QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q5NUL3
No. Gene UniProt ID Protein Name Pathway PDB
1 FFAR4 Q5NUL3 Free fatty acid receptor 4 NA NA


3 known interactions (drugs) of input target (FFAR4): Free fatty acid receptor 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB05532 BMS-488043 Thumb
2 Investigational BiotechDrug DB05793 PRO-542 Thumb
3 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb


20 predicted interactions (drugs) of input target (FFAR4): Free fatty acid receptor 4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00393 Nimodipine Thumb 24.4%
2 Approved;
Investigational		 SmallMoleculeDrug DB09236 Lacidipine Thumb 24.3%
3 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00141 N-Acetylglucosamine Thumb 23.8%
4 Approved;
Investigational		 SmallMoleculeDrug DB09232 Cilnidipine Thumb 22.3%
5 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 22.2%
6 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb 22.1%
7 Investigational;
Withdrawn		 SmallMoleculeDrug DB00197 Troglitazone Thumb 21.6%
8 Approved;
Experimental		 SmallMoleculeDrug DB13746 Bioallethrin Thumb 20.2%
9 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 20.0%
10 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 19.7%
11 Approved SmallMoleculeDrug DB00381 Amlodipine Thumb 18.8%
12 Approved;
Investigational		 SmallMoleculeDrug DB01017 Minocycline Thumb 18.7%
13 Investigational;
Withdrawn		 SmallMoleculeDrug DB01388 Mibefradil Thumb 18.3%
14 Approved;
Investigational		 SmallMoleculeDrug DB09230 Azelnidipine Thumb 18.1%
15 Approved;
Investigational		 SmallMoleculeDrug DB00328 Indomethacin Thumb 18.1%
16 Approved;
Investigational		 SmallMoleculeDrug DB03756 Doconexent Thumb 18.1%
17 Approved;
Investigational		 SmallMoleculeDrug DB11633 Isavuconazole Thumb 17.8%
18 Approved;
Investigational		 SmallMoleculeDrug DB04540 Cholesterol Thumb 17.7%
19 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb 17.4%
20 Approved;
Investigational		 SmallMoleculeDrug DB06712 Nilvadipine Thumb 17.3%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.