18.2%
20 Approved SmallMoleculeDrug DB04941 Crofelemer Thumb 17.8%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.