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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q09428
No. Gene UniProt ID Protein Name Pathway PDB
1 ABCC8 Q09428 ATP-binding cassette sub-family C member 8 hsa02010; hsa04911; hsa04930 NA


13 known interactions (drugs) of input target (ABCC8): ATP-binding cassette sub-family C member 8
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB01252 Mitiglinide Thumb
2 Approved SmallMoleculeDrug DB01120 Gliclazide Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB00672 Chlorpropamide Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB01067 Glipizide Thumb
5 Approved SmallMoleculeDrug DB00222 Glimepiride Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB01251 Gliquidone Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB00839 Tolazamide Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB00912 Repaglinide Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB01382 Glycodiazine Thumb
10 Approved SmallMoleculeDrug DB01016 Glyburide Thumb
11 Approved;
Investigational		 SmallMoleculeDrug DB00731 Nateglinide Thumb
12 Approved;
Investigational		 SmallMoleculeDrug DB01124 Tolbutamide Thumb
13 Investigational;
Nutraceutical		 SmallMoleculeDrug DB00171 ATP Thumb


20 predicted interactions (drugs) of input target (ABCC8): ATP-binding cassette sub-family C member 8
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00217 Bethanidine Thumb 28.8%
2 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00414 Acetohexamide Thumb 28.8%
3 Approved;
Investigational		 SmallMoleculeDrug DB00922 Levosimendan Thumb 28.6%
4 Experimental;
Investigational		 SmallMoleculeDrug DB08838 Agmatine Thumb 27.4%
5 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 26.5%
6 Approved;
Nutraceutical		 SmallMoleculeDrug DB00138 Cystine Thumb 25.7%
7 Approved;
Investigational		 SmallMoleculeDrug DB09213 Dexibuprofen Thumb 25.5%
8 Approved SmallMoleculeDrug DB01119 Diazoxide Thumb 24.2%
9 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB01942 Formic Acid Thumb 24.0%
10 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00167 L-Isoleucine Thumb 23.3%
11 Approved;
Investigational		 BiotechDrug DB00030 Insulin Human Thumb 23.1%
12 Approved;
Investigational		 SmallMoleculeDrug DB00747 Scopolamine Thumb 22.9%
13 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb 22.4%
14 Approved SmallMoleculeDrug DB09063 Ceritinib Thumb 22.0%
15 Approved;
Investigational		 SmallMoleculeDrug DB12007 Isoflavone Thumb 21.9%
16 Investigational SmallMoleculeDrug DB06521 Ertiprotafib Thumb 21.6%
17 Approved;
Nutraceutical		 SmallMoleculeDrug DB00142 Glutamic Acid Thumb 21.3%
18 Experimental SmallMoleculeDrug DB08121 (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid Thumb 21.2%
19 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01392 Yohimbine Thumb 21.1%
20 Approved;
Investigational		 SmallMoleculeDrug DB01169 Arsenic trioxide Thumb 21.1%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.